ChemicalBook > CAS DataBase List > 1-Boc-2-Methylpiperazine

1-Boc-2-Methylpiperazine

Product Name
1-Boc-2-Methylpiperazine
CAS No.
120737-78-2
Chemical Name
1-Boc-2-Methylpiperazine
Synonyms
1-Boc-2-Methylpiperazine;N-Boc-2-methylpiperazine;1-N-BOC-2-METHYLPIPERAZINE;N-4-BOC-3-METHYLPIPERIZINE;N-1-BOC-2-METHYLPIPERAZINE;4-N-Boc-3-methylpiperazine;4-Boc-3-Methyl piperazine;N-4-BOC-3-METHYL-PIPERAZINE;1-N-Boc-2-methyl-piperizine;(+/-)-1-N-BOC-2-METHYL PIPERAZINE
CBNumber
CB4391948
Molecular Formula
C10H20N2O2
Formula Weight
200.28
MOL File
120737-78-2.mol
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1-Boc-2-Methylpiperazine Property

Boiling point:
268.7±15.0 °C(Predicted)
Density 
0.997±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Oil
pka
8.49±0.40(Predicted)
color 
Colourless
CAS DataBase Reference
120737-78-2(CAS DataBase Reference)
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Safety

RIDADR 
2735
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
B6870
Product name
tert-Butyl 2-Methylpiperazine-1-carboxylate
Purity
min. 98.0 %
Packaging
5G
Price
$94
Updated
2025/07/31
TCI Chemical
Product number
B6870
Product name
tert-Butyl 2-Methylpiperazine-1-carboxylate
Purity
min. 98.0 %
Packaging
25G
Price
$282
Updated
2025/07/31
TRC
Product number
B809478
Product name
tert-Butyl2-Methylpiperazine-1-carboxylate
Packaging
5mg
Price
$55
Updated
2021/12/16
Usbiological
Product number
262029
Product name
1-Boc-2-methylpiperazine
Packaging
1g
Price
$375
Updated
2021/12/16
Oakwood
Product number
037090
Product name
1-N-Boc-2-methylpiperazine
Purity
95%
Packaging
1g
Price
$10
Updated
2021/12/16
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1-Boc-2-Methylpiperazine Chemical Properties,Usage,Production

Uses

tert-Butyl 2-methylpiperazine-1-carboxylate is a useful reagent used in the synthesis of anthrafuran carboxamides with antitumor properties.

Synthesis

120737-77-1

120737-78-2

General procedure for the synthesis of tert-butyl 2-methylpiperazine-1-carboxylate from the compound (CAS: 120737-77-1): a mixture of tert-butyl (RS)-4-benzyl-2-methylpiperazine-1-carboxylate (3.41 g, 11.7 mmol), ethanol (125 mL), and Pearlman's catalyst (0.854 g, 6.08 mmol) was was hydrogenated overnight at 36 psi pressure at ambient temperature. Upon completion of the reaction, the mixture was filtered and the solids were washed sequentially with ethanol, dichloromethane (DCM) and methanol (MeOH). The filtrate and washings were combined, concentrated in vacuum, redissolved in dichloromethane, filtered again and concentrated in vacuum to give tert-butyl 2-methylpiperazine-1-carboxylate as a beige oil (2.0 g, 86% yield). The nuclear magnetic resonance (NMR) spectrum of the product was in agreement with the data reported in the literature (J. Org. Chem. 1995, 60, 4183).

References

[1] Patent: WO2007/135427, 2007, A1. Location in patent: Page/Page column 31
[2] Patent: US4880808, 1989, A

1-Boc-2-Methylpiperazine Preparation Products And Raw materials

Raw materials

1,1'-Carbonyldiimidazole Di-tert-butyl dicarbonate Trifluoroacetic acid N-Benzylethanolamine Diethyl azodicarboxylate Tetrahydrofuran Lithium Aluminum Hydride Dichloromethane Triphenylphosphine DL-Alanine

Preparation Products

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View Lastest Price from 1-Boc-2-Methylpiperazine manufacturers

Career Henan Chemical Co
Product
1-Boc-2-Methylpiperazine 120737-78-2
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-08

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