3-Bromo-2-hydroxypyridine

Product Name: 3-Bromo-2-hydroxypyridine
CAS No.: 13466-43-8
Chemical Name: 3-Bromo-2-hydroxypyridine
Synonyms: 3-BROMO-2-PYRIDONE;3-BROMO-2-PYRIDINOL;IFLAB-BB F1371-0174;3-BROMO-PYRIDIN-2-OL;3-Bromo-2(1H)-pyridone;3-bromo pyridin-2H -one;3-BROMO-2(1H)-PYRIDINONE;3-bromo-1H-pyridin-2-one;2-hydro-3-bromo pyridine;3-BROMO-2-HYDROXYPYRIDINE
CBNumber: CB4747158
Molecular Formula: C5H4BrNO
Formula Weight: 174
MOL File: 13466-43-8.mol

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3-Bromo-2-hydroxypyridine Property

Melting point:: 179-183 °C
Boiling point:: 336.6±42.0 °C(Predicted)
Density: 1.776±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 10.53±0.10(Predicted)
form: Crystalline Powder
color: White to off-white
Water Solubility: Slightly soluble in water.
BRN: 109846
InChI: InChI=1S/C5H4BrNO/c6-4-2-1-3-7-5(4)8/h1-3H,(H,7,8)
InChIKey: YDUGVOUXNSWQSW-UHFFFAOYSA-N
SMILES: C1(=O)NC=CC=C1Br
CAS DataBase Reference: 13466-43-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36-39
WGK Germany: 3
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 686387
Product name: 3-Bromo-2-hydroxypyridine
Purity: 97%
Packaging: 1g
Price: $124
Updated: 2023/06/20

TCI Chemical

Product number: B2330
Product name: 3-Bromo-2-hydroxypyridine
Purity: >97.0%(GC)
Packaging: 5g
Price: $88
Updated: 2025/07/31

TCI Chemical

Product number: B2330
Product name: 3-Bromo-2-hydroxypyridine
Purity: >97.0%(GC)
Packaging: 25g
Price: $264
Updated: 2025/07/31

Usbiological

Product number: 160464
Product name: 3-Bromo-2-hydroxypyridine
Packaging: 1g
Price: $403
Updated: 2021/12/16

TRC

Product number: B684555
Product name: 3-Bromo-2-hydroxypyridine
Packaging: 1g
Price: $120
Updated: 2021/12/16

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3-Bromo-2-hydroxypyridine Chemical Properties,Usage,Production

Chemical Properties

Light yellow powder

Uses

3-Bromo-2-hydroxypyridine is used in the synthesis of pyrazolopyridines as γ-secratase modulators.

Uses

3-Bromo-2-hydroxypyridine is sued as an active ingredient pharmaceuticals, in medicine.

Synthesis

13534-99-1

13466-43-8

The general procedure for the synthesis of 3-bromo-2-hydroxypyridine from 2-amino-3-bromopyridine was as follows: sodium nitrite (24.2 g, 0.35 mol, 4.84 eq.) was dissolved in water (175 mL) at 0 °C and slowly added dropwise to a solution containing 2-amino-3-bromopyridine (12.5 g, 72.4 mmol) and sulfuric acid (35 mL, 0.66 mol , 9.10 eq.) in a solution of water (175 mL). The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, the reaction mixture was neutralized with sodium hydroxide solution to pH=7. The neutralized solution was extracted with chloroform (3 x 200 mL), the organic phases were combined and washed with brine (200 mL), dried over magnesium sulfate, filtered and concentrated in vacuum to afford the milky white solid product 3-bromo-2-hydroxypyridine (11.3 g, 90% yield). The product was characterized as follows: melting point 183 °C; IR (pure) νmax 3339, 3105, 2991, 2942, 1776, 1650, 1610, 1464 cm-1; 1H NMR (500 MHz, CDCl3) δ 7.87 (dd, J = 7.3, 1.9 Hz, 1H), 7.49 (dd, J = 6.4, 1.9 Hz, 1H), 6.24 (dd, J = 7.3, 6.4 Hz, 1H) ppm; 13C NMR (125 MHz, CDCl3) δ 161.9, 143.9, 134.4, 115.7, 107.7 ppm; HRMS (ESI) m/z [M + Na]+ Calculated value: 195.9369, measured value: 195.9373 (deviation +2.07 ppm).

