ChemicalBook > CAS DataBase List > 5-Aminoisophthalic acid

5-Aminoisophthalic acid

Description Reference

Product Name: 5-Aminoisophthalic acid
CAS No.: 99-31-0
Chemical Name: 5-Aminoisophthalic acid
Synonyms: 5-AMINOISOPHTHALIC;5-AIPA;5-AMINOISOPHTHALATE;5-AMINOISOPHTHALIC ACID HYDRATE;5-AminoisophthaL;3,5-Dicarboxyaniline.;5-amino-m-phthalic Acid;AMINOISOPHTHALIC(5-) ACID;5-Aminoisophthalicacid,95%;5-AMINO-1,3-ISOPHTHALIC ACID
CBNumber: CB4689650
Molecular Formula: C8H7NO4
Formula Weight: 181.15
MOL File: 99-31-0.mol

Less

5-Aminoisophthalic acid Property

Melting point:: >300 °C (lit.)
Boiling point:: 314.24°C (rough estimate)
Density: 1.4283 (rough estimate)
refractive index: 1.5468 (estimate)
storage temp.: Store below +30°C.
pka: 3.69±0.10(Predicted)
form: Granular Powder
color: White to cream
Water Solubility: INSOLUBLE
BRN: 2805628
InChI: InChI=1S/C8H7NO4/c9-6-2-4(7(10)11)1-5(3-6)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13)
InChIKey: KBZFDRWPMZESDI-UHFFFAOYSA-N
SMILES: C1(C(O)=O)=CC(N)=CC(C(O)=O)=C1
CAS DataBase Reference: 99-31-0(CAS DataBase Reference)
EPA Substance Registry System: 5-Aminoisophthalic acid (99-31-0)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 9
TSCA: Yes
HS Code: 29224995
Toxicity: LD50 orally in Rabbit: 1600 mg/kg

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 186279
Product name: 5-Aminoisophthalic acid
Purity: 94%
Packaging: 25g
Price: $39
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.01246
Product name: 5-Aminoisophthalic acid
Purity: for synthesis
Packaging: 50g
Price: $57.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 186279
Product name: 5-Aminoisophthalic acid
Purity: 94%
Packaging: 100g
Price: $66.55
Updated: 2025/07/31

TCI Chemical

Product number: A1290
Product name: 5-Aminoisophthalic Acid Hydrate
Purity: >98.0%(T)
Packaging: 25g
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: A1290
Product name: 5-Aminoisophthalic Acid Hydrate
Purity: >98.0%(T)
Packaging: 100g
Price: $81
Updated: 2025/07/31

Less

5-Aminoisophthalic acid Chemical Properties,Usage,Production

Description

It is usually used as the intermediate or raw material in the organic synthesis. For example, this chemical can be selected as the raw material to prepare three lanthanide metal organic frameworks (MOFs) with typical structural features of one-dimensional ladder-like chain, two-dimensional layer, and three-dimensional framework.¹ Moreover, this substance is chosen as the reactant to fabricate new metal complexes with 5-(1H-imidazol-4-ylmethyl)aminoisophthalic acid, which have good electrocatalytic activities toward the reduction of H2O2 in phosphate buffer (pH=5.5) solution.² In addition, as the active reactant, this chemical has been demonstrated to assist in the synthesis of a chiral, radically homopolymerizable methacrylamide dendrimer with eight ester groups.³

Reference

Jin, H. G.; Yan, Y. Z.; Li, J.; Gu, Z. G.; Chen, J. H.; Liu, Y. T.; Zheng, Z. P.; Zhan, Q. G.; Cai, Y. P., 1-D to 3-D lanthanide coordination polymers constructed from 5-aminoisophthalic acid and oxalic acid. Inorg. Chem. Commun. 2012, 23, 25-30.
Xu, J.; Su, Z.; Chen, M. S.; Chen, S. S.; Sun, W. Y., New metal complexes with 5-(1H-imidazol-4-ylmethyl)aminoisophthalic acid: Syntheses, structures, electrochemistry and electrocatalysis. Inorg. Chim. Acta 2009, 362, 4002-4008.
Draheim, G.; Ritter, H., POLYMERIZABLE DENDRIMERS SYNTHESIS OF A SYMMETRICALLY BRANCHED METHACRYL DERIVATIVE BEARING 8 ESTER GROUPS. Macromol. Chem. Phys. 1995, 196, 2211-2222.

