N-(2,6-Diphenylmethyl)-1-piperazine acetylamine
- Product Name
- N-(2,6-Diphenylmethyl)-1-piperazine acetylamine
- CAS No.
- 5294-61-1
- Chemical Name
- N-(2,6-Diphenylmethyl)-1-piperazine acetylamine
- Synonyms
- RZ-2;RS 94287;CVT-2738;EC 610-916-8;UNII-NYS3I6283H;RANOLAZINE MOMOAMIDE;Ranolazine impurity G;1-piperazin acetylamine;CVT-2738, 10 mM in DMSO;Ranolazine Related CoMpound C
- CBNumber
- CB4686477
- Molecular Formula
- C14H21N3O
- Formula Weight
- 247.34
- MOL File
- 5294-61-1.mol
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Property
- Melting point:
- 110-112°C
- Boiling point:
- 411.2±45.0 °C(Predicted)
- Density
- 1.101±0.06 g/cm3(Predicted)
- vapor pressure
- 0-0Pa at 20-25℃
- storage temp.
- -20°C Freezer
- solubility
- DMSO, Methanol
- pka
- 14.62±0.70(Predicted)
- form
- Crystalline Powder
- color
- Light gray
- InChIKey
- NJKRFQIWDJSYOK-UHFFFAOYSA-N
- LogP
- 0.74 at 20℃ and pH12
- CAS DataBase Reference
- 5294-61-1(CAS DataBase Reference)
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934990002
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D4319
- Product name
- N-(2,6-Dimethylphenyl)-1-piperazineacetamide
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $34
- Updated
- 2022/04/27
- Product number
- D4319
- Product name
- N-(2,6-Dimethylphenyl)-1-piperazineacetamide
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- D476950
- Product name
- N-(2,6-Dimethylphenyl)-1-piperazineacetamide
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FD75438
- Product name
- N-(2,6-Dimethylphenyl)-1-piperazineacetamide
- Packaging
- 100g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 038200
- Product name
- N-(2,6-Dimethylphenyl)-2-piperazin-1-ylacetamide
- Packaging
- 500mg
- Price
- $189
- Updated
- 2021/12/16
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Chemical Properties,Usage,Production
Chemical Properties
Pale Beige Solid
Uses
A metabolite of Ranolazine.
Synthesis
142-63-2
1131-01-7
5294-61-1
The general procedure for the synthesis of N-(2,6-dimethylphenyl)-1-piperazine acetamide from piperazine hexahydrate and 2,6-dimethylchloroacetanilide was as follows: 58.3 g (0.3 mol) of piperazine hexahydrate was dissolved in 230 ml of ethanol, followed by the addition of 50.0 g (0.25 mol) of 2-chloro-N-(2,6-dimethylphenyl)acetamide. The reaction mixture was heated under reflux conditions for 3 hours until the reaction was complete. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure followed by addition of 80 ml of water. The mixture was extracted with water and dichloromethane, and after separation of the organic layer, it was concentrated under vacuum at 60 °C to give 39.4 g of N-(2,6-dimethylphenyl)-1-piperazine acetamide in 63% yield. The product was characterized by 1HNMR (CDCl3): δ 2.23-2.27 (s, 6H), 2.67 (s, 4H), 2.96-2.98 (t, 4H), 3.19-3.21 (s, 2H), 7.08-7.26 (m, 3H), 8.69 (s, 1H).
References
[1] Patent: US2013/90475, 2013, A1. Location in patent: Paragraph 0029; 0030
N-(2,6-Diphenylmethyl)-1-piperazine acetylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-(2,6-Diphenylmethyl)-1-piperazine acetylamine manufacturers
- Product
- N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1
- Price
- US $125.00/KG
- Min. Order
- 1Kg/Bag
- Purity
- 99
- Supply Ability
- 10T
- Release date
- 2021-06-08
- Product
- N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- N-(2,6-Diphenylmethyl)-1-piperazine acetylamine 5294-61-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08