Doxifluridine

Product Name: Doxifluridine
CAS No.: 3094-09-5
Chemical Name: Doxifluridine
Synonyms: flutron;5'-DFUR;5'DFURD;furtulon;AMC 0101;5-F-5‘-dU;RO-21-9738;5-cl-5'-dU;Doxifluidine;DOXIFLURIDINE
CBNumber: CB4461786
Molecular Formula: C9H11FN2O5
Formula Weight: 246.19
MOL File: 3094-09-5.mol

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Doxifluridine Property

Melting point:: 188-192 °C(lit.)
alpha: D25 +18.4° (c = 0.419 in water)
Density: 1.3751 (estimate)
refractive index: 20 ° (C=1, H2O)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 7.4(at 25℃)
color: White
Merck: 14,3437
CAS DataBase Reference: 3094-09-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-24/25
WGK Germany: 2
RTECS: YU7526000
Hazard Note: Irritant
HazardClass: IRRITANT, IRRITANT-HARMFUL
HS Code: 29349990
Toxicity: LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F8791
Product name: 5-Fluoro-5′-deoxyuridine
Packaging: 25MG
Price: $86.6
Updated: 2023/06/20

Sigma-Aldrich

Product number: Y0001644
Product name: Capecitabine impurity B
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001644
Price: $218
Updated: 2023/06/20

Sigma-Aldrich

Product number: F8791
Product name: 5-Fluoro-5′-deoxyuridine
Packaging: 100MG
Price: $267
Updated: 2023/06/20

Sigma-Aldrich

Product number: F8791
Product name: 5-Fluoro-5′-deoxyuridine
Packaging: 250MG
Price: $466
Updated: 2023/06/20

Sigma-Aldrich

Product number: PHR2850
Product name: 5′-deoxy-5-fluorouridine
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $452
Updated: 2022/05/15

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Doxifluridine Chemical Properties,Usage,Production

Description

Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.

Chemical Properties

White Solid

Originator

Hoffmann-LaRoche (USA)

Uses

A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity

Uses

An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine

Uses

antineoplastic, pyrimidine antimetabolite

Uses

5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.

Definition

ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.

brand name

Furtulon

Biochem/physiol Actions

Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

Doxifluridine Preparation Products And Raw materials

Raw materials

Palladium carbon fine chemical catalyzer p-Toluenesulfonic acid monohydrate Ethyl acetate Triphenylantimony Iodomethane 2,2-Dimethoxypropane

Preparation Products

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Doxifluridine Suppliers

Americas 1 Canada 1 China 271 China Hong Kong 2 Europe 3 Germany 3 India 7 Italy 1 Japan 4 South Korea 1 Switzerland 1 The Netherlands 1 Ukraine 1 United Kingdom 14 United States 45 Global 356

Apollo Scientific Ltd.

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Tokyo Chemical Industry UK Ltd.

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Whyte Chemicals

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Leancare Ltd.

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ProdList: 6446
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CARBONE SCIENTIFIC CO.,LTD

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Atlantic Research Chemicals Ltd.

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Apin Chemicals Limited (UK)

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MOLEKULA Ltd.

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Mann Associates

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ETA SCIENTIFIC Co.,Ltd

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ProdList: 6090
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UK GREEN SCIENTIFIC CO.,LIMITED

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ProdList: 6098
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Eurolabs Limited

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Apin Chemicals Ltd.

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Sequoia Research Products Ltd.

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ProdList: 3113
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View Lastest Price from Doxifluridine manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 5-Fluoro-5′-deoxyuridine 3094-09-5
Price: US $0.00/g
Min. Order: 1g
Purity: ≥98.0%
Supply Ability: 10kg/month
Release date: 2021-09-28

Shaanxi Dideu Medichem Co. Ltd

Product: Doxifluridine 3094-09-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-05

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Doxifluridine 3094-09-5
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100tons
Release date: 2021-12-06

3094-09-5, DoxifluridineRelated Search:

