2-Chloro-3-(trifluoromethyl)pyridine
- Product Name
- 2-Chloro-3-(trifluoromethyl)pyridine
- CAS No.
- 65753-47-1
- Chemical Name
- 2-Chloro-3-(trifluoromethyl)pyridine
- Synonyms
- 2-Chloro-3-trifuoromethylpyridine;2-Chloro-3-Trifluromethyl Pyridine;2,3-ctf;BUTTPARK 45\10-29;2-Chloro-3-(trifluor;2-Chloro-3-(trifluoromethyl)ptridine;2-CHLORO-3-(TRIFLUOROMETHYL)PYRIDINE;2-chloro-3-(trifluoroMethyl)pyridien;2-chloro-3-triifluoromethyl pyridine;PYRIDINE, 2-CHLORO-3-(TRIFLUOROMETHYL)-
- CBNumber
- CB4466387
- Molecular Formula
- C6H3ClF3N
- Formula Weight
- 181.54
- MOL File
- 65753-47-1.mol
2-Chloro-3-(trifluoromethyl)pyridine Property
- Melting point:
- 36-40 °C(lit.)
- Boiling point:
- 166-168°C
- Density
- 1.416±0.06 g/cm3(Predicted)
- Flash point:
- 180 °F
- storage temp.
- Storage temp. 2-8°C
- solubility
- soluble in Methanol
- pka
- -1.68±0.10(Predicted)
- form
- Crystals
- color
- Semi-transparent
- BRN
- 4179716
- InChI
- InChI=1S/C6H3ClF3N/c7-5-4(6(8,9)10)2-1-3-11-5/h1-3H
- InChIKey
- RXATZPCCMYMPME-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC=C1C(F)(F)F
- CAS DataBase Reference
- 65753-47-1(CAS DataBase Reference)
Safety
- Hazard Codes
- F,T,Xi
- Risk Statements
- 11-25-36/37/38-52/53-48/25-34-24/25
- Safety Statements
- 16-22-36/37/39-45-61-26-23
- RIDADR
- UN 2926 4.1/PG 2
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H372Causes damage to organs through prolonged or repeated exposure
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 469378
- Product name
- 2-Chloro-3-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $46.6
- Updated
- 2023/06/20
- Product number
- 469378
- Product name
- 2-Chloro-3-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $90
- Updated
- 2023/06/20
- Product number
- C1193
- Product name
- 2-Chloro-3-(trifluoromethyl)pyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $60
- Updated
- 2024/03/01
- Product number
- C1193
- Product name
- 2-Chloro-3-(trifluoromethyl)pyridine
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $19
- Updated
- 2021/12/16
- Product number
- C422230
- Product name
- 2-Chloro-3-(trifluoromethyl)pyridine
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
2-Chloro-3-(trifluoromethyl)pyridine Chemical Properties,Usage,Production
Chemical Properties
semi-transparent crystals
Uses
2-Chloro-3-(trifluoromethyl)pyridine may be used in the preparation of 5,5′-bis(trifluoromethyl)-2,2′-bipyridine, via modified Ullmann reaction.
General Description
2-Chloro-3-(trifluoromethyl)pyridine is a trifluoromethyl-substituted pyridine derivative.
Synthesis
22253-72-1
52334-81-3
65753-47-1
In a four-necked flask equipped with a stirrer, thermometer and a drying tube, 32.62 g of 3-trifluoromethylpyridine N-oxide (CAS: 22253-72-1) and 46.0 g of phosphorus trichloride were added. The reaction mixture was stirred at 105-110°C for 2 hours. Subsequently, the temperature was raised to 120-125°C and the reaction was continued for 5 hours. The reaction mixture was analyzed by liquid chromatography and confirmed to contain 0.16% of 3-trifluoromethylpyridine N-oxide, 50.34% of 2-chloro-3-trifluoromethylpyridine and 25.34% of 2-chloro-5-trifluoromethylpyridine. The reaction mixture was heated under reduced pressure (100 mmHg) until an internal temperature of 75°C was reached to remove excess TCPO by distillation. The reaction mixture was slowly added to 163.1 g of ice water at a controlled temperature not exceeding 30°C and stirred for 1 hour. The reaction mixture was extracted with 1,2-dichloroethane, stirred for 30 minutes and partitioned. The organic layer was washed with water to give 132.11 g of a 1,2-dichloroethane solution containing 2-chloro-3-trifluoromethylpyridine. Liquid chromatographic analysis showed that the solution contained 13.17 g of 2-chloro-3-trifluoromethylpyridine.
References
[1] Patent: US2012/259125, 2012, A1. Location in patent: Page/Page column 3
2-Chloro-3-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-3-(trifluoromethyl)pyridine Suppliers
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View Lastest Price from 2-Chloro-3-(trifluoromethyl)pyridine manufacturers
- Product
- 2-Chloro-3-(trifluoromethyl)pyridine 65753-47-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 250KG
- Purity
- Purity: 99%
- Supply Ability
- 1000tons
- Release date
- 2025-07-20
- Product
- 2-Chloro-3-(trifluoromethyl)pyridine 65753-47-1
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 30 tons
- Release date
- 2024-02-28
- Product
- 2-Chloro-3-(trifluoromethyl)pyridine 65753-47-1
- Price
- US $99.00-92.00/kilograms
- Min. Order
- 1kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-02-14