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2-Bromo-5-methylthiophene

Uses
Product Name
2-Bromo-5-methylthiophene
CAS No.
765-58-2
Chemical Name
2-Bromo-5-methylthiophene
Synonyms
2-Bromo-5-methylthio;bromomethylthiophene;2-BROMO-5-METHYLTHIOPHENE;5-Methyl-2-bromothiophene;5-Bromo-2-methylthiophene;2-BROMO-5-METHYLTHIOPHENOL;Thiophene, 2-bromo-5-methyl-;2-BROMO-5-METHYLTHIOPHENE,96%;2-BroMo-5-Methylthiophene, 95+%;2-Bromo-5-methylthiophene ISO 9001：2015 REACH
CBNumber
CB4684448
Molecular Formula
C5H5BrS
Formula Weight
177.06
MOL File
765-58-2.mol
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2-Bromo-5-methylthiophene Property

Boiling point:
65 °C/15 mmHg (lit.)
Density 
1.552 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.569(lit.)
Flash point:
173 °F
storage temp. 
2-8°C
form 
Liquid Which May Contain Some Precipitate
Specific Gravity
1.552
color 
Yellow
InChI
InChI=1S/C5H5BrS/c1-4-2-3-5(6)7-4/h2-3H,1H3
InChIKey
ACDLOOGOFKSUPO-UHFFFAOYSA-N
SMILES
C1(Br)SC(C)=CC=1
CAS DataBase Reference
765-58-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38-22
Safety Statements 
23-36/37/39-37/39-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
515485
Product name
2-Bromo-5-methylthiophene
Purity
95%
Packaging
1g
Price
$36.7
Updated
2022/05/15
TCI Chemical
Product number
B1540
Product name
2-Bromo-5-methylthiophene (stabilized with Copper chip + NaHCO3)
Purity
>98.0%(GC)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
B1540
Product name
2-Bromo-5-methylthiophene (stabilized with Copper chip + NaHCO3)
Purity
>98.0%(GC)
Packaging
25g
Price
$118
Updated
2025/07/31
TRC
Product number
B697805
Product name
2-Bromo-5-methylthiophene
Packaging
1g
Price
$45
Updated
2021/12/16
TRC
Product number
B697805
Product name
2-Bromo-5-methylthiophene
Packaging
100g
Price
$220
Updated
2021/12/16
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2-Bromo-5-methylthiophene Chemical Properties,Usage,Production

Uses

2-Bromo-5-methylthiophene is a heterocyclic compound that can be used as an intermediate in organic synthesis.

Chemical Properties

Yellow liquid

Synthesis

554-14-3

765-58-2

General procedure for the synthesis of 2-bromo-5-methylthiophene from 2-methylthiophene: A bromine solution was prepared by dissolving 48.0 g of bromine (0.3 mol) in 260 cm3 dioxane. This bromine solution was slowly added dropwise under stirring conditions to a solution of 29.4 g 2-methylthiophene (0.3 mmol) dissolved in 140 cm3 dioxane. The reaction mixture was stirred continuously for 3 hours at room temperature. Subsequently, the reaction system was cooled to 0 °C and saturated aqueous sodium bicarbonate solution was carefully added to neutralize the reaction. The mixture was extracted with ethyl acetate and the organic layer was separated. The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to remove the solvent. The residue was purified by distillation to give 37.2 g 2-bromo-5-methylthiophene (0.21 mol, 70% yield). Boiling point: 68-70 °C (20 mbar). 1H NMR (400 MHz, CDCl3): δ = 2.42 (s, 3H), 6.51 (d, 1H, J = 3.6 Hz), 6.83 (d, 1H, J = 3.6 Hz) ppm. LC-MS: retention time tR = 1.65 min; MS: m/z = 176, 178 ([M+ 1]+, [M+3]+).

References

[1] Journal of Organic Chemistry, 2014, vol. 79, # 4, p. 1836 - 1841
[2] Synthesis, 2002, # 9, p. 1133 - 1135
[3] Green Chemistry, 2018, vol. 20, # 19, p. 4448 - 4452
[4] Synthesis, 2011, # 2, p. 207 - 209
[5] European Journal of Organic Chemistry, 2018, vol. 2018, # 20, p. 2592 - 2602

2-Bromo-5-methylthiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-methylthiophene Suppliers

Americas 1 Canada 2 China 200 Europe 1 France 1 Germany 4 India 5 Japan 3 Slovakia 2 Switzerland 1 Ukraine 1 United Kingdom 14 United States 29 Global 264
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View Lastest Price from 2-Bromo-5-methylthiophene manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
2-Bromo-5-methylthiophene 765-58-2
Price
US $0.00-0.00/KS
Min. Order
1KS
Purity
98%
Supply Ability
2000
Release date
2025-04-18
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-Bromo-5-methylthiophene 765-58-2
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2-Bromo-5-methylthiophene 765-58-2
Price
US $200.00-95.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-22

765-58-2, 2-Bromo-5-methylthiopheneRelated Search:

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