ChemicalBook > CAS DataBase List > Z-VAL-NH2

Z-VAL-NH2

Product Name: Z-VAL-NH2
CAS No.: 13139-28-1
Chemical Name: Z-VAL-NH2
Synonyms: Z-VAL-NH2;Z-L-Val-NH2;CBZ-Val-NH2;Cbz-L-Val-NH2;Z-L-VALINE AMIDE;CBZ-L-VALINE AMIDE;N-Cbz-L-valinamide;Z-VAL-NH2 USP/EP/BP;Benzyloxycarbonyl-L-valinamide;N-Benzyloxycarbonylvaline amide
CBNumber: CB4438832
Molecular Formula: C13H18N2O3
Formula Weight: 250.29
MOL File: 13139-28-1.mol

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Z-VAL-NH2 Property

Boiling point:: 452.2±38.0 °C(Predicted)
Density: 1.144±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: Solid
pka: 11.09±0.46(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: V963035
Product name: Z-Val-NH2
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 292018
Product name: Z-L-valine amide
Packaging: 2g
Price: $347
Updated: 2021/12/16

AK Scientific

Product number: Z9569
Product name: Z-Val-NH2
Packaging: 25g
Price: $145
Updated: 2021/12/16

AK Scientific

Product number: J97114
Product name: Z-Val-NH2
Packaging: 100g
Price: $338
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4656-1-SD
Product name: Benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate; (S)-N-(Benzyloxycarbonyl)valinamide
Packaging: 500mg
Price: $104
Updated: 2021/12/16

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Z-VAL-NH2 Chemical Properties,Usage,Production

Synthesis

1149-26-4

13139-28-1

The general procedure for the synthesis of benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate from CBZ-L-valine was as follows: to a solution of compound I (10 g, 39.84 mmol, 1 eq.) in DMF (100 mL) at 0 °C was added sequentially DIPEA (19.7 mL, 119.5 mmol, 3 eq. ) and HATU (18.17 g, 47.8 mmol, 1.2 eq.). The reaction mixture was stirred for 15 minutes. Subsequently, ammonium chloride (10.7 g, 199.2 mmol, 5 eq.) was added to the mixture and the reaction mixture was continued to be stirred at 23 °C for 16 hours. Upon completion of the reaction, the mixture was poured into ice-cold water (500 mL) and the organic components were extracted with EtOAc (3 x 500 mL). The combined organic layers were washed sequentially with aqueous ammonium chloride and brine, then dried over anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by ethanol recrystallization to afford the target product (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamic acid benzyl ester (9.8 g, 98% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.35 (m, 6H), 7.12 (d, 1H, J = 9Hz), 7.01 (s, 1H), 5.03 (s, 2H), 3.80 (t, 1H, J = 8Hz), 1.95 (m, 1H), 0.85 (m, 6H).LCMS analysis: m/z = 251.2 [M + H], retention time RT = 2.81 min (program P1, column Y).

References

[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0195; 0196; 0197
[2] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[3] Chemische Berichte, 1983, vol. 116, # 5, p. 2037 - 2040
[4] Tetrahedron Letters, 1995, vol. 36, # 39, p. 7115 - 7118
[5] Chemical Communications, 2017, vol. 53, # 75, p. 10362 - 10365

Z-VAL-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Z-VAL-NH2 manufacturers

Career Henan Chemical Co

Product: Z-VAL-NH2 13139-28-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99.99%
Supply Ability: 1kg-10MT
Release date: 2019-05-24

13139-28-1, Z-VAL-NH2Related Search:

Z-VAL-PHE-OH Z-VAL-OSU Z-VAL-GLY-OH Z-VAL-ONP Z-VAL-PRO-OH N-Carbobenzyloxy-L-valine Z-TYR-OH Z-TLE-OH DCHA Z-TRP-OME Z-TYR(TBU)-OSU Z-TYR-ONP Z-TYR-OME Z-L-Valine NCA Z-VAL-OET Z-VAL-PHE-OME Z-VAL-ALA-OH Z-VAL-SER-OH CBZ-L-VALINE METHYL ESTER

N-Benzyloxycarbonyl-L-valinamide

N-Benzyloxycarbonylvaline amide

Benzyloxycarbonyl-L-valinamide

(S)-N-Benzoyloxycarbonyl valinamide

Z-L-Val-NH2

N-ALPHA-CARBOBENZOXY-L-VALINE AMIDE

Z-L-VALINE AMIDE

Z-VAL-NH2

CBZ-L-VALINE AMIDE

(S)-benzyl 1-amino-3-methyl-1-oxobutan-2-ylcarbamate

CBZ-Val-NH2

(S)-N-(Benzyloxycarbonyl)valinamide

Benzyl(S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate

benzyl N-[(1S)-1-carbamoyl-2-methylpropyl]carbamate

N-Cbz-L-valinamide

Carbamic acid, N-[(1S)-1-(aminocarbonyl)-2-methylpropyl]-, phenylmethyl ester

benzylN-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate

Z-VAL-NH2 USP/EP/BP

Cbz-L-Val-NH2

13139-28-1