ChemicalBook > CAS DataBase List > H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH

H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH

Product Name
H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH
CAS No.
136461-80-8
Chemical Name
H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH
Synonyms
Osteocalcin(1-49);BGP (1-49) (HUMAN);BONE GLA PROTEIN (HUMAN);OSTEOCALCIN (1-49) (HUMAN);BONE GLA PROTEIN (1-49) (HUMAN);GLA17,21,24-OSTEOCALCIN (HUMAN);[GLA17,21,24]-OSTEOCALCIN (1-49);OSTEOCALCIN (HUMAN, GLA17,21,24);Osteocalcin fragment 1-49 Human >=94% (HPLC), solid;YLYQWLGAPVPYPDPL-GLA-PRR-GLA-VC-GLA-LNPDCDELADHIGFQEAYRRFYGPV
CBNumber
CB4370884
Molecular Formula
C269H381N67O82S2
Formula Weight
5929.43
MOL File
136461-80-8.mol
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H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH Property

storage temp. 
-20°C
solubility 
Formic Acid: 1 mg/ml
form 
solid
Sequence
Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-{Gla}- Pro-Arg-Arg-{Gla}-Val-Cys-{Gla}-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val (Disulfide bridge:Cys23-Cys29)
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Safety

WGK Germany 
3
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
O5761
Product name
Osteocalcin fragment 1-49 Human
Purity
≥94%(HPLC),solid
Packaging
500μg
Price
$878
Updated
2025/07/31
Sigma-Aldrich
Product number
O5761
Product name
Osteocalcin fragment 1-49 Human
Purity
≥94% (HPLC), solid
Packaging
1mg
Price
$1690
Updated
2025/07/31
Cayman Chemical
Product number
24723
Product name
Osteocalcin (1-49) (human) (trifluoroacetate salt)
Purity
≥95%
Packaging
100μg
Price
$459
Updated
2024/03/01
Cayman Chemical
Product number
24723
Product name
Osteocalcin (1-49) (human) (trifluoroacetate salt)
Purity
≥95%
Packaging
500μg
Price
$1148
Updated
2024/03/01
Biorbyt Ltd
Product number
orb372957
Product name
Osteocalcin (1-49)
Purity
> 95%
Packaging
1mg
Price
$1412.7
Updated
2021/12/16
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H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH Chemical Properties,Usage,Production

Description

Osteocalcin (1-49) is a non-collagenous peptide that is secreted by osteoblasts and odontoblasts and comprises 1-2% of the total protein in bone. Secretion of osteocalcin (1-49) is stimulated by 1,25-dihydroxy vitamin D and plasma levels increase in diseases that induce dysregulated bone turnover such as osteoporosis, Paget''s disease, and primary hyperparathyroidism. Osteocalcin (1-49) is positively correlated with insulin sensitivity and negatively correlated with high blood glucose levels in women. In vitro, osteocalcin induces chemotaxis of MDA-MB-231 breast cancer cells, human peripheral blood monocytes, and rat osteosarcoma cells with osteoblast-like characteristics. It is also expressed by vascular smooth muscle cells (VSMCs) displaying an osteoblast-like phenotype and has been positively associated with calcification of aortic tissue and heart valves in humans.

Uses

Osteocalcin (human) is a vitamin K-dependent bone specific protein. Osteocalcin (human) is chemotactic for several of the cell types frequently found at bone remodeling surfaces[1][2].

References

[1] Kuronen I, et al. Production of monoclonal and polyclonal antibodies against human osteocalcin sequences and development of a two-site ELISA for intact human osteocalcin. J Immunol Methods. 1993 Aug 9;163(2):233-40. DOI:10.1016/0022-1759(93)90127-s
[2] Mundy GR, et al. Chemotactic activity of the gamma-carboxyglutamic acid containing protein in bone. Calcif Tissue Int. 1983;35(2):164-8. DOI:10.1007/BF02405025
[3] Colford JW, et al. Immunoradiometric assay for intact human osteocalcin(1-49) without cross-reactivity to breakdown products. Clin Chem. 1999 Apr;45(4):526-31. PMID:10102913

H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH Suppliers

China 71 Japan 1 Switzerland 1 United States 10 Global 83
GL Biochem (Shanghai) Ltd
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136461-80-8, H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OHRelated Search:

GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLU-PRO-ARG H-PHE-TYR-GLY-PRO-VAL-OH H-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH Osteocalcin (1-43) Osteocalcin 30-43 Fragment Osteoblast Activating Peptide (mouse, rat) SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE METHYL ISOCYANOACETATE Tris(2,4-pentanedionato)chroMiuM(III) Ethyl isocyanoacetate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) N-BUTYLISOCYANIDE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tosylmethyl isocyanide PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Benzyl isocyanide

  • OSTEOCALCIN (HUMAN, GLA17,21,24)
  • OSTEOCALCIN (1-49) (HUMAN)
  • TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL
  • YLYQWLGAPVPYPDPL-GLA-PRR-GLA-VC-GLA-LNPDCDELADHIGFQEAYRRFYGPV
  • H-TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL-OH
  • [GLA17,21,24]-OSTEOCALCIN (1-49)
  • GLA17,21,24-OSTEOCALCIN (HUMAN)
  • BONE GLA PROTEIN (HUMAN)
  • BONE GLA PROTEIN (1-49) (HUMAN)
  • BGP (1-49) (HUMAN)
  • TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL (DISULFIDE BRIDGE: CYS23-CYS29)
  • TYR-LEU-TYR-GLN-TRP-LEU-GLY-ALA-PRO-VAL-PRO-TYR-PRO-ASP-PRO-LEU-GLA-PRO-ARG-ARG-GLA-VAL-CYS-GLA-LEU-ASN-PRO-ASP-CYS-ASP-GLU-LEU-ALA-ASP-HIS-ILE-GLY-PHE-GLN-GLU-ALA-TYR-ARG-ARG-PHE-TYR-GLY-PRO-VAL: YLYQWLGAPVPYPDPL-GLA-PRR-GLA-VC-GLA-LNPDCDELADHIGFQEAYRRFY
  • YLYQWLGAPVPYPDPL-Gla-PRR-Gla-VC-Gla-LNPDCDELADHIGFQEAYRRFYGPV(Gla=γ-CarboxyglutamicAcid:Disulfidebridge:23-29)
  • Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val(Disu
  • Osteocalcin(1-49)
  • Osteocalcin fragment 1-49 Human >=94% (HPLC), solid
  • 136461-80-8
  • C269H381N67O82S2
  • Intracellular Calcium Signaling
  • BioChemical
  • Calcium-associated Proteins
  • Cell Biology
  • Cell Signaling and Neuroscience
  • peptide
  • Calcium Associated Protein FragmentsPeptides and Proteins
  • Calcium-associated Proteins
  • Proteins for Cell Biology
  • Ion Channel Modulating Peptides
  • Peptides for Cell Biology