ChemicalBook > CAS DataBase List > 4'-Methylthioacetophenone

4'-Methylthioacetophenone

Product Name
4'-Methylthioacetophenone
CAS No.
1778-09-2
Chemical Name
4'-Methylthioacetophenone
Synonyms
Ethanone, 1-[4-(methylthio)phenyl]-;4-(METHYLTHIO)ACETOPHENONE;4-(Methyl thio);p-Acetylthioanisole;4'-Methylthioacetoph;Glycerol Impurity 24;4-(ACETYL)THIOANISOLE;Etoricoxib Impurity 61;4-THIOMETHYLACETOPHENONE;4'-Methylthioacetophenone
CBNumber
CB4454274
Molecular Formula
C9H10OS
Formula Weight
166.24
MOL File
1778-09-2.mol
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4'-Methylthioacetophenone Property

Melting point:
80-82 °C(lit.)
Boiling point:
135 °C
Density 
1.1369 (rough estimate)
refractive index 
1.5600 (estimate)
Flash point:
135°C/1mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform, Methanol
form 
Solid
color 
White to Off-White
BRN 
1860517
InChI
InChI=1S/C9H10OS/c1-7(10)8-3-5-9(11-2)6-4-8/h3-6H,1-2H3
InChIKey
JECUZQLBQKNEMW-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(SC)C=C1)C
CAS DataBase Reference
1778-09-2(CAS DataBase Reference)
NIST Chemistry Reference
4-CH3S-C6H4-COCH3(1778-09-2)
EPA Substance Registry System
4'-(Methylmercapto)acetophenone (1778-09-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29309099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
396583
Product name
4′-(Methylthio)acetophenone
Purity
97%
Packaging
1g
Price
$28.9
Updated
2024/03/01
TCI Chemical
Product number
M1672
Product name
4'-(Methylthio)acetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$71
Updated
2024/03/01
TCI Chemical
Product number
M1672
Product name
4'-(Methylthio)acetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$207
Updated
2024/03/01
Alfa Aesar
Product number
L18074
Product name
4'-(Methylthio)acetophenone, 99%
Packaging
5g
Price
$88.65
Updated
2024/03/01
Alfa Aesar
Product number
L18074
Product name
4'-(Methylthio)acetophenone, 99%
Packaging
25g
Price
$323.65
Updated
2024/03/01
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4'-Methylthioacetophenone Chemical Properties,Usage,Production

Chemical Properties

White to light yellow crystal powde

Uses

4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.

Synthesis Reference(s)

Journal of the American Chemical Society, 73, p. 2857, 1951 DOI: 10.1021/ja01150a127
The Journal of Organic Chemistry, 56, p. 5955, 1991 DOI: 10.1021/jo00020a048

General Description

4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone, p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.

4'-Methylthioacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Methylthioacetophenone Suppliers

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View Lastest Price from 4'-Methylthioacetophenone manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
4"-Methylthioacetophenone 1778-09-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4'-Methylthioacetophenone 1778-09-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2018-08-20

1778-09-2, 4'-MethylthioacetophenoneRelated Search:

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  • Ethanone, 1-[4-(methylthio)phenyl]-
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  • 4'-(Methylthio)acetophenone,97%
  • 4'-Methylthioacetoph
  • 1-[4-(Methylsulfanyl)phenyl]ethan-1-one
  • 1-[4-(Methylsulphanyl)phenyl]ethan-1-one, 4-Acetylthioanisole
  • 1-[4-(METHYLSULFANYL)PHENYL]ETHANONE
  • 1-[4-(methylthio)phenyl]ethan-1-one
  • 1-[4-(METHYLTHIO)PHENYL]ETHANONE
  • 4-METHYLMERCAPTOACETOPHENONE
  • 4'-(METHYLTHIO)ACETOPHENONE
  • 4-(METHYLTHIO)ACETOPHENONE
  • P-(METHYLTHIO)ACETOPHENONE
  • 4-(ACETYL)THIOANISOLE
  • 4'-(Methylthio)acetophenone&gt
  • Etoricoxib Impurity 61
  • 4 ′- (meththyl) phenylacetone
  • 4'-Methylthioacetophenone
  • Glycerol Impurity 24
  • 1778-09-2
  • C9H10OS
  • CH3SC6H4COCH3
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