References

[1] Organic Letters, 2016, vol. 18, # 13, p. 3106 - 3109
[2] Synthesis (Germany), 2016, vol. 48, # 20, p. 3575 - 3588

3-Bromo-2-hydroxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Bromo-2-hydroxypyridine Suppliers

Americas 1 Canada 2 China 198 Europe 3 France 1 Germany 6 India 37 Japan 1 Jordan 1 Switzerland 2 The Netherlands 1 United Kingdom 9 United States 26 Global 288

Specs

Tel: --
Fax: --
Email: info@specs.net
Country: The Netherlands
ProdList: 6833
Advantage: 70

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View Lastest Price from 3-Bromo-2-hydroxypyridine manufacturers

Dideu Industries Group Limited

Product: 3-Bromo-2-hydroxypyridine 13466-43-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-24

Career Henan Chemical Co

Product: 3-Bromo-2-hydroxypyridine 13466-43-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg; 10kg; 100kg
Release date: 2019-08-30

13466-43-8, 3-Bromo-2-hydroxypyridineRelated Search:

2,3,4-Trihydroxybenzoic acid 1-Hexadecylpyridinium bromide Sulfasalazine 3-Aminopyridine Chromium picolinate 2-Hydroxypyridine CHLOROPHOSPHONAZO III Hydroxy silicone oil 3,5-DIBROMO-2-HYDROXYPYRIDINE 3-BROMO-2-HYDROXY-6-PICOLINE 3-BROMO-2-HYDROXY-5-METHYLPYRIDINE 3-BROMO-5-HYDROXYPYRIDINE 98.5+%,3-Hydroxy-5-bromopyridine,5-Bromo-3-hydroxypyridine 5-Bromo-3-pyridinol,3-BROMO-5-HYDROXYPYRIDINE,5-BROMO-3-HYDROXYPYRIDINE 3-BROMO-2-ETHOXYPYRIDINE 3-Bromo-2-hydroxy-5-nitropyridine 3-BROMO-5-CHLORO-2-HYDROXYPYRIDINE 3-Bromo-2-methoxypyridine 3,5-Dibromo-2,6-dimethoxypyridine, 99% Bromine

3-Bromopyridin-2-ol, 3-Bromopyridin-2(1H)-one

3-Bromo-2-pyridinol 3-Bromo-2(1H)-pyridinone 3-Bromo-2-pyridone

IFLAB-BB F1371-0174

3-BROMO-2-HYDROXYPYRIDINE

3-BROMO-2(1H)-PYRIDINONE

3-BROMO-2-PYRIDINOL

3-BROMO-2-PYRIDONE

3-BROMO-PYRIDIN-2-OL

2-HYDROXY-3-BROMOPYRIDINE

3-Bromo-2-Hydroxypyridine99%

3-Bromo-2(1H)-pyridone

2(1H)-Pyridinone,3-broMo-

3-Bromo-2-hydroxypyridine,97%

3-Bromo-2-hydroxypyridine 97%

3-Bromo-2-hydroxypyridine≥ 98.5% (HPLC)

3-bromo-1,2-dihydropyridin-2-one

3-Bromo-2-hydroxypyridine &gt

3-BROMOPYRIDIN-2(1H)-ONE, OR 3-BROMO-2-HYDROXYPYRIDINE

3-Bromo-2-hydroxypyridine ISO 9001：2015 REACH

3-bromo-1H-pyridin-2-one

3-bromo pyridin-2H -one

2-hydro-3-bromo pyridine

13466-43-8

Bromopyridines

Halopyridines

alkyl bromide| alcohol

Building Blocks

C5

C5 to C6

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Bromopyridines

Halopyridines

Pyridines

Pyridine

Pyridine Series