ChemicalBook > CAS DataBase List > IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE

Product Name: IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
CAS No.: 6188-43-8
Chemical Name: IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE
Synonyms: Minodronic Acid Impurity 30;[1,2-α]PYRIDIN-3-CARBOXALDEHYDE;Imidazo[1,2-a]pyridine-3-carbaldehyde;imidazo[3,2-a]pyridine-3-carbaldehyde;3-imidazo[3,2-a]pyridinecarboxaldehyde;IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE;IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE;Imidazo[1,2-a]pyridine-3-carbaldehyde AldrichCPR;Imidazo[1,2-a]pyridine-3-carboxaldehyde (7CI, 8CI, 9CI, ACI)
CBNumber: CB4483670
Molecular Formula: C8H6N2O
Formula Weight: 146.15
MOL File: 6188-43-8.mol

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IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Property

Melting point:: 127-129 °C
Density: 1.24±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.15±0.50(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: I387593
Product name: Imidazo[1,2-a]pyridine-3-carbaldehyde
Packaging: 500mg
Price: $175
Updated: 2021/12/16

Matrix Scientific

Product number: 040365
Product name: Imidazo[1,2-a]pyridine-3-carbaldehyde
Packaging: 500mg
Price: $252
Updated: 2021/12/16

Apolloscientific

Product number: OR909920
Product name: Imidazo[1,2-a]pyridine-3-carbaldehyde
Purity: 98%
Packaging: 5g
Price: $330
Updated: 2021/12/16

Apolloscientific

Product number: OR909920
Product name: Imidazo[1,2-a]pyridine-3-carbaldehyde
Purity: 98%
Packaging: 10g
Price: $565
Updated: 2021/12/16

Apolloscientific

Product number: OR909920
Product name: Imidazo[1,2-a]pyridine-3-carbaldehyde
Purity: 98%
Packaging: 1g
Price: $115
Updated: 2021/12/16

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IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Chemical Properties,Usage,Production

Synthesis

274-76-0

68-12-2

6188-43-8

Freshly distilled phosphorus trichloride (61 mL, 0.65 mol) was slowly added to N,N-dimethylformamide (120 mL, 1.55 mol) at 2 °C. After controlling the reaction temperature to gradually increase to room temperature, the reaction system was again cooled to 2 °C. Subsequently, a solution of N,N-dimethylformamide (60 mL) of imidazo[1,2-a]pyridine (10 g, 0.085 mol) was added dropwise. The reaction mixture was slowly warmed to 105 °C, followed by further warming to 140 °C. The reaction temperature was stabilized at 120 °C by removing the oil bath. Heating was continued at this temperature for 45 minutes, after which the temperature was reduced to 85 °C and continued for 2.5 hours. Upon completion of the reaction, the mixture was cooled and poured into ice-cooled 5% hydrochloric acid (600 mL) and the pH was adjusted with 20% sodium hydroxide solution to 9. The resulting solution was extracted with dichloromethane (1200 mL) overnight. The organic layer was separated, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was washed with water (5 x 15 mL) and dried again to give 3.49 g of imidazo[1,2-a]pyridine-3-carbaldehyde in 31% yield.

References

[1] Farmaco, Edizione Scientifica, 1981, vol. 36, # 12, p. 994 - 1003
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3454 - 3464
[3] European Journal of Medicinal Chemistry, 2011, vol. 46, # 10, p. 4820 - 4826
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 14, p. 2856 - 2859
[5] Patent: WO2005/66132, 2005, A1. Location in patent: Page/Page column 89-90

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Imidazo[1,2-a]pyridine-3-carbaldehyde 6188-43-8
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Career Henan Chemical Co

Product: IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE 6188-43-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-09

6188-43-8, IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDERelated Search:

IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDINE-3-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID IMIDAZO[1,2-A]PYRIDIN-2-YLMETHANOL ETHYL IMIDAZO[1,2-A]PYRIDINE-7-CARBOXYLATE 98 Dimethyl 4,5-imidazoledicarboxylate Imidazo[1,2-a]pyridine-6-boronic acid Imidazo[1,2-a]pyridin-5-ylamine Imidazo[1,2-a]pyridine-7-carboxylic acid (9CI) Ethyl Imidazo[1,2-a]pyridine-3-carboxylate IMIDAZO[1,5-A]PYRIDINE-1-CARBOXYLIC ACID ETHYL ESTER ETHYL IMIDAZO[1,2-A]PYRAZINE-2-CARBOXYLATE METHYL IMIDAZO[1,2-A]PYRIDINE-6-CARBOXYLATE Imidazo[1,2-a]pyridine-6-boronic acic pinacol ester Imidazo[1,2-a]pyridine-7-boronic acid pinacol ester Methyl imidazo[1,2-a]pyridine-7-carboxylate

imidazo[3,2-a]pyridine-3-carbaldehyde

IMIDAZO[1,2-A]PYRIDINE-3-CARBOXALDEHYDE

IMIDAZO[1,2-A]PYRIDIN-3-CARBOXALDEHYDE

[1,2-α]PYRIDIN-3-CARBOXALDEHYDE

Imidazo[1,2-a]pyridine-3-carbaldehyde

Imidazo[1,2-a]pyridine-3-carbaldehyde AldrichCPR

3-imidazo[3,2-a]pyridinecarboxaldehyde

Imidazo[1,2-a]pyridine-3-carboxaldehyde (7CI, 8CI, 9CI, ACI)

Minodronic Acid Impurity 30

6188-43-8

6168-43-8

blocks

Imidazoles

Pyridines