Z-VAL-NH2
- Product Name
- Z-VAL-NH2
- CAS No.
- 13139-28-1
- Chemical Name
- Z-VAL-NH2
- Synonyms
- Z-VAL-NH2;Z-L-Val-NH2;CBZ-Val-NH2;Cbz-L-Val-NH2;Z-L-VALINE AMIDE;CBZ-L-VALINE AMIDE;N-Cbz-L-valinamide;Z-VAL-NH2 USP/EP/BP;Benzyloxycarbonyl-L-valinamide;N-Benzyloxycarbonylvaline amide
- CBNumber
- CB4438832
- Molecular Formula
- C13H18N2O3
- Formula Weight
- 250.29
- MOL File
- 13139-28-1.mol
Z-VAL-NH2 Property
- Boiling point:
- 452.2±38.0 °C(Predicted)
- Density
- 1.144±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- form
- Solid
- pka
- 11.09±0.46(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- V963035
- Product name
- Z-Val-NH2
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 292018
- Product name
- Z-L-valine amide
- Packaging
- 2g
- Price
- $347
- Updated
- 2021/12/16
- Product number
- 12362
- Product name
- Z-L-valineamide,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 1G
- Price
- $34.83
- Updated
- 2021/12/16
- Product number
- 4656-1-SD
- Product name
- Benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate; (S)-N-(Benzyloxycarbonyl)valinamide
- Packaging
- 500mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 12362
- Product name
- Z-L-valineamide,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 5G
- Price
- $110.1
- Updated
- 2021/12/16
Z-VAL-NH2 Chemical Properties,Usage,Production
Synthesis
1149-26-4
13139-28-1
The general procedure for the synthesis of benzyl (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamate from CBZ-L-valine was as follows: to a solution of compound I (10 g, 39.84 mmol, 1 eq.) in DMF (100 mL) at 0 °C was added sequentially DIPEA (19.7 mL, 119.5 mmol, 3 eq. ) and HATU (18.17 g, 47.8 mmol, 1.2 eq.). The reaction mixture was stirred for 15 minutes. Subsequently, ammonium chloride (10.7 g, 199.2 mmol, 5 eq.) was added to the mixture and the reaction mixture was continued to be stirred at 23 °C for 16 hours. Upon completion of the reaction, the mixture was poured into ice-cold water (500 mL) and the organic components were extracted with EtOAc (3 x 500 mL). The combined organic layers were washed sequentially with aqueous ammonium chloride and brine, then dried over anhydrous sodium sulfate, filtered and concentrated to dryness. The crude product was purified by ethanol recrystallization to afford the target product (S)-(1-amino-3-methyl-1-oxobutan-2-yl)carbamic acid benzyl ester (9.8 g, 98% yield) as an off-white solid. The product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.35 (m, 6H), 7.12 (d, 1H, J = 9Hz), 7.01 (s, 1H), 5.03 (s, 2H), 3.80 (t, 1H, J = 8Hz), 1.95 (m, 1H), 0.85 (m, 6H).LCMS analysis: m/z = 251.2 [M + H], retention time RT = 2.81 min (program P1, column Y).
References
[1] Patent: WO2015/95128, 2015, A1. Location in patent: Paragraph 0195; 0196; 0197
[2] Tetrahedron Asymmetry, 2017, vol. 28, # 12, p. 1690 - 1699
[3] Chemische Berichte, 1983, vol. 116, # 5, p. 2037 - 2040
[4] Tetrahedron Letters, 1995, vol. 36, # 39, p. 7115 - 7118
[5] Chemical Communications, 2017, vol. 53, # 75, p. 10362 - 10365
Z-VAL-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
Z-VAL-NH2 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from Z-VAL-NH2 manufacturers
- Product
- Z-VAL-NH2 13139-28-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99.99%
- Supply Ability
- 1kg-10MT
- Release date
- 2019-05-24