Ethyl 2-methylthiazole-5-carboxylate
- Product Name
- Ethyl 2-methylthiazole-5-carboxylate
- CAS No.
- 79836-78-5
- Chemical Name
- Ethyl 2-methylthiazole-5-carboxylate
- Synonyms
- 2-methyl-5-(carbethoxy)thiazole;ETHYL 2-METHYL-5-THIAZOLECARBOXYLATE;ETHYL 2-METHYL-THIAZOLE-5-CARBOXYLATE;5-(Ethoxycarbonyl)-2-methyl-1,3-thiazole;ETHYL2-METHYL-1,3-THIAZOLE-5-CARBOXYLATE;2-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER;5-Thiazolecarboxylicacid, 2-Methyl-, ethyl ester
- CBNumber
- CB4392369
- Molecular Formula
- C7H9NO2S
- Formula Weight
- 171.22
- MOL File
- 79836-78-5.mol
Ethyl 2-methylthiazole-5-carboxylate Property
- Boiling point:
- 117-120 °C
- Density
- 1.198±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 1.61±0.10(Predicted)
- Appearance
- Colorless to yellow Liquid
- InChIKey
- ORCQTMZHDQSNOJ-UHFFFAOYSA-N
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SYX00356
- Product name
- Ethyl 2-methylthiazole-5-carboxylate
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- E929215
- Product name
- Ethyl 2-methylthiazole-5-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 8H70-1-T9
- Product name
- Ethyl 2-methyl-1,3-thiazole-5-carboxylate
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
- Product number
- 069644
- Product name
- Ethyl 2-methylthiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $146
- Updated
- 2021/12/16
- Product number
- 069644
- Product name
- Ethyl 2-methylthiazole-5-carboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
Ethyl 2-methylthiazole-5-carboxylate Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of the American Chemical Society, 104, p. 4461, 1982 DOI: 10.1021/ja00380a022
Synthesis
62-55-5
33142-21-1
79836-78-5
To a stirred solution of ethyl 2-chloro-3-oxopropanoate (5.0 g, 33 mmol) in benzene (50 mL) under argon protection was added thioacetamide (2.5 g, 33 mmol) and the mixture was heated to reflux. After 4 h, the reaction mixture was cooled to room temperature, diluted with water (50 mL) and neutralized with saturated sodium bicarbonate solution to pH 7. Subsequently, the reaction mixture was extracted with ethyl acetate and the organic phases were combined and washed sequentially with water and brine. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated in vacuum. Purification by silica gel column chromatography (eluent: heptane/ethyl acetate, 0 to 50% gradient) afforded ethyl 2-methylthiazole-5-carboxylate (2.68 g, 47% yield) as a yellow liquid. Mass spectrometry (MS) analysis showed: m/e = 172.0 [M + H]+.
References
[1] Journal of the American Chemical Society, 1982, vol. 104, # 16, p. 4461 - 4465
[2] Patent: WO2010/127974, 2010, A1. Location in patent: Page/Page column 43
[3] Patent: WO2018/53157, 2018, A1. Location in patent: Page/Page column 108; 109
[4] Patent: WO2018/160878, 2018, A1. Location in patent: Page/Page column 278-279
[5] Journal of Chemical Research, 2011, vol. 35, # 5, p. 313 - 316
Ethyl 2-methylthiazole-5-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl 2-methylthiazole-5-carboxylate manufacturers
- Product
- Ethyl 2-methylthiazole-5-carboxylate 79836-78-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-21