ChemicalBook > CAS DataBase List > Levosulpiride

Levosulpiride

Product Name
Levosulpiride
CAS No.
23672-07-3
Chemical Name
Levosulpiride
Synonyms
Levosulpride;l-Form;rv-12309;Levopride;levopraid;l-Sulpirid;levosupride;l-Sulpiride;LEVOSULPIRIDE;(S)-(-)-Sulpir
CBNumber
CB4422019
Molecular Formula
C15H23N3O4S
Formula Weight
341.43
MOL File
23672-07-3.mol
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Levosulpiride Property

Melting point:
183-186 °C(lit.)
Density 
1.236±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
9.98±0.60(Predicted)
form 
Solid
color 
White to Off-White
Merck 
14,8989
InChIKey
BGRJTUBHPOOWDU-NSHDSACASA-N
CAS DataBase Reference
23672-07-3(CAS DataBase Reference)
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Safety

RIDADR 
3077
WGK Germany 
3
RTECS 
BZ3400100
HS Code 
29350090
Toxicity
LD50 oral in rabbit: > 1500mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7771
Product name
(S)-(?)-Sulpiride
Purity
≥98% (titration)
Packaging
5g
Price
$96.1
Updated
2024/03/01
Sigma-Aldrich
Product number
34002
Product name
(S)-(−)-Sulpiride
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$145
Updated
2024/03/01
Sigma-Aldrich
Product number
5.05626
Product name
(S)-Sulpiride - CAS 23672-07-3 - Calbiochem
Packaging
100mg
Price
$82.2
Updated
2022/05/15
TCI Chemical
Product number
I0821
Product name
(S)-(-)-Sulpiride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$108
Updated
2024/03/01
TCI Chemical
Product number
I0821
Product name
(S)-(-)-Sulpiride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$271
Updated
2024/03/01
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Levosulpiride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(S)-(?)-Sulpiride was used to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels10 and on depression-like behavior in ovariectomized female rats.11

Uses

dopamine receptor antagonists

Uses

Dopamine D2 and D3-receptor antagonist. Antipsychotic; antidepressant; antiemetic.

Definition

ChEBI: An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, 1 and D5 receptors respectively).

General Description

(S)-(?)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders.

Biological Activity

Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).

Biochem/physiol Actions

(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9

storage

Room temperature

Levosulpiride Preparation Products And Raw materials

Raw materials

Lithium tert-butoxide Ethanol Aminosulfonate Sulpiride (S)-2-(Aminomethyl)-1-ethylpyrrolidine 2-(Aminomethyl)-1-ethylpyrrolidine L-Proline Lithium Aluminum Hydride Sodium hydroxide L(+)-Tartaric acid Methyl benzoate

Preparation Products

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Levosulpiride Suppliers

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View Lastest Price from Levosulpiride manufacturers

Hong Kong Excellence Biotechnology Co., Ltd.
Product
Levosulpiride 23672-07-3
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-10-12
Sigma Audley
Product
Levosulpiride 23672-07-3
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
200tons/year
Release date
2024-03-15
Sigma Audley
Product
Levosulpiride 23672-07-3
Price
US $45.00-35.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
200tons/year
Release date
2024-01-16

23672-07-3, LevosulpirideRelated Search:

METSULFURON METHYL Bensulfuron methyl Amisulpride Thiophanate-methyl Methyl acetate Chlorantraniliprole Methyl acrylate Benzamide Kresoxim-methyl Methylparaben Calcium levofolinate Levomilnacipran Levothyroxine sodium L(+)-Tartaric acid Methyl L(-)-Carvone Levodopa L(-)-Carnitine hydrochloride

  • (s)-(-)-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide
  • (s)-(-)-o-anisamid
  • (S)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide
  • China (S)-(-)-Sulpiride
  • Levosulpiride, (S)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
  • S-(-)-Sulpiride，Levobren，Levopraid
  • (s)-(-)-n-((1-ethyl-2-pyrrolidinyl)methyl)-5-sulfamoyl-o-anisamide 5-(aminosulfonyl)-n-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-benzamid ( s-(-)-benzamid
  • rv-12309 s-(-)-n-(1-ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoylebenzamide
  • s-(-)-sulpiride (S)--5-Aminosulfonyl-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxybenzamide
  • levosupride
  • (S)-(-)-5-(Aminoulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
  • Levopride
  • 5-(AMinosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]Methyl]-2-Methoxy-benzaMide
  • 5-(AMinosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]Methyl]-2-benzaMide
  • l-Sulpirid
  • (S)-N-[(1-Ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoylbenzamide Levosulpiride
  • (S)-(-)-5-(aMinosulfonyl)-N-[(1-ethyl-2-pyrrolinyl)Methyl]
  • Levosulpiride (Irritable Bowel SyndroMe)
  • (S)-(-)-Sulpir
  • (S)-(-)-SULPIRIDE
  • (S)-(-)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXYBENZAMIDE
  • 5-(aminosulfonyl)-n-((1-ethyl-2-pyrrolidinyl)methyl)-2-methoxy-benzamid(
  • levopraid
  • rv-12309
  • s-(-)-n-(1-ethyl-2-pyrrolidinomethyl)-2-methoxy-5-sulfamoylebenzamide
  • (-)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXY-BENZAMIDE
  • Levosulpride
  • (S)-(-)-Sulpiride, Vetranal
  • S(-)-SULPIRIDE DOPAMINE D1 ANTAGONIS
  • LEVOSULPIRIDE/LEVOSULPRIDE
  • Benzamide, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-, (S)-
  • Benzamide, 5-(aminosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-methoxy- (9CI)
  • l-Sulpiride
  • (S)-5-AMINOSULFONYL-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-2-METHOXYBENZAMIDE
  • (-)-N-1-[ETHYLPYRROLIDIN-2-YLMETHYL]-2-METHOXY-5-SULFAMOYLBENZAMIDE
  • LEVOSULPIRIDE
  • (S)-(-)-Sulpiride, 98%, a selective antagonist for D2 dopamine receptor
  • l-Form
  • LEVOSULPIRIDE (RV-12309)
  • Left-handed sulpiride
  • (S)-(-)-Sulpiride&gt
  • Benzamide, 5-(aminosulfonyl)-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-methoxy-
  • Levosulpiride USP/EP/BP
  • L-Sulpiride Impurity
  • LevosulpirideQ: What is Levosulpiride Q: What is the CAS Number of Levosulpiride Q: What is the storage condition of Levosulpiride Q: What are the applications of Levosulpiride
  • LevosulprideQ: What is Levosulpride Q: What is the CAS Number of Levosulpride
  • Lform of Sulpiride
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  • LEVOSULPRIDE 60% SR PELLETS
  • Caprylic Acid Impurity 36
  • (S)-Sulpiride, D2-like dopamine antagonist
  • 23672-07-3
  • C15H23N3O4O4
  • Analytical Standards
  • Analytical Chromatography Product Catalog
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  • Dopamine receptor