ChemicalBook > CAS DataBase List > 2-(2-Methoxyethoxy)acetic acid

2-(2-Methoxyethoxy)acetic acid

Product Name
2-(2-Methoxyethoxy)acetic acid
CAS No.
16024-56-9
Chemical Name
2-(2-Methoxyethoxy)acetic acid
Synonyms
DOHA;TIMTEC-BB SBB008497;2-(2-Methoxyoxyacid;3,6-DIOXAHEPTANOIC ACID;2-(2-Methoxyethoxy)Acetic;(2-Methoxyethoxy)essigsure;(2-methoxyethoxy)acetic acid;2-(2-METHOXYETHOXY)ACETIC ACID;o-(2-methoxyethyl)glycolic acid;2-(2-methoxyethoxy)ethanoic acid
CBNumber
CB4434197
Molecular Formula
C5H10O4
Formula Weight
134.13
MOL File
16024-56-9.mol
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2-(2-Methoxyethoxy)acetic acid Property

Boiling point:
245-250 °C (lit.)
Density 
1.18 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.436(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Chloroform, DMSO, Methanol
form 
Oil
pka
3.40±0.10(Predicted)
color 
Clear Colourless
Water Solubility 
Fully miscible in water.
BRN 
1753567
InChIKey
CLLLODNOQBVIMS-UHFFFAOYSA-N
CAS DataBase Reference
16024-56-9(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3265 8/PG 2
WGK Germany 
1
HazardClass 
8
PackingGroup 
II
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
407011
Product name
2-(2-Methoxyethoxy)acetic acid
Purity
technical grade
Packaging
250ml
Price
$357
Updated
2025/07/31
Sigma-Aldrich
Product number
407011
Product name
2-(2-Methoxyethoxy)acetic acid
Purity
technical grade
Packaging
1l
Price
$933
Updated
2023/06/20
TRC
Product number
M262785
Product name
2-(2-Methoxyethoxy)aceticAcid(90%)
Packaging
10g
Price
$110
Updated
2021/12/16
TRC
Product number
M262785
Product name
2-(2-Methoxyethoxy)aceticAcid(90%)
Packaging
100g
Price
$350
Updated
2021/12/16
Matrix Scientific
Product number
143402
Product name
2-(2-Methoxyethoxy)acetic acid
Purity
97%
Packaging
1g
Price
$34
Updated
2021/12/16
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2-(2-Methoxyethoxy)acetic acid Chemical Properties,Usage,Production

Chemical Properties

Colorless to pale yellow liquid

Uses

2-(2-Methoxyethoxy)acetic Acid is a urinary metabolite of Diglyme (D446300) that is a reproductive toxin. 2-(2-Methoxyethoxy)acetic Acid can be used as a biomarker of exposure for jet fuel JP-8 workers.

Synthesis

109-86-4

5292-43-3

16024-56-9

General procedure for the synthesis of methoxyethoxyacetic acid from 2-methoxyethanol and tert-butyl bromoacetate: 2-methoxyethanol (10 g, 131.4 mmol) and potassium tert-butoxide (17.67 g, 157.68 mmol) were dissolved in 100 mL of tetrahydrofuran (THF). The reaction mixture was heated to 45 °C, maintained for 1 h and then cooled to room temperature. To the above mixture was added tert-butyl bromoacetate (25.63 g, 131.41 mmol) and the reaction was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in water. The pH of the aqueous phase was adjusted to 12-12.5 with 1 M sodium hydroxide aqueous solution and stirring was continued for 12-14 hours at room temperature. Subsequently, the pH of the aqueous phase was adjusted with 10% aqueous phosphoric acid solution to 2. The product was extracted with dichloromethane (DCM). The DCM was removed by rotary evaporator to give 2-(2-methoxyethoxy)acetic acid as an oil (4.1 g, 23% yield).

References

[1] Patent: WO2015/79459, 2015, A1. Location in patent: Paragraph 00261

2-(2-Methoxyethoxy)acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(2-Methoxyethoxy)acetic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-(2-Methoxyethoxy)acetic acid 16024-56-9
Price
US $0.00/G
Min. Order
100G
Purity
90%min
Supply Ability
30KG/month
Release date
2023-02-02
Career Henan Chemical Co
Product
2-(2-Methoxyethoxy)acetic acid 16024-56-9
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

16024-56-9, 2-(2-Methoxyethoxy)acetic acidRelated Search:

(Trifluoromethoxy)benzene Guaiacol Ethoxyacetic acid p-Anisidine Anisole 4-Methoxyphenol Ethyl 2-(Chlorosulfonyl)acetate p-Anisaldehyde Ethoxyquin m-PEG2-acid 4-(2-METHOXY-ETHOXY)-BENZALDEHYDE 1-Bromo-2-(2-methoxyethoxy)ethane m-PEG2-Azide 2-METHOXYETHYL P-TOLUENESULFONATE 2-(2-Methoxyethoxy)ethanamine 2,5-Dioxopyrrolidin-1-yl 3-(2-methoxyethoxy)propanoate 2-(2-METHOXYETHOXY)ETHANETHIOL 97 1H-Pyrrole-1-propanamide, 2,5-dihydro-N-[2-(2-methoxyethoxy)ethyl]-2,5-dioxo-

  • TIMTEC-BB SBB008497
  • 3,6-DIOXAHEPTANOIC ACID
  • 2-(2-METHOXYETHOXY)ACETIC ACID
  • (2-methoxyethoxy)acetic acid
  • 2-(2-METHOXYETHOXY)ACETIC ACID, TECH.
  • 2-(2-Methoxyethoxy)Acetic
  • o-(2-methoxyethyl)glycolic acid
  • (2-Methoxyethoxy)essigsure
  • 2-(2-METHOXYETHOXY)ACETIC ACID TECH 90+%
  • DOHA
  • 2-(2-Methoxyethoxy)acetic acid technical grade
  • 2-(2-methoxyethoxy)ethanoic acid
  • 2-(2-Methoxyethoxy)acetic Acid (90%)
  • Acetic acid, 2-(2-methoxyethoxy)-
  • 2-(2-Methoxyethoxy)acetic acid, tech grade
  • 2-(2-Methoxyoxyacid
  • 2-(2-methoxyethoxy)acetic acid 90%
  • (2-Methoxyethoxy)acetic acid (90%)
  • 16024-56-9
  • CH3OCH22OCH2CO2H
  • CH3OCH2CH2OCH2CO2H
  • C5H9O4
  • CARBOXYLIC ACID
  • Heterocyclic Compounds