ChemicalBook > CAS DataBase List > 1,3-Thiazole-2-carbaldehyde

1,3-Thiazole-2-carbaldehyde

Product Name: 1,3-Thiazole-2-carbaldehyde
CAS No.: 10200-59-6
Chemical Name: 1,3-Thiazole-2-carbaldehyde
Synonyms: THIAZOLE-2-CARBALDEHYDE;20:5n3);EOS-61959;2-FORMYLTHIAZOLE;2-Formylthiazole>2-Formyl-1,3-thiazole;2-Thiazolecarbaldehyde;thiazol-2-carbaldehyde;eicosapentaenoate (EPA;2-THIAZOLECARBOXALDEHYDE
CBNumber: CB4493103
Molecular Formula: C4H3NOS
Formula Weight: 113.14
MOL File: 10200-59-6.mol

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1,3-Thiazole-2-carbaldehyde Property

Boiling point:: 61-63 °C/15 mmHg (lit.)
Density: 1.288 g/mL at 25 °C (lit.)
refractive index: n20/D 1.574(lit.)
Flash point:: 154 °F
storage temp.: 2-8°C
form: Liquid
pka: 0.44±0.10(Predicted)
color: Colorless to pale yellow
Water Solubility: soluble
InChI: InChI=1S/C4H3NOS/c6-3-4-5-1-2-7-4/h1-3H
InChIKey: ZGTFNNUASMWGTM-UHFFFAOYSA-N
SMILES: S1C=CN=C1C=O
LogP: 0.602 (est)
CAS DataBase Reference: 10200-59-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-22
Safety Statements: 36/37/39-26-23-36
WGK Germany: 3
Hazard Note: Harmful
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 422460
Product name: 2-Thiazolecarboxaldehyde
Purity: 97%
Packaging: 1g
Price: $81.79
Updated: 2025/07/31

TCI Chemical

Product number: F0303
Product name: 2-Formylthiazole
Purity: >97.0%(GC)
Packaging: 1g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: F0303
Product name: 2-Formylthiazole
Purity: >97.0%(GC)
Packaging: 5g
Price: $127
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK613181
Product name: 2-Thiazolecarboxaldehyde
Purity: 97%
Packaging: 1g
Price: $98
Updated: 2021/12/16

Matrix Scientific

Product number: 069072
Product name: Thiazole-2-carboxaldehyde
Purity: 98%
Packaging: 25g
Price: $119
Updated: 2021/12/16

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1,3-Thiazole-2-carbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

2-Thiazolecarboxaldehyde is a useful building block for taxane analogs.

Synthesis Reference(s)

Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146

General Description

2-Thiazolecarboxaldehyde is a thiazole aldehyde derivative. It undergoes Baylis–Hillman reaction with methyl acrylate catalyzed by DABCO (1,4-diazabicyclo[2.2.2]octane). The reaction mechanism has been studied by electrospray ionization mass spectrometry (ESI-MS).

Synthesis

3034-53-5

68-12-2

10200-59-6

General procedure for the synthesis of 2-formylthiazole from 2-bromothiazole and N,N-dimethylformamide: An ether (43 mL) solution of 2-bromothiazole (10.00 g, 60.96 mmol) was added dropwise to a cooled solvate over a period of 1 hr at -78°C. Subsequently, 1.6 M butyl lithium (46 mL, 73.5 mmol) in hexane was added. The resulting mixture was stirred at -70 °C for 20 min, and then N,N-dimethylformamide (7.50 mL, 97.5 mmol) was added over 1 h while keeping the temperature below -65 °C. The reaction was carried out at -65 °C. The reaction mixture was warmed to -40°C over 1 hr and stirring was continued at this temperature for 1 hr. The reaction mixture was slowly warmed to 0 °C and quenched with 4 M aqueous hydrochloric acid. The organic and aqueous layers were separated. The organic layer was washed with 4M aqueous hydrochloric acid solution and discarded. The combined aqueous layers were neutralized with potassium carbonate and extracted with ether (3 times). The combined organic extracts were dried over magnesium sulfate, filtered, and the solvent was removed in vacuum to give 2-formylthiazole (6.88 g, 99% yield) as a brown oil, which did not require further purification.

