1,3-Thiazole-2-carbaldehyde
- Product Name
- 1,3-Thiazole-2-carbaldehyde
- CAS No.
- 10200-59-6
- Chemical Name
- 1,3-Thiazole-2-carbaldehyde
- Synonyms
- THIAZOLE-2-CARBALDEHYDE;20:5n3);EOS-61959;2-FORMYLTHIAZOLE;2-Formylthiazole>2-Formyl-1,3-thiazole;2-Thiazolecarbaldehyde;thiazol-2-carbaldehyde;eicosapentaenoate (EPA;2-THIAZOLECARBOXALDEHYDE
- CBNumber
- CB4493103
- Molecular Formula
- C4H3NOS
- Formula Weight
- 113.14
- MOL File
- 10200-59-6.mol
1,3-Thiazole-2-carbaldehyde Property
- Boiling point:
- 61-63 °C/15 mmHg (lit.)
- Density
- 1.288 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.574(lit.)
- Flash point:
- 154 °F
- storage temp.
- 2-8°C
- form
- Liquid
- pka
- 0.44±0.10(Predicted)
- color
- Colorless to pale yellow
- Water Solubility
- soluble
- InChI
- InChI=1S/C4H3NOS/c6-3-4-5-1-2-7-4/h1-3H
- InChIKey
- ZGTFNNUASMWGTM-UHFFFAOYSA-N
- SMILES
- S1C=CN=C1C=O
- LogP
- 0.602 (est)
- CAS DataBase Reference
- 10200-59-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 36/37/39-26-23-36
- WGK Germany
- 3
- Hazard Note
- Harmful
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 422460
- Product name
- 2-Thiazolecarboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $81.79
- Updated
- 2025/07/31
- Product number
- F0303
- Product name
- 2-Formylthiazole
- Purity
- >97.0%(GC)
- Packaging
- 1g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- F0303
- Product name
- 2-Formylthiazole
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $127
- Updated
- 2025/07/31
- Product number
- 069072
- Product name
- Thiazole-2-carboxaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- D363
- Product name
- 2-Thiazolecarboxaldehyde
- Packaging
- 1g
- Price
- $14
- Updated
- 2021/12/16
1,3-Thiazole-2-carbaldehyde Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liqui
Uses
2-Thiazolecarboxaldehyde is a useful building block for taxane analogs.
Synthesis Reference(s)
Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146
General Description
2-Thiazolecarboxaldehyde is a thiazole aldehyde derivative. It undergoes Baylis–Hillman reaction with methyl acrylate catalyzed by DABCO (1,4-diazabicyclo[2.2.2]octane). The reaction mechanism has been studied by electrospray ionization mass spectrometry (ESI-MS).
Synthesis
3034-53-5
68-12-2
10200-59-6
General procedure for the synthesis of 2-formylthiazole from 2-bromothiazole and N,N-dimethylformamide: An ether (43 mL) solution of 2-bromothiazole (10.00 g, 60.96 mmol) was added dropwise to a cooled solvate over a period of 1 hr at -78°C. Subsequently, 1.6 M butyl lithium (46 mL, 73.5 mmol) in hexane was added. The resulting mixture was stirred at -70 °C for 20 min, and then N,N-dimethylformamide (7.50 mL, 97.5 mmol) was added over 1 h while keeping the temperature below -65 °C. The reaction was carried out at -65 °C. The reaction mixture was warmed to -40°C over 1 hr and stirring was continued at this temperature for 1 hr. The reaction mixture was slowly warmed to 0 °C and quenched with 4 M aqueous hydrochloric acid. The organic and aqueous layers were separated. The organic layer was washed with 4M aqueous hydrochloric acid solution and discarded. The combined aqueous layers were neutralized with potassium carbonate and extracted with ether (3 times). The combined organic extracts were dried over magnesium sulfate, filtered, and the solvent was removed in vacuum to give 2-formylthiazole (6.88 g, 99% yield) as a brown oil, which did not require further purification.
References
[1] Patent: WO2006/92268, 2006, A1. Location in patent: Page/Page column 22
[2] Journal of Organic Chemistry, 1995, vol. 60, # 15, p. 4749 - 4754
[3] Patent: US5512575, 1996, A
[4] Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2007, vol. 62, # 12, p. 1525 - 1529
[5] Patent: WO2018/108125, 2018, A1. Location in patent: Paragraph 00539
1,3-Thiazole-2-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
1,3-Thiazole-2-carbaldehyde Suppliers
- Tel
- --
- Fax
- --
- info@argus.it
- Country
- Italy
- ProdList
- 87
- Advantage
- 66
View Lastest Price from 1,3-Thiazole-2-carbaldehyde manufacturers
- Product
- 1,3-Thiazole-2-carbaldehyde 10200-59-6
- Price
- US $768.00-15000.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10mt
- Release date
- 2025-06-06
- Product
- 1,3-Thiazole-2-carbaldehyde 10200-59-6
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-19
- Product
- 1,3-Thiazole-2-carbaldehyde 10200-59-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10ton
- Release date
- 2024-07-23