Pleuromulin

Product Name: Pleuromulin
CAS No.: 125-65-5
Chemical Name: Pleuromulin
Synonyms: bc757;a4014c;Tymosin;NSC 121145;PLEUROMULIN;drosopholinb;Drosophilin B;PLEUROMUTILIN;antibioticbc757;Truncate pleurotin
CBNumber: CB4436641
Molecular Formula: C22H34O5
Formula Weight: 378.5
MOL File: 125-65-5.mol

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Pleuromulin Property

Melting point:: 170-1710C
alpha: D24 +20° (c = 3 in abs ethanol)
Boiling point:: 482.8±45.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO: >10mg/mL (warmed)
form: powder
pka: 12.91±0.10(Predicted)
color: white to beige
optical activity: [α]/D +30 to +40° (c=1; CH2Cl2)
InChIKey: YSBXUHAJXRCCET-BKUNHTPHSA-N

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Safety

WGK Germany: 3
RTECS: MC5408000
Toxicity: LD50 in mice: >60 mg/kg (Kavanagh, 1952)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0285
Product name: Pleuromutilin
Purity: ≥95%
Packaging: 5mg
Price: $144
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000586
Product name: Valnemulin impurity E
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000586
Price: $223
Updated: 2024/03/01

Cayman Chemical

Product number: 19452
Product name: Pleuromutilin
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 19452
Product name: Pleuromutilin
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0285
Product name: Pleuromutilin
Purity: ≥95%
Packaging: 25mg
Price: $568
Updated: 2024/03/01

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Pleuromulin Chemical Properties,Usage,Production

Description

Pleuromutilin is an antibiotic derived from the fungus Clitopilus that inhibits bacterial protein synthesis by binding to bacterial ribosomes in the peptidyl transferase component of the 50S subunit and inhibiting peptide bond formation.

Chemical Properties

Pleuromulin is Crystalline Solid

Uses

Antibiotic substance produced by the basidiomycetes Pleurotus mutilus.

Uses

Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
Pleuromutilins such as tiamulin and valnemulin have been used for some time in veterinary medicine to treat swine infections. More recently a semisynthetic pleuromutilin, retapamulin, has been introduced as a topical treatment for Gram-positive infections in humans. Pleuromutilins inhibit the peptidyl transferase activity of the bacterial 50S ribosomal subunit by binding to the A site.

References

[1]. kilaru s, collins cm, hartley aj, et al. establishing molecular tools for genetic manipulation of the pleuromutilin-producing fungus clitopilus passeckerianus. appl environ microbiol. 2009 nov;75(22):7196-204.
[2]. long ks, hansen lh, jakobsen l, et al. interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center. antimicrob agents chemother. 2006 apr;50(4):1458-62.

Pleuromulin Preparation Products And Raw materials

Raw materials

Preparation Products

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Pleuromulin Suppliers

Canada 1 China 228 Germany 1 India 3 United Kingdom 5 United States 18 Global 256

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View Lastest Price from Pleuromulin manufacturers

Hebei Fengjia New Material Co., Ltd

Product: Pleuromulin 125-65-5
Price: US $30.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2024-08-14

Hebei Weibang Biotechnology Co., Ltd

Product: Pleuromulin 125-65-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-09-03

Hebei Mojin Biotechnology Co., Ltd

Product: antibioticbc757 125-65-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-30

125-65-5, PleuromulinRelated Search:

Florfenicol Doxycycline Colistin sulfate Enrofloxacin Tylosin Ofloxacin Tilmicosin Ceftiofur sodium Amoxicillin Roxithromycin Tiamulin CHLOROPHOSPHONAZO III Tiamulin fumarate CYCLOUNDECANONE 2-Iso-butylcyclopentanone VINYLCYCLOOCTANE Pleuromulin

PLEUROMULIN

PLEUROMUTILIN

a4014c

antibioticbc757

bc757

drosopholinb

glycolicacid,8-esterwithoctahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-viny

l-3a,9-propano-3ah-cyclopentacycloocten-1(4h)-one

2-Hydroxyacetic Acid (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl Ester

5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate

Drosophilin B

Acetic acid, 2-hydroxy-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

Glycolic acid, 8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3aH-cyclopentacycloocten-1(4H)-one

Glycolic acid (10R)-6-ethenyldecahydro-5α-hydroxy-4β,6β,9β,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten-8β-yl

Glycolic acid (10R)-6-ethenyldecahydro-5α-hydroxy-4β,6β,9β,10-tetramethyl-1-oxo-3aα,9α-propano-3aH-cyclopentacycloocten-8β-yl ester

PleuroMutilin antibacterial drugs

PleuroMulin 95% 97%

Drosophilin B, A 40104C

Mutilin 14-glycolate

NSC 121145

Tiamulin EP Impurity G

Pleuromulin Manufacturer / In stock factory

Valnemulin impurity E CRS

Truncate pleurotin

Valnemulin hydrochloride EP Impurity E

(3aS，4R，5S，6S，8R，9R，9aR，12R)-5-Hydroxy-4，6，9，12-tetramethyl-1-oxo-6-vinyldecahydro-3a，9-propanocyclopenta[8]annulen-8-yl 2-hydroxyacetate

Acetic acid, hydroxy-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester

(2R,3S,4S,6R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.01,?]tetradecan-6-yl 2-hydroxyacetate

PleuromutilinQ: What is Pleuromutilin Q: What is the CAS Number of Pleuromutilin Q: What is the storage condition of Pleuromutilin Q: What are the applications of Pleuromutilin

Tymosin

Pleuromutilin (6CI, 7CI)

Tiamulin Hydrogen Fumarate Impurity G

Valnemulin Hydrochloride Impurity E

Tiamulin Hydrogen Fumarate EP Impurity G

Tiamulin Impurity 7 (Tiamulin EP Impurity G)

Truncated pleurotin

Tiamulin EP Impurity G (Valnemulin EP Impurity E)

(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-Hydroxyacetate

Truncated lateral ear extract

Codeine Phosphate Impurity 6 (Codeine Phosphate EP Impurity F)

Truncated Pleurotus toxin

125-65-5

Intermediates & Fine Chemicals

Pharmaceuticals