ChemicalBook > CAS DataBase List > 2-Hydroxyphenylboronic acid

2-Hydroxyphenylboronic acid

Product Name
2-Hydroxyphenylboronic acid
CAS No.
89466-08-0
Chemical Name
2-Hydroxyphenylboronic acid
Synonyms
AKOS BRN-0196;2-Boronophenol;RARECHEM AH PB 0223;2-Hydroxyphenylboronic;2-Hydroxybenzeneboronic;Hydroxyphenylboronic Aci;2-hydroxyphenylboric acid;2-HYDROXYPHENYLBORONIC ACID;O-HYDROXYPHENYLBORONIC ACID;2-HYDROXYBENZENEBORONIC ACID
CBNumber
CB4412001
Molecular Formula
C6H7BO3
Formula Weight
137.93
MOL File
89466-08-0.mol
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2-Hydroxyphenylboronic acid Property

Melting point:
178-182°C
Boiling point:
327.3±44.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Acetonitrle (Slightly), DMSO (Slightly)
pka
8.61±0.58(Predicted)
form 
Powder
color 
White
Water Solubility 
Insoluble in water.
BRN 
2962938
InChI
InChI=1S/C6H7BO3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8-10H
InChIKey
YDMRDHQUQIVWBE-UHFFFAOYSA-N
SMILES
B(C1=CC=CC=C1O)(O)O
CAS DataBase Reference
89466-08-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-41-22
Safety Statements 
26-36/37/39
HazardClass 
IRRITANT
HS Code 
29319000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS000901
Product name
2-Hydroxyphenylboronic acid
Purity
Aldrich<SUP>CPR</SUP>
Packaging
250 mg
Price
$107
Updated
2025/07/31
TCI Chemical
Product number
H1184
Product name
2-Hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
1g
Price
$64
Updated
2025/07/31
TCI Chemical
Product number
H1184
Product name
2-Hydroxyphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$194
Updated
2025/07/31
TRC
Product number
H952913
Product name
2-Hydroxyphenylboronicacid
Packaging
1g
Price
$70
Updated
2021/12/16
TRC
Product number
H952913
Product name
2-Hydroxyphenylboronicacid
Packaging
100mg
Price
$45
Updated
2021/12/16
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2-Hydroxyphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

2-Hydroxyphenylboronic acid combines the aromaticity of the benzene ring with the special properties of boric acid in its structure, forming a unique molecular structure.

Uses

suzuki reaction

Uses

2-Hydroxybenzeneboronic acid is used as a pharmaceutical intermediate.

Synthesis

1034050-50-4

89466-08-0

General procedure for the synthesis of 2-hydroxyphenylboronic acid from 2-methoxyphenylboronic acid: 1.5 kg of 2-methoxyphenylboronic acid was added to a 30 L glass reactor under nitrogen protection, followed by 18 L of anisole and 1.56 kg of acetyl chloride. After the addition was completed, the reaction mixture was cooled to -10 to 0 °C and stirred at this temperature for 1 hour. Then, 133 g of anhydrous aluminum trichloride was added in batches. After the addition was completed, the reaction mixture was allowed to warm up naturally to room temperature and stirred continuously until the TLC detection showed that the reaction of the raw material was complete, a process that usually takes 8 to 10 hours. During the reaction, the solids in the reaction mixture were first gradually dissolved, followed by gradual precipitation of solids. Upon completion of the reaction, the reaction was quenched with 5 M aqueous potassium hydroxide and the pH was adjusted to 11 to 12. The organic layer was separated and discarded. The pH was adjusted to 2~3 by adding 6 M aqueous hydrochloric acid to the aqueous layer and then extracted twice with 12 L ethyl acetate, the organic layers were combined and washed with saturated brine. The organic layer was rotary evaporated to dryness and finally pulped with acetone/n-heptane to give 1.06 kg of 2-hydroxyphenylboronic acid in 77% yield and 98.6% HPLC purity.

References

[1] Patent: CN104788483, 2017, B. Location in patent: Paragraph 0018; 0019; 0020

2-Hydroxyphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxyphenylboronic acid Suppliers

Americas 1 Australia 1 China 307 Europe 2 France 3 Germany 9 India 6 Japan 3 Jordan 1 Russia 1 Ukraine 1 United Kingdom 8 United States 41 Global 384
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View Lastest Price from 2-Hydroxyphenylboronic acid manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Hydroxyphenylboronic acid 89466-08-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Henan Aochuang Chemical Co.,Ltd.
Product
2-Hydroxyphenylboronic acid 89466-08-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Hebei Yanxi Chemical Co., Ltd.
Product
2-Hydroxyphenylboronic acid 89466-08-0
Price
US $40.00-2.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-27

89466-08-0, 2-Hydroxyphenylboronic acidRelated Search:

Triclosan 2,3,4-Trihydroxybenzoic acid Ethyl 2-(Chlorosulfonyl)acetate Folic acid Glycine Phenylboronic acid Methylparaben 4'-Hydroxyacetophenone 4-Hydroxybenzaldehyde 4-Methoxyphenol 4-Hydroxybenzoic acid 2'-Hydroxy-3-phenylpropiophenone 2,4,6-TRIMETHOXYBENZENEBORONIC ACID 4-Boronophenol~4-Hydroxyphenylboronic acid,4-Hydroxyphenylboronic Acid (contains varying amounts of Anhydride),4-HYDROXYPHENYLBORONIC ACID 2-Fluorophenylboronic acid 5-BROMO-2-METHOXYPHENYLBORONIC ACID 2,4-Dimethoxybenzeneboronic acid 3-Hydroxyphenylboronic acid

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