REVEROMYCIN A

Product Name: REVEROMYCIN A
CAS No.: 134615-37-5
Chemical Name: REVEROMYCIN A
Synonyms: REVEROMYCIN A;ZESGNAJSBDILTB-OXVOKJAASA-N;Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester
CBNumber: CB4443481
Molecular Formula: C36H52O11
Formula Weight: 660.79
MOL File: 134615-37-5.mol

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REVEROMYCIN A Property

Boiling point:: 849.0±65.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMF: soluble
form: solid
pka: 4.36±0.17(Predicted)
color: tan

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R0654
Product name: Reveromycin A
Purity: solid
Packaging: 100μg
Price: $350
Updated: 2025/07/31

Cayman Chemical

Product number: 17458
Product name: Reveromycin A
Purity: ≥99%
Packaging: 250μg
Price: $353
Updated: 2024/03/01

Cayman Chemical

Product number: 17458
Product name: Reveromycin A
Purity: ≥99%
Packaging: 1mg
Price: $704
Updated: 2024/03/01

TRC

Product number: R279910
Product name: Reveromycin A
Packaging: 250μg
Price: $305
Updated: 2021/12/16

Usbiological

Product number: 464650
Product name: Reveromycin A
Packaging: 100μg
Price: $453
Updated: 2021/12/16

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REVEROMYCIN A Chemical Properties,Usage,Production

Uses

Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of EGF. Reveromycin A is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behaviour against human cell lines KB and K562, as well as potent antifungal activity. More recently it has been shown to induce apoptosis in osteoclasts thus inhibiting bone resorption.

Uses

Reveromycin A is a spiroketal antibiotic inhibitor of EGF mitogenic activity. Inhibits the signal transduction of the epidermal growth factor. May be used

in vivo

Reveromycin A (20 mg/kg; twice daily; i.v.; for 3 days) significantly decreases numbers of OCs without affecting numbers of osteoblasts in normal 4-week-old male Sprague-Dawley rats^[2].

REVEROMYCIN A Preparation Products And Raw materials

Raw materials

Preparation Products

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REVEROMYCIN A Suppliers

China 49 India 1 Switzerland 1 United Kingdom 4 United States 11 Global 66

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134615-37-5, REVEROMYCIN ARelated Search:

L-MIMOSINE VERRUCULOGEN Tangeretin Vinblastine sulfate S-Trityl-L-cysteine Morin hydrate MALVIDIN CHLORIDE TRYPROSTATIN A (E,E)-2,4-Dodecadienal FEMA 3766 1,1-DI(2-METHYLBUTOXY)ETHANE REVEROMYCIN A ACETIC ACID 2-METHYL-4-PENTEN-2-YL ESTER REVEROMYCIN D REVEROMYCIN C REVEROMYCIN B (-)-Reveromycin B, Synthetic (-)-REVEROMYCIN B

REVEROMYCIN A

ZESGNAJSBDILTB-OXVOKJAASA-N

Butanedioic acid, 1-[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrien-1-yl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadien-1-yl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] ester

134615-37-5

C36H52O11

BioChemical

Antibiotics

Antibiotics A to Z

Antibiotics N-S

Epidermal Growth Factor Receptor (EGFR)Antibiotics

Interferes with Protein Synthesis

Antibiotics

Antibiotics A to

Antibiotics by Application

Antibiotics N-SAntibiotics

AntifungalAntibiotics

Mechanism of Action

Receptor Tyrosine Kinase Inhibitors

Spectrum of Activity

Antineoplastic and Immunosuppressive AntibioticsReceptor Tyrosine Kinase Biology