ChemicalBook > CAS DataBase List > 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide

Product Name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
CAS No.
1892-57-5
Chemical Name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Synonyms
EDCI;EDAC;1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;WSCI;WSCD;N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine;1-(3-Dimethylaminopropyl)-3-;N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE;({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine;WSC【Dotite】
CBNumber
CB4403030
Molecular Formula
C8H17N3
Formula Weight
155.24
MOL File
1892-57-5.mol
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Property

Boiling point:
66-68°C/1mm
Density 
0.877 g/mL at 20 °C (lit.)
refractive index 
n20/D 1.461
Flash point:
66-68°C/1mm
storage temp. 
-20°C
solubility 
Chloroform
pka
9.52±0.28(Predicted)
form 
Liquid
Specific Gravity
0.885
color 
Colorless to slightly yellow
Water Solubility 
Soluble in water.
Sensitive 
Air Sensitive
BRN 
507429
InChIKey
LMDZBCPBFSXMTL-UHFFFAOYSA-N
CAS DataBase Reference
1892-57-5(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5)
EPA Substance Registry System
1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2735 8/PG 3
WGK Germany 
3
F 
1-3-10
TSCA 
Yes
HazardClass 
8
PackingGroup 
III
HS Code 
29252900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H315Causes skin irritation

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
39391
Product name
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide
Purity
≥97.0% (T)
Packaging
10ml
Price
$185
Updated
2024/03/01
Sigma-Aldrich
Product number
39391
Product name
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide
Purity
≥97.0% (T)
Packaging
50ml
Price
$798
Updated
2024/03/01
TCI Chemical
Product number
D4029
Product name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$80
Updated
2024/03/01
TCI Chemical
Product number
D4029
Product name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$240
Updated
2024/03/01
Alfa Aesar
Product number
B25057
Product name
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%
Packaging
5g
Price
$106
Updated
2024/03/01
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties,Usage,Production

Description

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].

Chemical Properties

Clear light yellow liquid

Uses

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

General Description

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

Synthesis

The production method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is to react with N, N'-dimethylpropanediamine and carbon disulfide as raw materials to prepare N, N'- Dimethylpropylthiourea. Then it is oxidized with ethyl chloroformate to obtain N, N'-dimethylpropyl isothiocyanate, which is then reacted with ethylamine and oxidized with sodium hypochlorite to obtain the product 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide.

References

[1] Manjula ;Mummadisetti et al.“Chapter Five-An approach to nearest neighbor analysis of pigment-protein complexes using chemical cross-linking in combination with mass spectrometry.” Methods in enzymology" Methods in Enzymology, 680 (2023) 139-162.
[2] Dmour, Isra and M. Taha. “Natural and semisynthetic polymers in pharmaceutical nanotechnology.”Organic Materials as Smart Nanocarriers for Drug Delivery (2018) 35-100.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials

Raw materials

Ethyl isocyanate 3-Dimethylaminopropylamine Potassium carbonate Triethylamine Tosyl chloride Diethyl ether Dichloromethane

Preparation Products

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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Suppliers

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View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-31
Hebei Weibang Biotechnology Co., Ltd
Product
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-21
Hebei Yanxi Chemical Co., Ltd.
Product
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 1892-57-5
Price
US $30.00-9.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-25

1892-57-5, 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimideRelated Search:

ISOXADIFEN-ETHYL N,N'-Diisopropylcarbodiimide 4-Dimethylaminobenzoic acid Ethylparaben Ethyl acetate Ethyl acrylate Ethanol N,N-Diisopropylethylamine Cyanamide Lithium diisopropylamide 4-Dimethylaminopyridine N,N-Dimethylallylamine Ethyl pyruvate Ethyl formate N,N-Dimethylformamide O-Phthalimide Ethyl cyanoacetate 4-Dimethylaminobenzaldehyde

  • 1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE
  • 1-(3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE
  • WATER-SOLUBLE CARBODIIMIDE
  • WSCD
  • WSCI
  • N-ETHYL-N'-(3-DIMETHYLAMINOPROPYL)CARBODIIMIDE
  • N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE
  • [3-(Dimethylamino)propyl]ethylcarbodiimide
  • ethyldimethylaminopropylcarbodiimide
  • n’-(ethylcarbonimidoyl)-n,n-dimethyl-3-propanediamine
  • N3-Ethyliminomethylene-N1,N1-dimethylpropane-1,3-diamine
  • 1-(3-dimethylaminopropyl)-N?ethylcarbodiimide
  • N'-(ethylcarbonimidoyl)-N,N-dimethylpropane-1,3-diamine
  • EDAC
  • EDCI
  • Rivaroxaban Impurity 139
  • N'-(Ethylkohlenstoffimidoyl)-N,N-dimethylpropan-1,3-diamin
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide 98%
  • EDC polymer-bound, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide polymer-bound, N-(3-Dimethylaminopropyl)-Nμ-ethylcarbodiimide polymer-bound
  • EDC, WSC, N-Ethyl-Nμ-(3-dimethylaminopropyl)carbodiimide
  • 1-ehyl-3-(dimethylaminopropyl)carbodiimide
  • 3-[(Ethylcarbonimidoyl)amino]-N,N-dimethyl-1-propanamine
  • WSC【Dotite】
  • 3-(ethyliminomethyleneamino)propyl-dimethyl-amine
  • 3-(ethyliminomethylideneamino)-N,N-dimethyl-propan-1-amine
  • 3-(ethyliminomethylideneamino)-N,N-dimethylpropan-1-amine
  • N-(3-Dimethylaminopr
  • N-(3-DiMethylaMinopropyl)-N'-ethylcarb
  • N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide(EDCI)
  • N-(3-DiMethylaMinopropyl)-N'-ethylcarbodiiMide >=97.0% (T)
  • 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide EDC EDAC
  • N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide(EDC)
  • ({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine
  • 1-(3-Dimethylaminopropyl)-3-
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 97%, for synthesis
  • 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide&gt
  • 1,3-Propanediamine, N3-(ethylcarbonimidoyl)-N1,N1-dimethyl-
  • N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, ≥97%
  • Avanafil Impurity 72
  • 1-ETHYL-(3- DIMETHYLAMINOPROPYL)CARBODIIMIDE (EDC Free Base)
  • 1-(3-Dimethylaminopropyl)-3- ethylcarb
  • n'-(ethylkohlenstoffimidoyl)-n,n-dimethylpropan-1,3-diamin
  • N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide
  • 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide
  • 1892-57-5
  • 25952-83-0
  • CH3CH2NCNCH23NCH32
  • C8H17N3
  • BioChemical
  • Carbodiimides
  • Reagents for Protein Sequencing
  • Protein Sequencing
  • Protein Analysis
  • Proteomics and Protein Expression
  • Synthetic Reagents
  • Coupling
  • straight chain compounds