ChemicalBook > CAS DataBase List > 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

Product Name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
CAS No.
1892-57-5
Chemical Name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Synonyms
EDCI;EDAC;1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;WSCI;WSCD;N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine;1-(3-Dimethylaminopropyl)-3-;N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE;({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine;WSC【Dotite】
CBNumber
CB4403030
Molecular Formula
C8H17N3
Formula Weight
155.24
MOL File
1892-57-5.mol
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Property

Boiling point:
66-68°C/1mm
Density 
0.877 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.461
Flash point:
66-68°C/1mm
storage temp. 
-20°C
solubility 
Chloroform
pka
9.52±0.28(Predicted)
form 
Liquid
Specific Gravity
0.885
color 
Colorless to slightly yellow
Water Solubility 
Soluble in water.
Sensitive 
Air Sensitive
BRN 
507429
InChIKey
LMDZBCPBFSXMTL-UHFFFAOYSA-N
CAS DataBase Reference
1892-57-5(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
EPA Substance Registry System
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2735 8/PG 3
WGK Germany 
3
1-3-10
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29252900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
39391
Product name
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide
Purity
≥97.0% (T)
Packaging
10ml
Price
$185
Updated
2024/03/01
Sigma-Aldrich
Product number
39391
Product name
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide
Purity
≥97.0% (T)
Packaging
50ml
Price
$798
Updated
2024/03/01
TCI Chemical
Product number
D4029
Product name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
D4029
Product name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$240
Updated
2024/03/01
Alfa Aesar
Product number
B25057
Product name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%
Packaging
5g
Price
$106
Updated
2024/03/01
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties,Usage,Production

Description

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].

Chemical Properties

Clear light yellow liquid

Uses

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

General Description

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

Synthesis

The production method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is to react with N, N'-dimethylpropanediamine and carbon disulfide as raw materials to prepare N, N'- Dimethylpropylthiourea. Then it is oxidized with ethyl chloroformate to obtain N, N'-dimethylpropyl isothiocyanate, which is then reacted with ethylamine and oxidized with sodium hypochlorite to obtain the product 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide.

References

[1] Manjula ;Mummadisetti et al.“Chapter Five-An approach to nearest neighbor analysis of pigment-protein complexes using chemical cross-linking in combination with mass spectrometry.” Methods in enzymology" Methods in Enzymology, 680 (2023) 139-162.
[2] Dmour, Isra and M. Taha. “Natural and semisynthetic polymers in pharmaceutical nanotechnology.”Organic Materials as Smart Nanocarriers for Drug Delivery (2018) 35-100.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Suppliers

Zhejiang pukang chemical co. LTD
Tel
13362001881 13362001881
Fax
86-570-6030880
Email
zfbulk@sina.com
Country
China
ProdList
1
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58
Shanghai Medpep Co., Ltd
Tel
021-65566949 13901795941
Fax
86-21-51861665
Email
market@medpep.com
Country
China
ProdList
176
Advantage
66
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20811
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60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7508
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18217
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66
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View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price
US $30.00-9.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-31
Hebei Mojin Biotechnology Co., Ltd
Product
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-27

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