3-Dimethylaminopropylamine Property

Melting point:

-60 °C

Boiling point:

133 °C(lit.)

Density 

0.812 g/mL at 25 °C(lit.)

vapor density 

3.6 (vs air)

vapor pressure 

5 mm Hg ( 20 °C)

refractive index 

n20/D 1.435(lit.)

Flash point:

90 °F

storage temp. 

Store below +30°C.

form 

Liquid

pka

10.13±0.10(Predicted)

color 

Clear

Odor

ammoniacal odor

PH

12.7 (100g/l, H2O, 20℃)

explosive limit

2.3-12.35%(V)

Water Solubility 

SOLUBLE

FreezingPoint 

-70℃

Sensitive 

Air Sensitive

BRN 

605293

InChIKey

IUNMPGNGSSIWFP-UHFFFAOYSA-N

LogP

-0.352 at 25℃

CAS DataBase Reference

109-55-7(CAS DataBase Reference)

NIST Chemistry Reference

1,3-Propanediamine, N,N-dimethyl-(109-55-7)

EPA Substance Registry System

3-(Dimethylamino)propylamine (109-55-7)

Safety

Hazard Codes 

C

Risk Statements 

10-22-34-43-21/22

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2733 3/PG 3

WGK Germany 

2

RTECS 

TX7525000

Autoignition Temperature

215 °C

TSCA 

Yes

HazardClass 

8

PackingGroup 

II

HS Code 

29212900

Hazardous Substances Data

109-55-7(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 1640 mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P403+P235Store in a well-ventilated place. Keep cool.

3-Dimethylaminopropylamine Chemical Properties,Usage,Production

Description

Dimethylaminopropylamine is an aliphatic amine present in amphoteric surfactants such as liquid soaps and shampoos. It is present as an impurity responsible for allergy from cocamidopropylbetaine. It is structurally similar to diethylaminopropylamine. It is also used as a curing agent for epoxy res ins and as an organic intermediate in chemical syntheses (ion exchangers, additives for flocculants, cosmetics and fuel additives, dyes and pesticides).

Chemical Properties

clear liquid. soluble in water and organic solvents.

Uses

N,N-Dimethyl-1,3-propylenediamine is a useful catalyst for Knoevenagel condensation. It is also a useful hardening agent for expoxy resin.

Uses

3-(Dimethylamino)propylamine is an intermediate substance in the synthesis of alkylamidopropyldimethylamines/alkylamidobetaines; found as an impurity in cosmetic surfactants present in e.g. shampoos; hardener of epoxy resins; additive in fue!, dyes, pesticides and binding agents; in the production of ion-exchangers.

Uses

Useful for cleavage of N-alkylphthalimide derivatives to give primary amines, as an alternative to methyl hydrazine. DMAPA is also used directly as a hardener in epoxy resins in the plastics industry, as a cross linking agent for cellulose fibers in the paper industry and as an anti-shriking agent for leather. It is used as an intermediate in the production of binding agents, ion-exchange materials, flocculating agents (water treatment), cosmetic agents, washing and cleaning agents (betaines), additive for petrol and other fuels, polyurethane fibers and lubricants, dyes, agrochemicals, agents used in the photographic and textile industries.

Production Methods

3-Dimethylaminopropylamine is produced by addition of dimethylamine to acrylonitrile and subsequent hydrogenation in the presence of ammonia.

General Description

Dimethylaminopropylamine is a colorless liquid. (NTP, 1992)

Air & Water Reactions

Highly flammable. Temperature sensitive and possibly sensitive to air. Water soluble.

Reactivity Profile

3-Dimethylaminopropylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

3-Dimethylaminopropylamine is flammable.

Toxicology

There are indications of contact and possibly respiratory allergy in relation to occupational exposure. Less than 0.9 ppm of 3-dimethylaminopropylamine in the workplace air may adversely affect respiratory function. The skin-sensitizing potential was verified in an animal study. In an oral 28-d study with rats (gavage, 7 times per week.), clinical symptoms including pulmonary and cardiac failure were noted at 250 mg kg ^-1 d ^-1, but no treatment-related effects at a level of 50 mg kg ^-1 d ^-1.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin and eye irritant. Very flammable when exposed to heat, flame, or oxidmers. Reaction with 1,2dichloroethane produces explosive acetylene gas. This and other amines igmte on contact with cellulose nitrate of hgh surface area. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NO,. See also AMINES