CALPEPTIN
- Product Name
- CALPEPTIN
- CAS No.
- 117591-20-5
- Chemical Name
- CALPEPTIN
- Synonyms
- CS-1747;CALPEPTIN;Z-LEU-NLE-OH;Z-LEU-NLE-CHO;Calpeptin,95%;Z-LEU-NORLEUCINAL;N-CBZ-L-LEUCYL-NORLEUCINAL;BENZYLOXYCARBONYLLEUCYL-NORLEUCINAL;BENZYLOXYCARBONYLDIPEPTIDYL ALDEHYDE;N-BENZYLOXYCARBONYL-L-LEUCYLNORLEUCINAL
- CBNumber
- CB4713515
- Molecular Formula
- C20H30N2O4
- Formula Weight
- 362.46
- MOL File
- 117591-20-5.mol
CALPEPTIN Property
- Melting point:
- 60-75 °C
- Boiling point:
- 494.07°C (rough estimate)
- Density
- 1.1667 (rough estimate)
- refractive index
- 1.6800 (estimate)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO at 15mg/ml
- form
- White to off-white solid
- pka
- 11.14±0.46(Predicted)
- color
- white to beige
- InChIKey
- PGGUOGKHUUUWAF-ROUUACIJSA-N
- CAS DataBase Reference
- 117591-20-5(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- HS Code
- 29242990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 03-34-0051
- Product name
- Calpeptin - CAS 117591-20-5 - Calbiochem
- Purity
- A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain).
- Packaging
- 5mg
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 03-34-0051
- Product name
- Calpeptin - CAS 117591-20-5 - Calbiochem
- Purity
- A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain).
- Packaging
- 25mg
- Price
- $373
- Updated
- 2024/03/01
- Product number
- 03-34-0051
- Product name
- Calpeptin - CAS 117591-20-5 - Calbiochem
- Purity
- A cell-permeable calpain inhibitor (ID?? = 52 nM for calpain-1; ID?? = 34 nM for calpain-2; ID?? = 138 nM for papain).
- Packaging
- 100mg
- Price
- $1070
- Updated
- 2024/03/01
- Product number
- J60481
- Product name
- Calpeptin, 98+%
- Packaging
- 10mg
- Price
- $220
- Updated
- 2023/06/20
- Product number
- J60481
- Product name
- Calpeptin, 98+%
- Packaging
- 50mg
- Price
- $807
- Updated
- 2021/12/16
CALPEPTIN Chemical Properties,Usage,Production
Chemical Properties
white to off-white powder
Uses
Calpeptin is used to to inhibit the activities of cathepsin L and calpain-1. Calpeptin blocked the expression of aspartyl protease cathepsin D, amyloid precursor protein, and calparin. It acts as an inhibitor of the Ca2+-dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. It is shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
Definition
ChEBI: Calpeptin is an amino acid amide.
General Description
Calpeptin (Z-Leu-nLeu-H) is a cell permeable, peptide aldehyde inhibitor. It is more sensitive to calpain I compared to other inhibitors, such as Z-Leu-Met-H and leupeptin. Calpeptin stimulates neurite elongation in differentiating pheochromocytoma (PC12) cells. Calpeptin decreases microgliosis, astrogliosis, axonal damage and neuron and oligodendrocyte death in experimental autoimmune encephalomyelitis (EAE) spinal cord. Therefore, it can be considered as a potent therapeutic for treating EAE and multiple sclerosis (MS).
Biological Activity
Potent, cell-permeable inhibitor of the Ca 2+ -dependent protease, calpain. Prevents collagen- and thrombin-induced platelet aggregation, probably by blocking calpain induced phospholipase C and thromboxane synthase activation. Potent cathepsin L inhibitor. Recently shown to preferentially inhibit a subset of protein-tyrosine phosphatases.
Biochem/physiol Actions
Calpeptin is a rho kinase activator and an inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in apoptosis, long-term potentiation in neurons, and cell cycle progression.
in vitro
calpeptin reduced production of tgf-b1, il-6, angiopoietin-1 and collagen synthesis from lung fibroblasts. calpeptin also reduced both angiopoietin-1-dependent migration and il-6-dependent proliferation of the cells, which could be the underlying mechanism of the preventive effect of calpeptin on pulmonary fibrosis [1].
in vivo
the preventive effect of calpeptin has been examined on bleomycin-induced pulmonary fibrosis in mice. histological examinations and quantitative measurements of related proteins in bleomycin-treated mouse lung tissues with or without calpeptin were performed. calpeptin histologically ameliorated bleomycininduced pulmonary fibrosis in mice. results showed that calpeptin decreased the expression of il-6, tgf-b1, angiopoietin-1 and collagen type ia1 mrna in mouse lung tissues [1].
IC 50
5 nm for human calpain 1
storage
Desiccate at +4°C
References
[1] tabata c,tabata r,nakano t. the calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. clin exp immunol.2010 dec;162(3):560-7.
CALPEPTIN Preparation Products And Raw materials
Raw materials
Preparation Products
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