Endothelin-1 (human, porcine)

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Endothelin-1 (human, porcine)

Description

Product Name: Endothelin-1 (human, porcine)
CAS No.: 117399-94-7
Chemical Name: Endothelin-1 (human, porcine)
Synonyms: Endothelin;ET-1;ENDOTHELIN 1;ET-1, HUMAN;Endothelin 1【pig】;Endotherin 1【rat】;ENDOTHELIN-1(HUMAN);Endotherin 1【mouse】;ET-1, HUMAN, PORCINE;Endothelin 1【canine】
CBNumber: CB4706533
Molecular Formula: C109H159N25O32S5
Formula Weight: 2491.9
MOL File: 117399-94-7.mol

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Endothelin-1 (human, porcine) Property

Boiling point:: 2467.3±65.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: 1% acetic acid: >1 mg/mL
form: powder
color: white
Water Solubility: Soluble in water.
Merck: 13,3610
InChIKey: ZUBDGKVDJUIMQQ-UHFFFAOYSA-N

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Safety

WGK Germany: 3
RTECS: KE9446500
F: 3-10
HS Code: 2937190000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P284Wear respiratory protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E7764
Product name: Endothelin 1
Purity: ≥97% (HPLC), powder
Packaging: 10μg
Price: $64.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: E7764
Product name: Endothelin 1
Purity: ≥97% (HPLC), powder
Packaging: 50μg
Price: $210
Updated: 2024/03/01

Sigma-Aldrich

Product number: E7764
Product name: Endothelin 1
Purity: ≥97% (HPLC), powder
Packaging: 0.1mg
Price: $360
Updated: 2024/03/01

Sigma-Aldrich

Product number: 05-23-3800
Product name: Endothelin 1, Human and Porcine
Purity: Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.
Packaging: 0.1MG
Price: $175
Updated: 2024/03/01

Sigma-Aldrich

Product number: 05-23-3800
Product name: Endothelin 1, Human and Porcine
Purity: Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.
Packaging: 0.5MG
Price: $521
Updated: 2024/03/01

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Endothelin-1 (human, porcine) Chemical Properties,Usage,Production

Description

Endothelin-1 (human, porcine) is an active peptide with strong vasoconstriction effect isolated from the supernatant of cultured porcine aortic endothelial cells. Endothelin 1 has been shown to be present in many mammals, including humans. Although vascular endothelial cells are the main source of endothelin 1, cardiomyocytes, vascular smooth muscle cells, renal tubular epithelial cells and glial cells can all produce endothelin 1, suggesting that endothelin 1 can independently participate in the complex regulatory mechanism of various organs.

Uses

Endothelin-1 (human, porcine) has been used for coating wells in polystyrene ELISA plates. Potent agonist for ETA and ETB endothelia receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.

Application

Endothelin-1 (human, porcine) has been used:
to study its effects on the production of erythropoietin under normoxia and carbon monoxide-induced hypoxia in rat models.
as a protein kinase C (PKC) agonist to study its effects on the phosphorylation of myofilament proteins in rat myocytes.
to induce a hypertrophic-like state to study its effects on contraction pressure in normal and mutated human induced pluripotent stem cells (hiPSC)-derived cardiomyocytes.
in vitro hydrolysis products of macroendothelin-1, a precursor of endothelin-1, and their pharmacodynamic properties in rabbits.
as a receptor for endothelin-1 and its role in G protein-mediated signal transduction Research.

Biological Functions

Endothelins are a family of vasoactive peptides secreted by endothelial cells. The three major endothelin peptides are all composed of 21 amino acids. Endothelins are the most potent vasoconstrictors known. Contraction of vascular smooth muscle in response to endothelin is associated with an increase in intracellular calcium. Increases in endothelin levels have been reported in patients with vasospastic, hypoxic, and ischemic diseases.The two identified isoforms of endothelin receptors have differing affinity for the three endothelin peptides. Selective and nonselective endothelin receptor antagonists are in development for potential use in the treatment of hypertension and other disorders associated with increased vascular resistance.

Biological Activity

Endothelin 1 (human, porcine) is an endogenous potent vasoconstrictor peptide that is an agonist at ETA and ETB receptors. Modulates vascular tone. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide isolated from porcine endothelial cells. ET-1 is widely present at binding sites in blood vessels, heart, kidneys, adrenal glands, lungs, and brain, and its distribution is similar to endothelial cells.

