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Camostat

Product Name
Camostat
CAS No.
59721-28-7
Chemical Name
Camostat
Synonyms
FOY 305;CAMOSTAT;Canostat;Camostatum;Ccris 7219;FOY-305：Foipan;Unii-0fd207wkdu;Camostat free base;Camostat formate salt;Camostatum [inn-latin]
CBNumber
CB4462187
Molecular Formula
C20H22N4O5
Formula Weight
398.41
MOL File
59721-28-7.mol
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Camostat Property

Boiling point:
590.5±60.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
pka
10.17±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0010925
Product name
CAMOSTAT
Purity
95.00%
Packaging
5MG
Price
$502.48
Updated
2021/12/16
AHH
Product number
MT-48918
Product name
Camostat
Purity
98%
Packaging
0.5g
Price
$910
Updated
2021/12/16
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Camostat Chemical Properties,Usage,Production

Chemical Properties

Camostat mesylate: C20H22N4O5?CH3SO3H. [59721-29-8]. Crystallized from methanol-ether, melting point 150-155°C. Soluble in water. Acute toxicity LD50 in mice and rats (mg/kg): 4040-4500, 4392-4720 oral.

Uses

Camostat is an orally active trypsin inhibitor. Camostat can reduce pancreatic fibrosis induced by repeated administration of superoxide dismutase inhibitors in rats, and decrease the proliferation and activation of pancreatic stellate cells (PSCs)[1].

Definition

ChEBI: Camostat is a benzoate ester resulting from the formal condensation of the carboxy group of 4-guanidinobenzoic acid with the hydroxy group of 2-(dimethylamino)-2-oxoethyl (4-hydroxyphenyl)acetate. It is a potent inhibitor of the human transmembrane protease serine 2 (TMPRSS2) and its mesylate salt is currently under investigation for its effectiveness in COVID-19 patients. It has a role as an anticoronaviral agent, a serine protease inhibitor, an antifibrinolytic drug, an anti-inflammatory agent, an antiviral agent, an antihypertensive agent and an antineoplastic agent. It is a tertiary carboxamide, a carboxylic ester, a diester, a member of guanidines and a benzoate ester. It is functionally related to a 4-guanidinobenzoic acid. It is a conjugate base of a camostat(1+).

References

[1] Emori Y, et al. Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats. J Gastroenterol Hepatol. 2005 Jun;20(6):895-9. DOI:10.1111/j.1440-1746.2005.03826.x

Camostat Preparation Products And Raw materials

Raw materials

Formyl chloride Triethylamine 4-Hydroxyphenylacetic acid 2-BROMOACETAMIDE Methyl bromide

Preparation Products

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Camostat Suppliers

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59721-28-7, CamostatRelated Search:

CAMOSTAT MESYLATE,CAMOSTAT MESILATE 4-Methoxyphenylacetic acid 4-Hydroxyphenylacetic acid Carmofur 3-Dimethylaminopropylamine 2-Hydroxyphenylacetic acid Diethoxydimethylsilane Dimethyldimethoxysilane Carmustine Testosterone phenylacetate Phenylacetic acid 4-ETHOXYPHENYLACETIC ACID ETHYL 4-ETHOXYPHENYLACETATE 4-BENZYLOXYPHENYLACETIC ACID 2-(4-BENZYLOXYPHENYL)ETHANOL ETHYL 4-METHOXYPHENYLACETATE 4-BENZYLOXYPHENYLACETIC ACID METHYL ESTER Camostat

  • CAMOSTAT
  • 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneaxetic acid 2-(dimethylamino)-oxoethyl ester
  • Camostat (base and/or unspecified salts)
  • 2-(Dimethylamino)-2-oxoethyl 4-(4-guanidinobenzoyloxy)phenylacetate
  • Camostat Monomethanesulfonate
  • FOY-305：Foipan
  • N，N-Dimethylcarbamoylmethyl-p(p-guanidinobenzoyloxy)phenylacetate
  • 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester
  • 4-Guanidinobenzoic acid 4-[[[(dimethylcarbamoyl)methoxy]carbonyl]methyl]phenyl ester
  • 4-Guanidinobenzoic acid-4-(dimethylcarbamoylmethoxycarbonylmethyl)phenyl ester
  • p-(p-Guanidinobenzoyloxy)phenylacetic acid=dimethylcarbamoylmethyl ester
  • 59721-29-8 (Monomethanesulfonate)
  • Camostatum
  • Camostatum [inn-latin]
  • Ccris 7219
  • Dimethylcarbamoylmethyl 4-(4-guqnidinobenzoyloxy)phenylacetat
  • Unii-0fd207wkdu
  • 2-{4-[(4-carbaMiMidaMidophenyl)carbonyloxy]phenyl}-3-(diMethylcarbaMoyl)propanoate
  • Benzeneacetic acid, 4-[[4-[(aMinoiMinoMethyl)aMino]benzoyl]oxy]-, 2-(diMethylaMino)-2-oxoethyl ester
  • FOY 305
  • 4-[[4-[(aMinoiMinoMethyl)aMino]benzoyl]oxy]-, 2-(diMethylaMino)- 2-oxoethyl ester, MonoMethanesulfonate
  • 4-(2-(2-(Dimethylamino)-2-oxoethoxy)-2-oxoethyl)phenyl 4-guanidinobenzoate
  • 4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl]4-(diaminomethylideneamino)benzoate
  • Camostat formate salt
  • Camostat free base
  • Canostat
  • 59721-28-7
  • API