ChemicalBook > CAS DataBase List > 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
- Product Name
- 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
- CAS No.
- 1646499-97-9
- Chemical Name
- 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
- Synonyms
- ML 382;ML382, 10 mM in DMSO;2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide;2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide;Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-;ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382
- CBNumber
- CB44902689
- Molecular Formula
- C18H20N2O4S
- Formula Weight
- 360.43
- MOL File
- 1646499-97-9.mol
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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Property
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- A solid
- pka
- 8.30±0.20(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Tocris
- Product number
- 5738
- Product name
- ML382
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $149
- Updated
- 2021/12/16
Tocris
- Product number
- 5738
- Product name
- ML382
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $622
- Updated
- 2021/12/16
TRC
- Product number
- M425455
- Product name
- ML382
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
DC Chemicals
- Product number
- DC20900
- Product name
- ML382
- Purity
- >98%
- Packaging
- 250mg
- Price
- $850
- Updated
- 2021/12/16
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2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Chemical Properties,Usage,Production
Uses
ML 382 acts as a potent and selective allosteric modulator of MrgX1, used in the stufy to improve the potency and efficacy of anti-chronic pain medicaments.
Biological Activity
ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22.
storage
Store at RT
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
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