Chemical Properties

Light beige-brown crystalline powder

Uses

5-Aminoisophthalic acid is a useful biochemical for proteomics research.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

618-88-2

99-31-0

In a 3L four-neck flask equipped with a mechanical stirrer, 211.1 g (1.0 mol, 1.0 eq.) of 5-nitroisophthalic acid and 160.0 g (4.0 mol, 4.0 eq.) of sodium hydroxide were dissolved in 2L of water. A thermometer was installed and the mixture was stirred for 1 hour until the system was clarified. Subsequently, 10 g of Nguyenay nickel was added and the temperature was slowly raised to 30-35°C. At this temperature, 125.0 g (2.0 mol, 2.0 eq.) of 80% hydrazine hydrate was added dropwise for a controlled drop time of 30 minutes. After dropwise addition, stirring was continued for 30 min to ensure complete reaction. At the end of the reaction, the pH of the filtrate was adjusted to 3.5-4.0 with acetic acid and a large amount of white solid was precipitated. The precipitate was collected by filtration and dried to give 172.0 g of 5-aminoisophthalic acid in 95% yield and 99.7% purity.

References

[1] Nucleosides and Nucleotides, 1999, vol. 18, # 2, p. 291 - 305
[2] Patent: CN106748840, 2017, A. Location in patent: Paragraph 0020; 0021; 0022; 0023; 0024; 0025
[3] Justus Liebigs Annalen der Chemie, 1870, vol. 153, p. 285
[4] Journal fuer Praktische Chemie (Leipzig), 1882, vol. <2> 25, p. 491
[5] Chemische Berichte, 1917, vol. 50, p. 448

5-Aminoisophthalic acid Preparation Products And Raw materials

Raw materials

Preparation Products

pigment yellow 155

Less

5-Aminoisophthalic acid Suppliers

Americas 1 Belgium 1 Canada 1 China 395 Czech Republic 3 Europe 5 Germany 7 India 54 Italy 1 Japan 8 Slovakia 1 South Korea 2 Switzerland 4 Ukraine 2 United Kingdom 13 United States 41 Global 539

Yangzhou juhechang Technology Co., Ltd

Tel: 0514-0514-83662002 13073488988
Fax: 0514-83662002
Email: 13073488988@163.com
Country: China
ProdList: 39
Advantage: 58

Jay Chemicals

Tel: 13732234254
Email: yogesh.dama@jaychemicals.co.in
Country: China
ProdList: 38
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Changzhou Sunchem Pharmaceutical Chemical Material Co.,Ltd.

Tel: 0519-85195575 15861192208
Fax: 85195585
Email: 850305@sunkechem.com
Country: China
ProdList: 77
Advantage: 69

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Zhejiang Jianfeng Haizhou Pharmaceutical Co., Ltd.

Tel: 0576-88221739
Fax: +86 (576) 88811295
Email: sales@haizhoupharm.com
Country: China
ProdList: 44
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6945
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

RYSS TECH LTD

Tel: 400-188-0725 +86 21 34310725 13611771617
Fax: +86 21 34311076
Country: China
ProdList: 2002
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Shanghai Sunway Pharmaceutical Technology Co., Ltd

Tel: 18270980682
Fax: 021 51613951
Email: mlcheng@sunwaypharm.cn
Country: China
ProdList: 8669
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7247
Advantage: 62

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

Beijing Taiya Jie Technology Development Co., Ltd.

Tel: 021-33690831-8001 13552411790
Fax: 021-33690831
Email: postmaster@tyjchem.cn
Country: China
ProdList: 1542
Advantage: 55

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2744
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Beijing innoChem Science & Technology Co.,Ltd.

Tel: 400-810-7969 010-59572699
Fax: 010-59572688
Email: ningzi.li@inno-chem.com.cn
Country: China
ProdList: 6134
Advantage: 55

Nanjing Norris-Pharm Technology Co., Ltd

Tel: 18652989687
Fax: +86-25-52131256
Email: sales@norris-pharm.com
Country: China
ProdList: 8878
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Cantotech Chemicals, Ltd.

