ChemicalBook > CAS DataBase List > (R)-(+)-1-(4-PYRIDYL)ETHANOL

(R)-(+)-1-(4-PYRIDYL)ETHANOL

Reaction

Product Name: (R)-(+)-1-(4-PYRIDYL)ETHANOL
CAS No.: 27854-88-2
Chemical Name: (R)-(+)-1-(4-PYRIDYL)ETHANOL
Synonyms: (1R)-1-(4-Pyridyl)ethanol;(R)-1-(pyridin-4-yl)ethanol;(R)-(+)-1-(4-PYRIDYL)ETHANOL;4-[(R)-1-Hydroxyethyl]pyridine;(R)-1-(pyridin-4-yl)ethan-1-ol;(1R)-1-(pyridin-4-yl)ethan-1-ol;(R)-4-(1-HYDROXYETHYL) PYRIDINE;(R)-α-Methylpyridine-4-methanol;(aR)-a-Methyl-4-PyridineMethanol;(αR)-α-Methylpyridine-4-methanol
CBNumber: CB4444367
Molecular Formula: C7H9NO
Formula Weight: 123.15
MOL File: 27854-88-2.mol

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(R)-(+)-1-(4-PYRIDYL)ETHANOL Property

Melting point:: 67-69 °C(lit.)
Boiling point:: 239.7±15.0 °C(Predicted)
Density: 1.082±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: soluble in Methanol
pka: 13.52±0.20(Predicted)
form: Crystalline Powder or Needles
color: White
optical activity: [α]20/D +55°, c = 1 in chloroform
BRN: 4306037
InChIKey: HVOAMIOKNARIMR-ZCFIWIBFSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
F: 3-10
HS Code: 29333999

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 448532
Product name: (R)-(+)-α-Methyl-4-pyridinemethanol
Purity: 99%
Packaging: 1g
Price: $160
Updated: 2023/01/07

TCI Chemical

Product number: H1733
Product name: (R)-4-(1-Hydroxyethyl)pyridine
Packaging: 1G
Price: $103
Updated: 2025/07/31

TCI Chemical

Product number: H1733
Product name: (R)-4-(1-Hydroxyethyl)pyridine
Packaging: 5G
Price: $355
Updated: 2025/07/31

Strem Chemicals

Product number: 07-1160
Product name: (R)-(+)-α-Methyl-4-pyridinemethanol, min. 98%
Packaging: 50mg
Price: $70
Updated: 2024/03/01

Strem Chemicals

Product number: 07-1160
Product name: (R)-(+)-α-Methyl-4-pyridinemethanol, min. 98%
Packaging: 100mg
Price: $111
Updated: 2024/03/01

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(R)-(+)-1-(4-PYRIDYL)ETHANOL Chemical Properties,Usage,Production

Reaction

Used for the synthesis of chiral 1-(4-pyridinyl)ethylamines
Precursor for intermediates of highly stable chiral (A)6-B Supramolecular Copolymers

Chemical Properties

White needles

Uses

(1R)-1-(4-Pyridyl)ethanol is a building block reagent used in the synthesis of potent GPR119 receptor agonists used in the treatment of diabetes.

Synthesis

1122-54-9

27854-88-2

GENERAL PROCEDURE: BH3-SMe2 (2.0 M toluene solution, 250 μL, 500 μmol) was added to a pre-prepared toluene (1 mL) solution of B-alkoxyoxazaborolidine 8 (7.43 mg, 25.0 μmol) (refer to Procedure 1.2.6 for preparation). The reaction mixture was kept at 50°C for 15 min and then cooled to 20°C. Subsequently, a solution of acetophenone (1a, 60.1 mg, 58.3 μL, 500 μmol) in toluene (1 mL) was slowly added dropwise over 60 min using a syringe pump. After the dropwise addition, the reaction was continued with stirring for 10 min, and then the reaction was quenched by the addition of H2SO4 (1.1 M, 500 μL). The mixture was stirred for another 15 min and then directly separated by column chromatography (silica gel, pentane/Et2O 2:1) to afford the target product (R)-1-(pyridin-4-yl)ethanol ((R)-2a, 58.3 mg, 477 μmol, 95% yield, 97% ee) as a colorless oil.

Purification Methods

Purify it by recrystallisation from pet ether. The m recorded after sublimation was 59.9-60.2o, and 55o after crystallisation from *C6H6/pet ether or pet ether/*C6H6. The (-)-di-O-benzoyl tartrate salt has m 146-148o (from EtOH). [UV, ORD: Harelli & Samori J Chem Soc Perkin Trans 2 1462 1974.] The racemate recrystallises from Et2O with m 74-76o,b 90-94o/1mm. The picrate has m 125-126o (from *C6H6). [Ferles & Attia Collect Czech Chem Commun 38 611 1973, UV, NMR: Nielson et al. J Org Chem 29 2898 1964, Beilstein 21 III/IV 522, 21/2 V 217.]

