ChemicalBook > CAS DataBase List > 5-Chloro-8-hydroxyquinoline

5-Chloro-8-hydroxyquinoline

Product Name
5-Chloro-8-hydroxyquinoline
CAS No.
130-16-5
Chemical Name
5-Chloro-8-hydroxyquinoline
Synonyms
Cloxyquin;Cloxiquin;cloxiquine;5-CHLORO-8-QUINOLINOL;Cloxyqui;Chlorisept;Cloxyquine;Dermofungin;DERMOFONGIN;5-CHLOROOXINE
CBNumber
CB4434834
Molecular Formula
C9H6ClNO
Formula Weight
179.6
MOL File
130-16-5.mol
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5-Chloro-8-hydroxyquinoline Property

Melting point:
122-124 °C(lit.)
Boiling point:
348.7±22.0 °C(Predicted)
Density 
1.2364 (rough estimate)
vapor pressure 
0.003Pa at 25℃
refractive index 
1.5330 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
0.019g/l (experimental)
form 
Powder
pka
3.77±0.10(Predicted)
color 
Light green to gray
Sensitive 
Light Sensitive
Merck 
14,2422
BRN 
5289
InChIKey
RWPWQYXFGFYJBA-UHFFFAOYSA-N
CAS DataBase Reference
130-16-5(CAS DataBase Reference)
NIST Chemistry Reference
8-Quinolinol, 5-chloro-(130-16-5)
EPA Substance Registry System
8-Quinolinol, 5-chloro- (130-16-5)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
RTECS 
VC4590000
TSCA 
Yes
HS Code 
29334990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C47000
Product name
5-Chloro-8-quinolinol
Purity
95%
Packaging
100g
Price
$56.56
Updated
2025/07/31
TCI Chemical
Product number
C0645
Product name
5-Chloro-8-hydroxyquinoline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
C0645
Product name
5-Chloro-8-hydroxyquinoline
Purity
>98.0%(GC)(T)
Packaging
250g
Price
$158
Updated
2025/07/31
Usbiological
Product number
163644
Product name
Dermofungin
Packaging
1g
Price
$403
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK910691
Product name
5-Chloro-8-hydroxyquinoline
Purity
95%
Packaging
25g
Price
$14
Updated
2021/12/16
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5-Chloro-8-hydroxyquinoline Chemical Properties,Usage,Production

Chemical Properties

light green to grey powder

Uses

antibacterial, antifungal

Uses

Dermofungin, is an impurity of Cioquinol, which is an antifungal and antiprotozoal drug.

Definition

ChEBI: Cloxiquine is a member of quinolines and an organochlorine compound.

Synthesis Reference(s)

The Journal of Organic Chemistry, 70, p. 8590, 2005 DOI: 10.1021/jo051191x

Synthesis

3054-95-3

95-85-2

130-16-5

GENERAL PROCEDURE: A 1N HCl solution (82.5 mL) was added to a round-bottomed flask containing 4-chloro-2-aminophenol (~1 mmol). Acrolein diethyl acetal (2.5 mmol) was added to the reaction mixture. The resulting solution was refluxed at 111°C for 24 hours. Upon completion of the reaction, the mixture was cooled to room temperature and neutralized to pH 7-8 with solid Na2CO3. Subsequently, the product was extracted with dichloromethane (3 x 100 mL), the organic layers were combined and dried with anhydrous Na2SO4. After removal of solvent by evaporation under reduced pressure, the crude product was purified by column chromatography with the eluent being a mixture of 15% ethyl acetate/cyclohexane and methanol to afford the target compound 5-chloro-8-hydroxyquinoline.

in vitro

Cloxiquine (cloxyquin) exhibits antituberculosis activities, with MICs ranging from 0.062 to 0.25 μg/mL against 9 standard strains and 150 Mycobacterium tuberculosis .
Cloxiquine (0.5-10 μM; 24 h) suppresses both B16F10 and A375 cell growth in a dose-dependent manner.|
Cloxiquine (0.5-10 μM; 24 h) inhibits the migration of B16F10 and A375 cells.
Cloxiquine (0.5-2.5 μM; 24 h) suppresses glycolysis in B16F10 cells.

in vivo

Cloxiquine (5-25 mg/kg; i.p. daily for 8 d) suppresses tumor growth in a mouse B16F10 melanoma xenograft model.
Cloxiquine (5-25 mg/kg; i.p. daily for 14 d) suppresses tumor metastasis in mouse B16F10 melanoma lung metastatic model.

References

[1] Tetrahedron Letters, 2015, vol. 56, # 46, p. 6436 - 6439

5-Chloro-8-hydroxyquinoline Preparation Products And Raw materials

Raw materials

8-Hydroxyquinoline

Preparation Products

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5-Chloro-8-hydroxyquinoline Suppliers

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View Lastest Price from 5-Chloro-8-hydroxyquinoline manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
5-Chloro-8-hydroxyquinoline 130-16-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-19
Hebei Fengjia New Material Co., Ltd
Product
5-Chloro-8-hydroxyquinoline 130-16-5
Price
US $30.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100 tons
Release date
2024-08-14
Hebei Chuanghai Biotechnology Co., Ltd
Product
5-Chloro-8-hydroxyquinoline 130-16-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31

130-16-5, 5-Chloro-8-hydroxyquinolineRelated Search:

8-Hydroxyquinoline Quinhydrone 5,7-Dichloro-8-hydroxyquinoline 5,7-Dichloro-8-hydroxyquinaldine Cloquintocet-mexyl 7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE 98+%,7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE PEST ANAL,7-BROMO-5-CHLORO-8-HYDROXYQUINOLINE Difluorochloromethane 7-IODO-5-CHLORO-8-HYDROXYQUINOLINE 97%,7-IODO-5-CHLORO-8-HYDROXYQUINOLINE,N-IODO-5-CHLORO-8-HYDROXYQUINOLINE 7-CHLORO-4-HYDROXYQUINOLINE,7-CHLORO-4-HYDROXYQUINOLINE, 98+%,7-CHLORO-4-HYDROXYQUINOLINE 97+% 6-CHLORO-4-HYDROXYQUINOLINE 7-CHLORO-4-HYDROXY QUINOLINE-3-CARBOXYLIC ACID 4-CHLORO-2-HYDROXYQUINOLINE 5,7-DICHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 6-CHLORO-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID 5,8-DICHLORO-4-HYDROXYQUINOLINE 8-CHLORO-2-HYDROXYQUINOLINE 7-CHLORO-2-HYDROXYQUINOLINE,7-CHLORO-2-HYDROXYQUINOLINE, 98+% 5-AMINO-3-ISOPROPYL-1,2,4-THIADIAZOLE

  • 5-Chloro-8-quinolinol, >=98%
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  • Manufacturer Supplying High Quality?5-Chloro-8-Hydroxyquinoline CAS:?130-16-5
  • 5-Chloro-8-hydroxyquinolineQ: What is 5-Chloro-8-hydroxyquinoline Q: What is the CAS Number of 5-Chloro-8-hydroxyquinoline Q: What is the storage condition of 5-Chloro-8-hydroxyquinoline
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  • 130-16-5
  • C9H6NOCl
  • Building Blocks
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  • 130-16-5