5-Fluorouridine Chenodeoxycholic acid 1-beta-D-Arabinofuranosyluracil Ursodeoxycholic acid 5-Fluorouracil DL-PHENYLEPHRINE HYDROCHLORIDE Trifluridine Floxuridine 3'-O-(5'-Deoxy-α-D-ribofuranosyl) Capecitabine 5'-Deoxy-5-fluorocytidine 2'-O-(5'-Deoxy-β-D-ribofuranosyl) Capecitabine 5'-deoxy-5-fluore-N-[(pentoyloxy)carbonyl]cytidine 2',3'-diacetate CAPECITABINE related substance USP 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine alpha-Capecitabine 2',3'-Di-O-acetyl-5'-deoxy-5-fuluro-D-cytidine 5'-Deoxy-5-fluoro-N4-(isopentyloxycarbonyl)cytidine uridine diphosphate glucose {= UDP-glucose}

5’-deoxy-5-fluoro-uridin

Doxifluridine/5-Fluoro-5′-deoxyuridine

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-oxolan-2-yl]-5-fluoro-pyrimidine-2,4-dione

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-tetrahydrofuran-2-yl]-5-fluoro-pyrimidine-2,4-quinone

Capecitabine Related Compound B (20 mg) (5'-deoxy-5-fluorouridine)

5μdFUrd, Doxifluridine

5μdFUrd, 5-Fluoro-5μ-deoxyuridine

5’-Deoxy-5-fluomuridine

2,4(1H,3H)-Pyrimidinedione, 1-(5-deoxy-b-D-ribofuranosyl)-5-fluoro-

5Urd, 5-Fluoro-5deoxyuridine

URIDINE,5''-DEOXY-5-FLUORO

1-[(2s,3s,4r,5s)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl]-5-fluoropyrimidine-2,4(1h,3h)-dione

flutron

furtulon

Doxifluridine 3094-9-5

1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil

5’dUrd, 5-Fluoro-5’-deoxyuridine, 5’-DFUR, Doxifluridine

5'-dFUrd Doxifluridine 1-(5-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil

Doxifluridine(Ro 21-9738)

CAPECITABINE related substance USP B

Capecitabine Impurity 16（Capecitabine EP Impurity B）

1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyl-2-oxolanyl]-5-fluoropyrimidine-2,4-dione

RO-21-9738

(+)-5-FLUORO-5'-DEOXYURIDINE

5-FLUORO-5'-DEOXYURIDINE

5'-DEOXY-5-FLUOROURIDINE

5'-DEOXYFLUOROURIDINE

5'-DFUR

5'DFURD

DOXIFLURIDINE

MURINE RECOMBINANT

Doxifluridine (furtulon)

DOXIFLUIRDINE

5'-Deoxy-fluorouridine(DFUR)/Doxifluridine

(+)-5-FLUORO-5'-DEOXYURIDINE 97%

5-FLURO-5’-DEOXYURIDINE

5Deoxy-5-fluorouridine, 5DFUR, 5dFUrd, Ro-21-9738

Doxifluidine

DOXIFLURIDINE(SUBJECTTOPATENTFREE)

(+)-5-Fluoro-5'-deoxyuridine98%

5-Fluorodesoxyuridine

Uridine, 5'-deoxy-5-fluoro- (8CI, 9CI)

5-FLUORO-5''-DEOXYURIDINE / DOXIFLURIDINE / 5''-DEOXY-FLUOROURIDINE

(+)-Doxifluridine, (+)-1-(beta-D-5'-Deoxyribofuranosyl)-5-fluorouracil

5-F-5‘-dU

5'-DFUR-13C5 (5'-Deoxy-5-fluorouridine, Doxifluridine-13C5)

AMC 0101

5-cl-5'-dU

Doxifluridine, >=98.5%

Capecitabine USP RC B

Doxifluridine Doxifluridine

Capecitabine Impurity B

5'-Deoxy-5-fluorouridine&gt

Capecitabine EP Impurity B (5'-DFUR, Doxifluridine)

5’-deoxy-5-fluorouridine, Doxifluridine 5'-DFUR

Doxifluridine USP/EP/BP

Capecitabine EP Impurity B/ Capecitabine Related Compund B (Doxifluridine/ Deoxy-5-fluorouridine)