Tel: 86-0755-86635001
Fax: 86-0755-22642228
Email: cantotech@126.com
Country: China
ProdList: 4566
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Synmedia Chemical Co., Ltd.

Tel: 021-38681880 13817889927
Fax: 0213390-8196
Email: sales@synmedia-chem.com
Country: China
ProdList: 249
Advantage: 58

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7782
Advantage: 58

Quzhou Juhua Friendship Co., Ltd

Tel: 0570-3066667
Fax: 0570-3063388
Country: China
ProdList: 3930
Advantage: 58

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Country: China
ProdList: 2930
Advantage: 58

Zhengzhou ALFA Chemical Co., Ltd.

Tel: 0371-53732842 15981811963
Fax: 0371-86239377
Email: 1758257485@qq.com
Country: China
ProdList: 950
Advantage: 56

Less

View Lastest Price from 5-Aminoisophthalic acid manufacturers

Jinan Finer Chemical Co., Ltd

Product: 5-Aminoisophthalic acid 99-31-0
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 500mt/year
Release date: 2021-07-28

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Aminoisophthalic acid 99-31-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-17

Asia Chem I and E (Jiangsu) Co Ltd

Product: 5-Aminoisophthalic acid 99-31-0
Price: US $34.88/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 99.00%HPLC
Supply Ability: 5tons/month
Release date: 2021-09-22

99-31-0, 5-Aminoisophthalic acidRelated Search:

Isopropyl 3-aminocrotonate Lithium diisopropylamide 6-Aminocaproic acid 2-AMINODIETHYLMALONATE Methyl anthranilate 4-Aminobenzoic acid Ethyl 2-(Chlorosulfonyl)acetate Isophthalic acid 5-Hydroxyisophthalic acid DL-ALPHA-AMINOPIMELIC ACID Folic acid Glycine Anthranilic acid 3,5-BIS(METHOXYCARBONYL)PHENYL ISOCYANATE Broxitalamic acid Dimethyl 5-nitroisophthalate NITROTHAL-ISOPROPYL Diethyl 5-nitroisophthalate

5-amino-3-benzenedicarboxylicacid

5-AMINO-1,3-ISOPHTHALIC ACID

5-AMINO-1,3-BENZENEDICARBOXYLIC ACID

5-AMINOISOPHTHALIC

5-AMINOISOPHTHALIC ACID

5-AMINOISOPHTHALIC ACID HYDRATE

AMINOISOPHTHALIC(5-) ACID

5-AminoisophthaL

5-AMINOBENZENE-1,3-DICARBOXYLIC ACID

5-AIPA

5-AMINO-ISO-PHTHALIC ACID 94%

5-amino-m-phthalic Acid

5-Aminoisophthalicacid,95%

5-Aminoisophthalic acid, 98+%

1,3-Benzenedicarboxylic acid, 5-amino-

3,5-Dicarboxyaniline.

5-AMINOISOPHTHALATE

5-AMINOBENZENE-1,3-DICARBOXYLIC ACID / 5-AMINOISOPHTHALIC ACID

5-Aminoisophthalic acid (5-AIPA)

5-Aminoisophthalic acid,5-Aminobenzene-1,3-dicarboxylic acid

5-AMinoisophthalic acid, 98+% 100GR

5-AMinoisophthalic acid, 98+% 25GR

5-Aminobenzene-1,3-dicarboxylic acid, 3,5-Dicarboxyaniline

5- aMinobenzene between two forMic acid

5- between aMino acid (5-aMino-acid peptide iso)

5-AMinoisophthalic Acid, 97% (on dry substance)

5-AMINOISOPHTHALIC ACID FOR SYNTHESIS

5-AminoisophthalicAcidHydrate&gt

5-Aminoisophthalic acid, 98%, reagent grade

5-Aminoisophthalic Acid (5-AIPA) pure, 99%

6?,7?:15?,16?-DiMethylene-5?-hydroxy-3-oxo-17a- pregnane-21,17-carbolactone

5 minoisophthalic acid

99-31-0

88-31-0

C8H7NO4xH2O

NH2C6H3COOH2

H2NC6H313CO2H2

C8H7NO4H2O

Aromatic Amino Acids

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Phthalic Acids, Esters and Derivatives

Organic acids

bc0001

99-31-0