3-Amino-4-iodobenzotrifluoride
- Product Name
- 3-Amino-4-iodobenzotrifluoride
- CAS No.
- 105202-02-6
- Chemical Name
- 3-Amino-4-iodobenzotrifluoride
- Synonyms
- 3-AMINO-4-IODOBENZOTRIFLUORIDE;3-Amino-4-iodobenzotrifluoride98%;3-Amino-4-iodobenzotrifluoride 98%;Benzenamine, 2-iodo-5-(trifluoromethyl)-;2-Iodo-5-(trifluoromethyl)aniline【3-Amino-4-iodobenzotrifluoride】;3-AMino-4-iodobenzotrifluoride[2-Iodo-5-(trifluoroMethyl)aniline];2-Iodo-5-(trifluoromethyl)aniline, 6-Iodo-alpha,alpha,alpha-trifluoro-m-toluidine
- CBNumber
- CB4695044
- Molecular Formula
- C7H5F3IN
- Formula Weight
- 287.02
- MOL File
- 105202-02-6.mol
3-Amino-4-iodobenzotrifluoride Property
- Boiling point:
- 102-114°C
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- Yellow to brown Liquid
Safety
- Hazard Codes
- Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37/39
- Hazard Note
- Irritant
- HS Code
- 2921490090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A612783
- Product name
- 3-Amino-4-iodobenzotrifluoride
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 3830-K-34
- Product name
- 3-Amino-4-iodobenzotrifluoride
- Purity
- 98%
- Packaging
- 10g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 3830-K-34
- Product name
- 3-Amino-4-iodobenzotrifluoride
- Purity
- 98%
- Packaging
- 1g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- PC2015
- Product name
- 3-Amino-4-iodobenzotrifluoride
- Purity
- 98%
- Packaging
- 250mg
- Price
- $38
- Updated
- 2021/12/16
- Product number
- X2916
- Product name
- 2-Iodo-5-(trifluoromethyl)aniline
- Packaging
- 1g
- Price
- $74
- Updated
- 2021/12/16
3-Amino-4-iodobenzotrifluoride Chemical Properties,Usage,Production
Chemical Properties
colorless to light yellow liquid
Uses
3-Amino-4-iodobenzotrifluoride is a useful intermediate for the preparation of trifluoromethylindoles by coupling-annulation of alkynes with iodo(trifluoromethyl)anilines.
Synthesis
400-97-5
105202-02-6
General procedure for the synthesis of 2-iodo-5-trifluoromethylaniline from 3-nitro-4-iodobenzotrifluoride: Iron powder (750 mg, 13.43 mmol) was added to a mixed HOAc-EtOH solution (10 mL, 1:5, v/v) of 3-nitro-4-iodobenzotrifluoride (850 mg, 2.68 mmol) at 23 °C. The reaction mixture was stirred at 23 °C for 3 h. The reaction was subsequently quenched with saturated NaHCO3 solution (20 mL) and diluted with EtOAc (50 mL). The organic and aqueous layers were separated and the organic layer was washed with deionized water (3 x 10 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel as stationary phase, eluent hexane:EtOAc, 10:1, v/v) to afford 2-iodo-5-trifluoromethylaniline (754 mg, 98% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ = 7.76 (dd, J = 8.2,0.7Hz, 1H), 6.96 (d, J = 1.7 Hz, 1H), 6.72 (ddd, J=8.2,2.0,0.6 Hz, 1H), 4.32 (brs, 2H). Mass spectrum (ESI) m/z: 288.0 [M+H]+.
References
[1] Patent: WO2016/29310, 2016, A1. Location in patent: Paragraph 00357-00359
[2] Patent: US5079245, 1992, A
[3] Angewandte Chemie - International Edition, 2011, vol. 50, # 32, p. 7354 - 7358
[4] Patent: US5998334, 1999, A
[5] Organic Letters, 2017, vol. 19, # 17, p. 4484 - 4487
3-Amino-4-iodobenzotrifluoride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-4-iodobenzotrifluoride manufacturers
- Product
- 3-Amino-4-iodobenzotrifluoride 105202-02-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-10