Biochem/physiol Actions

Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1α, and, thus, the production of VEGF.

storage

-20°C (desiccate)

Endothelin-1 (human, porcine) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Endothelin-1 (human, porcine) manufacturers

Career Henan Chemical Co

Product: ENDOTHELIN 1 HUMAN, PORCINE 117399-94-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-12

117399-94-7, Endothelin-1 (human, porcine)Related Search:

IRL-1038 Octreotide H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH BIG ET-1 (1-38) (HUMAN) ENDOTHELIN (16-21) ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT) ET-1（Endothelin-1） Inositol Acid Red 94 BQ-3020 Endothelin-1 (human, porcine) GLYCYL-L-TRYPTOPHAN H-VAL-TRP-OH H-GLY-GLY-TRP-OH H-ILE-TRP-OH ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT) H-ALA-SER-ALA-SER-SER-LEU-MET-ASP-LYS-GLU-ALA-VAL-TYR-PHE-ALA-HIS-LEU-ASP-ILE-ILE-TRP-OH FLUORESCEIN-ENDOTHELIN 1 HUMAN

ET-1

ET-1, HUMAN

ET-1, HUMAN AND PORCINE

ET-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT)

ET-1 (HUMAN, MOUSE, RAT, PIG, BOVINE, DOG)

ET-1, HUMAN, PORCINE

ET-1 (HUMAN, PORCINE, DOG, RAT)

ENDOTHELIN-I, HUMAN, PORCINE

ENDOTHELIN 1, DOG, HUMAN, PORCINE, RAT

ENDOTHELIN-1(HUMAN)

ENDOTHELIN 1, HUMAN AND PORCINE

ENDOTHELIN-1 (HUMAN, BOVINE, DOG, MOUSE, PORCINE, RAT)

ENDOTHELIN-1 (HUMAN, MOUSE, RAT, PIG, BOVINE, DOG)

ENDOTHELIN 1 HUMAN, PORCINE

ENDOTHELIN 1

ENDOTHELIN-1 (HUMAN) (PORCINE, CANINE, RAT, MOUSE, BOVINE)

ENDOTHELIN-1 (HUMAN, PORCINE, DOG, RAT)

ENDOTHELIN-1 HUMAN, PORCINE, RAT, CANINE, MURINE

CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP

CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP HUMAN, PORCINE, RAT, CANINE, MURINE

CSCSSLMDKECVYFCHLDIIW

CSCSSLMDKECVYFCHLDIIW (DISULFIDE BRIDGE: 1-15 AND 3-11)

H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH

H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH (DISULFIDE BRIDGE: 1-15 AND 3-11)

H-CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH, (DISULFIDE BONDS BETWEEN CYS1 AND CYS15/CYS3 AND CYS11)

Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, ≥97.0%(HPLC)

ENDOTHELIN 1, HUMAN, PORCINE, 50 UG*

M.W. 2491.90 C109H159N25O32S5

Endothelin 1【canine】

Endothelin 1【pig】

Endotherin 1【mouse】

Endotherin 1【rat】

CYS-SER-CYS-SER-SER-LEU-MET-ASP-LYS-GLU-CYS-VAL-TYR- PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP(DISULFIDE BRIDGE:CYS1-CYS15, CYS3-CYS11)

ENDOTHELIN-1 ACETATE

Endothelin

Endothelin-1 (huMan, bovine, dog, Mouse, porcine, rat) ET-1 (huMan, bovine, dog, Mouse, porcine, rat)

Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridges Cys1-Cys15 and Cys3-Cys11)

H-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-OH acetate salt (Disulfide bonds between Cys1 and Cys15/Cys3 and Cys11)

Endothelin 1 (swine, human)

Endothelin 1 (swine)

ENDOTHELIN 1 HUMAN, PORCINE USP/EP/BP

High purity CAS 117399-94-7 ENDOTHELIN 1 HUMAN, PORCINE

Endothelin 1 (swine, human) acetate

human) acetate(117399-94-7 free base)

(3S,6S,9S,12S,15S,18S)-3-((1H-Imidazol-4-yl)methyl)-18-((1H-indol-3-yl)methyl)-1-((1R,4S,7S,10S,13S,16S,19S,22S,25R,28S,31R,36R,39R,42S,45S)-31-amino-7-(4-aminobutyl)-39-benzyl-4-(2-carboxyethyl)-10-(carboxymethyl)-42-(4-hydroxybenzyl)-19,22,28-tris(hydroxymethyl)-16-isobutyl-45-isopropyl-13-(2-(methylthio)ethyl)-3,6,9,12,15,18,21,24,27,30,38,41,44,47-tetradecaoxo-33,34,49,50-tetrathia-2,5,8,11,14,17,20,23,26,29,37,40,43,46-tetradecaazabicyclo[23.22.4]henpentacontan-36-yl)-12,15-di((S)-sec-butyl

EDN1 Acitive Peptide

Endothelin 1，acetate salt

Mouse Anti-ET-1(2C4) antibody

Rabbit Anti-ET-1 antibody

Rabbit Anti-Big endothelin-1 antibody

117399-94-7

C109H159O32N25S5

C109H159N25O32S5

多肽抗原

Cell Signaling Enzymes

Biochemicals and Reagents

Application Index