Synthesis
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3,5-Difluoropyridine

Synthesis
Product Name
3,5-Difluoropyridine
CAS No.
71902-33-5
Chemical Name
3,5-Difluoropyridine
Synonyms
3,5-Difluropyridine;3,5-DIFLUOROPYRIDINE;Pyridine, 3,5-difluoro-;3,5-Difluoropyridine>3,5-Difluoropyridine98%;3,5-Difluoropyridine 98%;3,5-Difluoropyridine ISO 9001：2015 REACH
CBNumber
CB4751533
Molecular Formula
C5H3F2N
Formula Weight
115.08
MOL File
71902-33-5.mol
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3,5-Difluoropyridine Property

Boiling point:
92-93°C
Density 
1.256 g/mL at 25 °C
refractive index 
1.4437
Flash point:
9°C
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
clear liquid
pka
0.39±0.20(Predicted)
color 
Colorless to Almost colorless
BRN 
7914363
InChIKey
WRXAZPPGFLETFR-UHFFFAOYSA-N
CAS DataBase Reference
71902-33-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,F,N,Xn
Risk Statements 
36/37/38-50-20/21/22-11
Safety Statements 
26-36/37/39-61-36/37
RIDADR 
1993
WGK Germany 
3
Hazard Note 
Highly Flammable/Irritant
HazardClass 
3
PackingGroup 
II
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H400Very toxic to aquatic life

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
703923
Product name
3,5-Difluoropyridine
Purity
97%
Packaging
5g
Price
$167
Updated
2023/06/20
TCI Chemical
Product number
D4038
Product name
3,5-Difluoropyridine
Purity
>98.0%(GC)
Packaging
1g
Price
$21
Updated
2024/03/01
TCI Chemical
Product number
D4038
Product name
3,5-Difluoropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$81
Updated
2024/03/01
Alfa Aesar
Product number
L19539
Product name
3,5-Difluoropyridine, 98%
Packaging
1g
Price
$52.65
Updated
2024/03/01
Alfa Aesar
Product number
L19539
Product name
3,5-Difluoropyridine, 98%
Packaging
5g
Price
$162.65
Updated
2024/03/01
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3,5-Difluoropyridine Chemical Properties,Usage,Production

Synthesis

Hydrogenolysis of 2,4,6-tribromo-3,5-difluoropyridine occurred rapidly giving quantitative conversion to 3,5-difluoropyridine (5), with an isolated yield by distillation of 63%.

Chemical Properties

Liquid

Preparation

Synthesis of 3,5-Difluoropyridine: A solution of 2,4,6-tribromo-3,5-difluoropyridine (11) (34.0 g, 97 mmol) in DCM (200 cm3) was washed with activated carbon and filtered. A palladium catalyst (3.4 g of a 5% Pd/C commercially available product) and triethylamine (45 cm3, 31.5 g, 312 mmol) were added to the filtrate and the mixture hydrogenated in a Parr apparatus at 4 Bar for 21 h. The mixture was filtered, water (200 cm3) added and extracted into DCM. Distillation of the DCM solution on Fischer-Spaltrohr apparatus gave 3,5-difluoropyridine (7.0 g, 61 mmol, 63%), b.p. 92.5 ·c (Found: C, 52.2; H, 3.0; N, 12.2. C5H3F2N2 requires C, 52.2; H, 3.0; N, 12.2%);
IR spectrum no. 1; mass spectrum no. 1; nrnr spectrum no. 8.

3,5-Difluoropyridine Preparation Products And Raw materials

Raw materials

Pentafluoropyridine Diethyl ether Lithium Aluminum Hydride

Preparation Products

3,5-DIFLUORO-PYRIDIN-4-YLAMINE
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3,5-Difluoropyridine Suppliers

Americas 1 China 148 Europe 3 Germany 4 India 4 Italy 1 Japan 1 Jordan 1 Switzerland 1 United Kingdom 7 United States 22 Global 193
Pure Chemistry Scientific Inc.
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View Lastest Price from 3,5-Difluoropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3,5-Difluoropyridine 71902-33-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-26
Career Henan Chemical Co
Product
3,5-Difluoropyridine 71902-33-5
Price
US $3.00/KG
Min. Order
1KG
Purity
90%-99.9%
Supply Ability
500kg
Release date
2019-07-04

71902-33-5, 3,5-DifluoropyridineRelated Search:

DIPIPERIDINOMETHANE 2,6-Lutidine 2,5-PYRIDINEDICARBOXYLIC ACID Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 2,3,5,6-Tetrafluoropyridine 2 3 5 6-TETRAFLUORO-4-METHYLPYRIDINE 9& 2,3-DIFLUOROPYRIDINE 2,5-DIFLUOROPYRIDINE 2,3,5,6-TETRAFLUORO-4-PYRIDINE-CARBONITRILE 4-(DIMETHYLAMINO)-2,3,5,6-TETRAFLUOROPYRIDINE 4-AMINO-2,3,5,6-TETRAFLUOROPYRIDINE Pentafluoropyridine 2,6-DIFLUOROPYRIDINE 3,4-DIBROMO-2-FLUOROPYRIDINE 5,6-Difluoropyridine-2-carboxylic acid 2,6-DIBROMO-3,5-DIFLUOROPYRIDINE-4-CARBOXYLIC ACID 2,6-DIFLUOROPYRIDINE-3-BORONIC ACID HYDRATE 2,4-DIFLUORO-PYRIDINE

  • 3,5-DIFLUOROPYRIDINE
  • 3,5-Difluoropyridine 98%
  • 3,5-Difluoropyridine98%
  • 3,5-Difluropyridine
  • 3,5-Difluoropyridine&gt
  • Pyridine, 3,5-difluoro-
  • 3,5-Difluoropyridine ISO 9001：2015 REACH
  • 71902-33-5
  • C5H3NF2
  • Fluorine series
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Halides
  • Pyridines
  • Pyridine
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building BlocksHeterocyclic Building Blocks
  • New Products for Chemical Synthesis
  • Fluorin-contained pyridine series