References

[1] Patent: WO2006/92268, 2006, A1. Location in patent: Page/Page column 22
[2] Journal of Organic Chemistry, 1995, vol. 60, # 15, p. 4749 - 4754
[3] Patent: US5512575, 1996, A
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, vol. 62, # 12, p. 1525 - 1529
[5] Patent: WO2018/108125, 2018, A1. Location in patent: Paragraph 00539

1,3-Thiazole-2-carbaldehyde Preparation Products And Raw materials

Raw materials

2-Aminothiazole n-Butyllithium

Preparation Products

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1,3-Thiazole-2-carbaldehyde Suppliers

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View Lastest Price from 1,3-Thiazole-2-carbaldehyde manufacturers

Sach biotech Co.,Ltd

Product: 1,3-Thiazole-2-carbaldehyde 10200-59-6
Price: US $768.00-15000.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10mt
Release date: 2025-06-06

Hebei Chuanghai Biotechnology Co,.LTD

Product: 1,3-Thiazole-2-carbaldehyde 10200-59-6
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-19

JINING XINHE CHEMICAL CO., LTD

Product: 1,3-Thiazole-2-carbaldehyde 10200-59-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10ton
Release date: 2024-07-23

10200-59-6, 1,3-Thiazole-2-carbaldehydeRelated Search:

2-Acetylthiazole 2-(Trimethylsilyl)thiazole 2-Thiazolesulfonamide(9CI) Ethyl thiazole-2-carboxylate THIAZOLE-2-CARBOTHIOIC ACID AMIDE THIAZOLE-2-CARBOXYLIC ACID HYDRAZIDE ETHYL 1,3-BENZOTHIAZOLE-2-CARBOXYLATE 6-METHOXYBENZOTHIAZOLE-2-CARBOXAMIDE Benzothiazole-2-carboxaldehyde 4-Phenylthiazole-2-carboxylic acid (4-FORMYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER 4-CHLORO-2-PIPERIDIN-1-YL-1,3-THIAZOLE-5-CARBALDEHYDE,4-CHLORO-2-PIPERIDIN-1-YL-THIAZOLE-5-CARBALDEHYDE 2-Bromo-4-fomylthiazole 2-Amino-5-formylthiazole 4-METHYL-THIAZOLE-5-CARBALDEHYDE 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE-5-CARBALDEHYDE 4,5-THIAZOLEDICARBOXALDEHYDE 4-BROMO-2-FORMYLTHIAZOLE

2-THIAZOLECARBOXALDEHYDE

2-THIAZOLECARBOXYALDEHYDE

THIAZOLE-2-CARBALDEHYDE

THIAZOLE-2-CARBOXALDEHYDE

1,3-Thiazole-2-carboxaldehyde

2-ThiazoleCarboxaldehyde(=2-FormylThiazole)

2-FORMYLTHIAZOLE

1,3-THIAZOLE-2-CARBALDEHYDE

1,3-Thiazole-2-carboxaldehyde 95%

2-THIOZOLE CARBOXALDEHYDE

2-Thiazolecarboxaldehyde ,97%

2-Thiazolecarbaldehyde

1,3-Thiazole-2-Carbaldehyd

2-Thiazolecarboxaldehyde,98%

1,3-Thiazole-2-carboxaldehyde 95+%

2-Formyl-1,3-thiazole

thiazol-2-carbaldehyde

EOS-61959

2-Thiazolecarboxaldehyde 97%

2-Formylthiazole&gt

20:5n3)

eicosapentaenoate (EPA

1,3-Thiazole-2-carbaldehyde ISO 9001：2015 REACH

2-Thiazolecarboxaldehyde (6CI, 7CI, 8CI, 9CI, ACI)

10200-59-6

C4H3NOS

Heterocyclic Building Blocks

Thiazoles

Building Blocks

Thiazole

Thiazoles, Isothiazoles & Benzothiazoles

Boronic Acid

Heterocyclic Compounds

Building Blocks

Heterocyclic Building Blocks

Aldehydes

Thiazoles, Isothiazoles &Benzothiazoles

API

Thiazoles

Building Blocks