Methyl 4-(chloroformyl)butyrate

Product Name: Methyl 4-(chloroformyl)butyrate
CAS No.: 1501-26-4
Chemical Name: Methyl 4-(chloroformyl)butyrate
Synonyms: Methyl 5-chloro-5-;Methyl 4-(chloroform;METHYL GLUTARYL CHLORIDE;METHYL 5-CHLORO-5-OXOVALERATE;CARBOMETHOXYL BUTYRYL CHLORIDE;METHYL 4-(CHLOROFORMYL)BUTYRATE;METHYL 5-CHLORO-5-OXOPENTANOATE;METHYL 5-CHLORO-5-OXOVALERATE,98%;Methyl 4-(Chlorocarbonyl)butyrate;Methyl 4-(chlorocarbonyl)butanoate
CBNumber: CB4480260
Molecular Formula: C6H9ClO3
Formula Weight: 164.59
MOL File: 1501-26-4.mol

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Methyl 4-(chloroformyl)butyrate Property

Boiling point:: 110 °C/17 mmHg (lit.)
Density: 1.191 g/mL at 25 °C (lit.)
refractive index: n20/D 1.445(lit.)
Flash point:: 180 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Hexane
form: Oil
color: Clear Colourless
Water Solubility: reacts
Sensitive: Moisture Sensitive
BRN: 1762383
CAS DataBase Reference: 1501-26-4(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45-24/25
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
F: 10-21
HazardClass: 8
PackingGroup: II
HS Code: 2918300090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M35355
Product name: Glutaric acid monomethyl ester chloride
Purity: 98%
Packaging: 10g
Price: $107.35
Updated: 2025/07/31

Sigma-Aldrich

Product number: M35355
Product name: Glutaric acid monomethyl ester chloride
Purity: 98%
Packaging: 50g
Price: $269.5
Updated: 2025/07/31

TRC

Product number: M227420
Product name: Methyl4-(Chloroformyl)butyrate
Packaging: 10g
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 139913
Product name: Methyl 5-chloro-5-oxopentanoate
Purity: 95%+
Packaging: 2.500g
Price: $215
Updated: 2021/12/16

Matrix Scientific

Product number: 139913
Product name: Methyl 5-chloro-5-oxopentanoate
Purity: 95%+
Packaging: 5g
Price: $323
Updated: 2021/12/16

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Methyl 4-(chloroformyl)butyrate Chemical Properties,Usage,Production

Chemical Properties

clear colourless to light yellow liquid

Uses

Methyl 4-(Chloroformyl)butyrate is used in the synthesis of Leukotriene B4, a proinflammatory agent produced from leukocytes.

Synthesis

67-56-1

108-55-4

1501-26-4

1. 100 g (0.878 mol) of glutaric anhydride was dissolved in 50 mL of anhydrous methanol and heated to reflux for 1 h. 2. Upon completion of the reaction, unreacted methanol was removed by distillation under reduced pressure. 3. The reaction mixture was cooled to room temperature, and 200 mL of acetochloride was slowly added. 4. The reaction mixture was heated for 6 h., wherein after 2 h of heating the remaining dichloro sulfoxide.5. Finally, the fractions were dried at 96 °C to 98 °C/10 mmHg to give 124.2 g of methyl 4-chlorocarbonylbutyrate as a light yellow liquid in 86.4% yield.

References

[1] Patent: CN103864658, 2016, B. Location in patent: Paragraph 0056; 0057
[2] Tetrahedron Letters, 1984, vol. 25, # 39, p. 4371 - 4374
[3] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, # 6, p. 915 - 923

Methyl 4-(chloroformyl)butyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 4-(chloroformyl)butyrate Suppliers

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View Lastest Price from Methyl 4-(chloroformyl)butyrate manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl 4-(chloroformyl)butyrate 1501-26-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl 4-(chloroformyl)butyrate 1501-26-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl 4-(chloroformyl)butyrate 1501-26-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

1501-26-4, Methyl 4-(chloroformyl)butyrateRelated Search:

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METHYL 4-(CHLOROFORMYL)BUTYRATE 1501-26-4

Methyl 5-chloro-5-

1501-26-4

ClCOCH23CO2CH3

ClCOCH23COOCH3

ACID CHLORIDE

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Carbonyl Compounds

Acid Halides

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Acid Halides

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Carbonyl Compounds

Chemical Synthesis

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Halogen compounds