2-Bromo-5-methylthiophene

Uses

Product Name: 2-Bromo-5-methylthiophene
CAS No.: 765-58-2
Chemical Name: 2-Bromo-5-methylthiophene
Synonyms: 2-Bromo-5-methylthio;bromomethylthiophene;2-BROMO-5-METHYLTHIOPHENE;5-Methyl-2-bromothiophene;5-Bromo-2-methylthiophene;2-BROMO-5-METHYLTHIOPHENOL;Thiophene, 2-bromo-5-methyl-;2-BROMO-5-METHYLTHIOPHENE,96%;2-BroMo-5-Methylthiophene, 95+%;2-Bromo-5-methylthiophene ISO 9001：2015 REACH
CBNumber: CB4684448
Molecular Formula: C5H5BrS
Formula Weight: 177.06
MOL File: 765-58-2.mol

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2-Bromo-5-methylthiophene Property

Boiling point:: 65 °C/15 mmHg (lit.)
Density: 1.552 g/mL at 25 °C (lit.)
refractive index: n20/D 1.569(lit.)
Flash point:: 173 °F
storage temp.: 2-8°C
form: Liquid Which May Contain Some Precipitate
Specific Gravity: 1.552
color: Yellow
InChI: InChI=1S/C5H5BrS/c1-4-2-3-5(6)7-4/h2-3H,1H3
InChIKey: ACDLOOGOFKSUPO-UHFFFAOYSA-N
SMILES: C1(Br)SC(C)=CC=1
CAS DataBase Reference: 765-58-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22-36/37/38-22
Safety Statements: 23-36/37/39-37/39-26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 515485
Product name: 2-Bromo-5-methylthiophene
Purity: 95%
Packaging: 1g
Price: $36.7
Updated: 2022/05/15

TCI Chemical

Product number: B1540
Product name: 2-Bromo-5-methylthiophene (stabilized with Copper chip + NaHCO3)
Purity: >98.0%(GC)
Packaging: 5g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: B1540
Product name: 2-Bromo-5-methylthiophene (stabilized with Copper chip + NaHCO3)
Purity: >98.0%(GC)
Packaging: 25g
Price: $118
Updated: 2025/07/31

TRC

Product number: B697805
Product name: 2-Bromo-5-methylthiophene
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: B697805
Product name: 2-Bromo-5-methylthiophene
Packaging: 5g
Price: $55
Updated: 2021/12/16

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2-Bromo-5-methylthiophene Chemical Properties,Usage,Production

Uses

2-Bromo-5-methylthiophene is a heterocyclic compound that can be used as an intermediate in organic synthesis.

Chemical Properties

Yellow liquid

Synthesis

554-14-3

765-58-2

General procedure for the synthesis of 2-bromo-5-methylthiophene from 2-methylthiophene: A bromine solution was prepared by dissolving 48.0 g of bromine (0.3 mol) in 260 cm3 dioxane. This bromine solution was slowly added dropwise under stirring conditions to a solution of 29.4 g 2-methylthiophene (0.3 mmol) dissolved in 140 cm3 dioxane. The reaction mixture was stirred continuously for 3 hours at room temperature. Subsequently, the reaction system was cooled to 0 °C and saturated aqueous sodium bicarbonate solution was carefully added to neutralize the reaction. The mixture was extracted with ethyl acetate and the organic layer was separated. The organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to remove the solvent. The residue was purified by distillation to give 37.2 g 2-bromo-5-methylthiophene (0.21 mol, 70% yield). Boiling point: 68-70 °C (20 mbar). 1H NMR (400 MHz, CDCl3): δ = 2.42 (s, 3H), 6.51 (d, 1H, J = 3.6 Hz), 6.83 (d, 1H, J = 3.6 Hz) ppm. LC-MS: retention time tR = 1.65 min; MS: m/z = 176, 178 ([M+ 1]+, [M+3]+).

References

[1] Journal of Organic Chemistry, 2014, vol. 79, # 4, p. 1836 - 1841
[2] Synthesis, 2002, # 9, p. 1133 - 1135
[3] Green Chemistry, 2018, vol. 20, # 19, p. 4448 - 4452
[4] Synthesis, 2011, # 2, p. 207 - 209
[5] European Journal of Organic Chemistry, 2018, vol. 2018, # 20, p. 2592 - 2602

2-Bromo-5-methylthiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-methylthiophene Suppliers

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View Lastest Price from 2-Bromo-5-methylthiophene manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 2-Bromo-5-methylthiophene 765-58-2
Price: US $0.00-0.00/KS
Min. Order: 1KS
Purity: 98%
Supply Ability: 2000
Release date: 2025-04-18

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Bromo-5-methylthiophene 765-58-2
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 2-Bromo-5-methylthiophene 765-58-2
Price: US $200.00-95.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-22

765-58-2, 2-Bromo-5-methylthiopheneRelated Search:

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2-Bromo-5-methylthiophene, stabilised with Copper (0.1%) and Sodium bicarbonate (0.4%), 95%

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2-BROMO-5-METHYLTHIOPHENE

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2-Bromo-5-methylthiophene ISO 9001：2015 REACH

765-58-2

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