ChemicalBook > CAS DataBase List > Levosulpiride

Levosulpiride

Product Name
Levosulpiride
CAS No.
23672-07-3
Chemical Name
Levosulpiride
Synonyms
Levosulpride;l-Form;rv-12309;Levopride;levopraid;l-Sulpirid;levosupride;l-Sulpiride;LEVOSULPIRIDE;(S)-(-)-Sulpir
CBNumber
CB4422019
Molecular Formula
C15H23N3O4S
Formula Weight
341.43
MOL File
23672-07-3.mol
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Levosulpiride Property

Melting point:
183-186 °C(lit.)
Density 
1.236±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
9.98±0.60(Predicted)
form 
Solid
color 
White to Off-White
Merck 
14,8989
InChIKey
BGRJTUBHPOOWDU-NSHDSACASA-N
CAS DataBase Reference
23672-07-3(CAS DataBase Reference)
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Safety

RIDADR 
3077
WGK Germany 
3
RTECS 
BZ3400100
HS Code 
29350090
Toxicity
LD50 oral in rabbit: > 1500mg/kg
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7771
Product name
(S)-(?)-Sulpiride
Purity
≥98% (titration)
Packaging
5g
Price
$96.1
Updated
2024/03/01
Sigma-Aldrich
Product number
34002
Product name
(S)-(−)-Sulpiride
Purity
VETRANAL?, analytical standard
Packaging
100mg
Price
$145
Updated
2024/03/01
Sigma-Aldrich
Product number
5.05626
Product name
(S)-Sulpiride - CAS 23672-07-3 - Calbiochem
Packaging
100mg
Price
$82.2
Updated
2022/05/15
TCI Chemical
Product number
I0821
Product name
(S)-(-)-Sulpiride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$108
Updated
2024/03/01
TCI Chemical
Product number
I0821
Product name
(S)-(-)-Sulpiride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$271
Updated
2024/03/01
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Levosulpiride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(S)-(?)-Sulpiride was used to study the effect of dopamine D2 receptor function on activation of KCNQ potassium channels10 and on depression-like behavior in ovariectomized female rats.11

Uses

dopamine receptor antagonists

Uses

Dopamine D2 and D3-receptor antagonist. Antipsychotic; antidepressant; antiemetic.

Definition

ChEBI: An optically active form of sulpiride having (S)-configuration. The active enantiomer of the racemic drug sulpiride. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 muM at D2, D3, D4, 1 and D5 receptors respectively).

General Description

(S)-(?)-Sulpiride is a levorotatory enantiomer of sulpiride, which shows greater central antidopaminergic activity, antiemetic and antidyspeptic effects. It is also used as a therapeutic drug for the treatment of depression and somatoform disorders.

Biological Activity

Active enantiomer. Selective D 2 -like dopamine antagonist (K i values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μ M at D 2 , D 3 , D 4 , D 1 and D 5 receptors respectively).

Biochem/physiol Actions

(S)-(?)-Sulpiride or Levosulpiride blocks the inhibitory enteric D2 receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.7,8 Since dopamine controls human sexual function, (S)-(?)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.9

storage

Room temperature

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View Lastest Price from Levosulpiride manufacturers

Hong Kong Excellence Biotechnology Co., Ltd.
Product
Levosulpiride 23672-07-3
Price
US $100.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
20tons
Release date
2023-10-12
Sigma Audley
Product
Levosulpiride 23672-07-3
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
200tons/year
Release date
2024-03-15
Sigma Audley
Product
Levosulpiride 23672-07-3
Price
US $45.00-35.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
200tons/year
Release date
2024-01-16

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