References

[1] Organic Letters, 2017, vol. 19, # 3, p. 690 - 693
[2] Advanced Synthesis and Catalysis, 2014, vol. 356, # 10, p. 2293 - 2302
[3] Tetrahedron Letters, 2016, vol. 57, # 23, p. 2492 - 2495
[4] Synlett, 1997, vol. 1997, # 3, p. 273 - 274
[5] Synthesis, 2009, # 14, p. 2413 - 2417

(R)-(+)-1-(4-PYRIDYL)ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-(+)-1-(4-PYRIDYL)ETHANOL manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: (R)-(+)-1-(4-Pyridyl)ethanol 27854-88-2
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-18

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-(+)-1-(4-PYRIDYL)ETHANOL 27854-88-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-27

Dideu Industries Group Limited

Product: (R)-(+)-1-(4-PYRIDYL)ETHANOL 27854-88-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-11

27854-88-2, (R)-(+)-1-(4-PYRIDYL)ETHANOLRelated Search:

Diphenyl(4-pyridyl)methanol MESO-ALPHA,BETA-DI(4-PYRIDYL) GLYCOL N-BENZYLCINCHONINIUM CHLORIDE N-(4-Trifloromethybenzyl)cinchoninum bromide CINCHONINE SULFATE Cinchonine QUINIDINE SULFATE (R)-(+)-1-(4-PYRIDYL)ETHANOL QUINIDINE GLUCONATE Quinidine HYDROQUINIDINE HYDROCHLORIDE Quinidine sulfate dihydrate CINCHONINE HYDROCHLORIDE HYDROQUINIDINE HYDROQUINIDINE 4-CHLOROBENZOATE (S)-(-)-1-(4-PYRIDYL)ETHANOL (1S)-1-(3-Pyridyl)ethanol,(S)-1-(3-PYRIDYL)ETHANOL 1-METHYL-1-(4-PYRIDYL)ETHANOL

4-[(R)-1-Hydroxyethyl]pyridine

(R)-4-(1-Hydroxyethyl)pyridine,99+%,(99+% ee)

(R)-4-(1-Hydroxyethyl)pyridine(R)-(+)-1-(4-Pyridyl)ethanol

(R)-1-(pyridin-4-yl)ethanol

(1R)-1-(pyridin-4-yl)ethan-1-ol

4-PyridineMethanol, α-Methyl-, (R)-

(aR)-a-Methyl-4-PyridineMethanol

(R)-(+)-alpha-Methyl-4-pyridinemethanol 99%

(R)-1-(pyridin-4-yl)ethan-1-ol

(αR)-α-Methyl-4-pyridinemethanol,99%e.e.

(R)-(+)-1-(4-PYRIDYL)ETHANOL

(R)-(+)-ALPHA-METHYL-4-PYRIDINEMETHANOL

(R)-4-(1-HYDROXYETHYL) PYRIDINE

(R)-(+)-ALPHA-METHYL-4-PYRIDINEMETHANOL, 99% (98% EE/GLC)

(R)-4-(1-Hydroxyethyl)pyridine, (99+% ee), 99+%

(r)-(+)-α-methyl-4-pyridinemethanol

(R)-4-(1-Hydroxyethyl)pyridine, (99+% ee)

(1R)-1-(4-Pyridyl)ethanol

(R)-α-Methylpyridine-4-methanol

(αR)-α-Methylpyridine-4-methanol

(R)-(+)-Α-METHYL-4-PYRIDINEMETHANOL,MIN.98%

(R)-(+)-α-Methyl-4-pyridinemethanol, min. 98%

-Methyl-4-pyridinemethanol, min. 98%

(R)-1-(pyridin-4-yl)ethan-1-ol27854-88-2

4-Pyridinemethanol, α-methyl-, (αR)-

(R)-(+)-1-(4-PYRIDYL)ETHANOL ISO 9001：2015 REACH

2-Thiazolamine,5-bromo-,hydrobromide(1:3)

1-Naphthalenecarbonitrile,9-methyl-

2-Amino-4-(4-fluorbenzylamino)-5-ethoxycarbonylaminobenzene

(αR)-α-methyl-4-Pyridinemethanol

(<i>R</i>)-(+)-α-Methyl-4-pyridinemethanol

(R)-(+)-α-Methyl-4-pyridinemethanol, CAS 27854-88-2

27854-88-2

Chiral Resolution Reagents

Chiral Resolving Reagents

Asymmetric Synthesis

Alcohols, Hydroxy Esters and Derivatives

Chiral Compounds