BETAMETHASONE BENZOATE (200 MG) Property

Melting point:

225-228°

alpha 

D24 +63.5° (dioxane)

Boiling point:

641.0±55.0 °C(Predicted)

Density 

1.1732 (estimate)

storage temp. 

Store at -20°C

solubility 

Soluble in DMSO

pka

12.93±0.70(Predicted)

Safety

RIDADR 

UN 2811 6.1 / PGII

WGK Germany 

1

HS Code 

2937220000

Toxicity

LD50 scu-rat: 194 mg/kg TXAPA9 8,250,66

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

BETAMETHASONE BENZOATE (200 MG) Chemical Properties,Usage,Production

Originator

Benisone,Warner Lambert,US,1973

Uses

BETAMETHASONE BENZOATE (200 MG) is an analog of Betamethasone (B327000), a glucocorticoid used as an anti-inflammatory agent.

Definition

ChEBI: Betamethasone benzoate is a 21-hydroxy steroid.

Manufacturing Process

A mixture of 50 g of betamethasone, 50 cc of dimethylformamide, 50 cc of methyl orthobenzoate and 1.5 g of p-toluenesulfonic acid is heated for 24 hours on oil bath at 105°C while a slow stream of nitrogen is passed through the mixture and the methanol produced as a byproduct of the reaction is distilled off. After addition of 2 cc of pyridine to neutralize the acid catalyst the solvent and the excess of methyl orthobenzoate are almost completely eliminated under vacuum at moderate temperature. The residue is chromatographed on a column of 1,500 g of neutral aluminum oxide. By elution with ether-petroleum ether 30 g of a crystalline mixture are obtained consisting of the epimeric mixture of 17α,21-methyl orthobenzoates. This mixture is dissolved without further purification, in 600 cc of methanol and 240 cc of methanol and 240 cc of aqueous 2N oxalic acid are added to the solution. The reaction mixture is heated at 40°-50°C on water bath, then concentrated under vacuum, The residue, crystallized from acetone-ether, gives betamethasone 17-benzoate, MP 225°-231°C.

brand name

Uticort (Parke- Davis).

Therapeutic Function

Glucocorticoid

Safety Profile

Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits toxic fumes of F-.