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Silver sulfadiazine

Product Name
Silver sulfadiazine
CAS No.
22199-08-2
Chemical Name
Silver sulfadiazine
Synonyms
SILVER SULPHADIAZINE;silvadene;SULFADIAZINE SILVER;SILVER(I) SULFADIAZINE;SD-Ag;geben;Dermazin;Nsc625324;dermazine;flamazine
CBNumber
CB4744940
Molecular Formula
C10H9AgN4O2S
Formula Weight
357.14
MOL File
22199-08-2.mol
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Silver sulfadiazine Property

Melting point:
285 °C (dec.)(lit.)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly, Heated), Methanol (Slightly)
form 
powder
color 
White to Off-White
Merck 
14,8903
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
UEJSSZHHYBHCEL-UHFFFAOYSA-N
CAS DataBase Reference
22199-08-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
2
RTECS 
WP1950000
HazardClass 
IRRITANT
HS Code 
2935904000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
481181
Product name
Silver(I) sulfadiazine
Purity
98%
Packaging
5g
Price
$65.1
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2654
Product name
Silver Sulfadiazine
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500MG
Price
$241
Updated
2024/03/01
Sigma-Aldrich
Product number
1612608
Product name
Silver sulfadiazine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$572
Updated
2024/03/01
TCI Chemical
Product number
S0595
Product name
Silver Sulfadiazine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$58
Updated
2024/03/01
TCI Chemical
Product number
S0595
Product name
Silver Sulfadiazine
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$187
Updated
2024/03/01
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Silver sulfadiazine Chemical Properties,Usage,Production

Chemical Properties

solid

Uses

Coordination compound. Antibacterial

Uses

Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.

Uses

Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.

Definition

ChEBI: Silver(1+) sulfadiazinate is a silver salt, a sulfonamidate and a member of pyrimidines. It has a role as an antimicrobial agent and an antibacterial drug. It contains a sulfadiazinate.

Indications

Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell wall. It is used primarily as an adjunct in the prevention and treatment of wound sepsis in patients with second- and third-degree burns and for wound care of chronic ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those sensitive to silver nitrate but resistant to sulfadiazine, have shown good response to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance, and does not cause systemic acidosis. Some patients note a stinging sensation on application, and because this compound can be absorbed, systemic sulfonamide reactions similar to those caused by sulfonamides may occur.

Pharmaceutical Applications

Silver sulfadiazine is extremely insoluble. In addition to the usual activity of sulfonamides it exhibits activity – almost certainly attributable to the silver component – against Ps. aeruginosa and some fungi.
It is variably absorbed after topical application depending on the integrity of the skin. Toxic concentrations may be achieved in patients with extensive burns. It is used topically, mainly for burns, pressure sores and leg ulcers. Central venous catheters impregnated with chlorhexidine and silver sulfadiazine have been developed to reduce bacterial colonization. Other suggested uses include the prevention of infection in skin graft donor sites and cord care in newborn infants.

Pharmaceutical Applications

Silver sulfadiazine is indicated for the prophylaxis and treatment of infections in burn wounds. Silver sulfadiazine is highly insoluble in water, and as a result, it does not cause hypochloraemia in burns in contrast to silver nitrate.
The active ingredient silver sulfadiazine is a sulfur-derived topical antibacterial used primarily on secondand third-degree burns. It is known to be active against many Gram-negative and Gram-positive bacteria as well as against yeast. The cream is kept applied to the burned skin at all times for the duration of the healing period or until a graft is applied. It prevents the growth of a wide array of bacteria, as well as yeast, on the damaged skin. Caution has to be given to large-area application as sulfadiazine levels in the plasma may well reach therapeutic levels that can cause side effects.

Clinical Use

The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.

Veterinary Drugs and Treatments

Silver sulfadiazine cream is a broad spectrum agent which covers bacteria (gram positive and negative) and fungal agents. It has been used extensively in people suffering from skin burns. It is nontoxic to the skin, conjunctiva and cornea and has been used in the last several years for cases of fungal keratitis. Particularly good results have been noted in cases of superficial keratitis prior to development of advanced disease. Clinical response is better when used early in the course of the disease. Treatment with silver sulfadiazine is considered non-conventional in people. It is gaining in popularity in the treatment of equine fungal keratitis by veterinary ophthalmologists. For medico-legal reasons, in very expensive horses in which litigation may be an issue, treatment with more conventional therapy (natamycin) may be indicated first, or consideration can be given to signed consent regarding treatment with silver sulfadiazine. The initial response to this drug has been promising, however.

Veterinary Drugs and Treatments

Topical silver sulfadiazine (SSD) is used topically for prophylaxis and treatment of 2nd and 3rd degree burns. It is also useful in treating localized pyodermas caused by Pseudomonas spp.
SSD has extensive antimicrobial activity and is bactericidal for yeasts and many gram-negative and gram-positive bacteria. SSD acts via disrupting microbial cell membranes and cell walls; this differs from the antibacterial actions of silver nitrate or sodium sulfadiazine.

Silver sulfadiazine Preparation Products And Raw materials

Raw materials

Preparation Products

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Silver sulfadiazine Suppliers

Canada 2 China 303 Europe 2 Germany 2 India 25 Israel 1 Italy 1 Japan 2 Russia 1 Slovakia 1 Slovenia 1 South Korea 1 Switzerland 1 United Kingdom 7 United States 35 Global 385
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8837
Advantage
52
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
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View Lastest Price from Silver sulfadiazine manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Silver sulfadiazine 22199-08-2
Price
US $40.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-05-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Silver sulfadiazine 22199-08-2
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%-102%
Supply Ability
1000KGS
Release date
2021-06-09
Baoji Guokang Bio-Technology Co., Ltd.
Product
Silver sulfadiazine 22199-08-2
Price
US $720.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1-20mt
Release date
2021-06-07

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