2,5-Dichloropyrazine
Application- Product Name
- 2,5-Dichloropyrazine
- CAS No.
- 19745-07-4
- Chemical Name
- 2,5-Dichloropyrazine
- Synonyms
- NSC 349788;2,5-DICHLOROPYRAZINE;Pyrazine, 2,5-dichloro-;2,5-Dichloro-1,4-diazine;2,5-Dichloropyrazine ISO 9001：2015 REACH
- CBNumber
- CB4380847
- Molecular Formula
- C4H2Cl2N2
- Formula Weight
- 148.98
- MOL File
- 19745-07-4.mol
2,5-Dichloropyrazine Property
- Melting point:
- 0 °C (approx)
- Boiling point:
- 184.4±35.0 °C(Predicted)
- Density
- 1.493±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- liquid
- pka
- -4.23±0.10(Predicted)
- color
- Colourless
- InChI
- InChI=1S/C4H2Cl2N2/c5-3-1-7-4(6)2-8-3/h1-2H
- InChIKey
- JVSDZAGCHKCSGR-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(Cl)N=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B419163
- Product name
- 2,5-Dichloropyrazine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W4185
- Product name
- 2,5-Dichloropyrazine
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- FD139859
- Product name
- 2,5-Dichloropyrazine
- Packaging
- 2g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- D11395
- Product name
- 2,5-Dichloropyrazine
- Purity
- 95%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 069847
- Product name
- 2,5-Dichloropyrazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
2,5-Dichloropyrazine Chemical Properties,Usage,Production
Application
2,5-Dichloropyrazine is a pharmaceutical intermediate that can be obtained by first chlorinating pyrazin-2-amine to obtain 5-chloropyrazin-2-amine, and then by diazotization to obtain 2,5-dichloropyrazine.
Chemical Properties
Colorless liquid
Synthesis
33332-29-5
19745-07-4
Step 2: Synthesis of 2,5-dichloropyrazine To a stirred solution of 5-chloropyrazin-2-amine (1 g, 7.751 mmol) in concentrated hydrochloric acid (10 mL), an aqueous solution of sodium nitrite (1.1 g, 15.89 mmol) was slowly added at -10 °C, and the addition process lasted for 1 hour. After addition, the reaction mixture was stirred at 0 °C for 1 h, and then brought to room temperature and continued stirring for 2 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was neutralized with 50% sodium hydroxide (NaOH) solution and subsequently extracted with dichloromethane (DCM). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography on silica gel (100-200 mesh) to afford 2,5-dichloropyrazine (0.59 g, 15% yield) as a colorless oil using hexane solution containing 2% ethyl acetate as eluent. Mass spectrum (MS): 184.1 [M-1].
References
[1] Patent: US2017/291910, 2017, A1. Location in patent: Paragraph 0565-0567
[2] Patent: WO2008/85316, 2008, A1. Location in patent: Page/Page column 53-54
[3] Patent: WO2005/97778, 2005, A1. Location in patent: Page/Page column 15
[4] Patent: WO2004/56369, 2004, A1. Location in patent: Page/Page column 24
[5] Patent: WO2005/123723, 2005, A1. Location in patent: Page/Page column 11-12
2,5-Dichloropyrazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Dichloropyrazine manufacturers
- Product
- 2,5-Dichloropyrazine 19745-07-4
- Price
- US $12.99/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-24
- Product
- 2,5-dichloropyrazine 19745-07-4
- Price
- US $12.99/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-24
- Product
- 2,5-Dichloropyrazine 19745-07-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 800 tons
- Release date
- 2020-04-28