1,2,3,4-TETRAHYDROQUINOLIN-6-OL
- Product Name
- 1,2,3,4-TETRAHYDROQUINOLIN-6-OL
- CAS No.
- 3373-00-0
- Chemical Name
- 1,2,3,4-TETRAHYDROQUINOLIN-6-OL
- Synonyms
- 4-TETRAHYDROQUINOLIN-6-OL;1,2,3,4-Tetrahydro-6-quinolinol;1,2,3,4-TETRAHYDROQUINOLIN-6-OL;1,2,3,4-Tetrahydroquinoline-6-ol;6-Quinolinol, 1,2,3,4-tetrahydro-;6-HYDROXY-1,2,3,4-TETRAHYDROQUINOLINE;5-hydroxy-1,2,3,4-Tetrahydro-quinolin;6-hydroxy-1,2,3,4-Tetrahydro-quinolin;1,2,3,4-tetrahydroquinolin-6-ol hydrochloride;1,2,3,4-TETRAHYDROQUINOLIN-6-OL ISO 9001：2015 REACH
- CBNumber
- CB4756109
- Molecular Formula
- C9H11NO
- Formula Weight
- 149.19
- MOL File
- 3373-00-0.mol
1,2,3,4-TETRAHYDROQUINOLIN-6-OL Property
- Melting point:
- 160 °C
- Boiling point:
- 337.5±31.0 °C(Predicted)
- Density
- 1.141±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Methanol
- form
- Solid
- pka
- 11.48±0.20(Predicted)
- color
- Off-White
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T293840
- Product name
- 1,2,3,4-Tetrahydro-quinoline-6-ol
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- 290048
- Product name
- 1,2,3,4-Tetrahydro-quinoline-6-ol
- Packaging
- 50mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- T293840
- Product name
- 1,2,3,4-Tetrahydro-quinoline-6-ol
- Packaging
- 100mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- P000213308
- Product name
- 6-Hydroxy-1,2,3,4-tetrahydroquinoline
- Purity
- 95%
- Packaging
- 5g
- Price
- $148
- Updated
- 2021/12/16
- Product number
- P000213308
- Product name
- 6-Hydroxy-1,2,3,4-tetrahydroquinoline
- Purity
- 95%
- Packaging
- 25g
- Price
- $517
- Updated
- 2021/12/16
1,2,3,4-TETRAHYDROQUINOLIN-6-OL Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
A potential amoebicide.
Synthesis
120-15-0
3373-00-0
General procedure for the synthesis of 6-hydroxy-1,2,3,4-tetrahydroquinoline from 6-methoxy-1,2,3,4-tetrahydroquinoline: 6-methoxy-1,2,3,4-tetrahydroquinoline (3.00 g, 18.38 mmol) was dissolved in 50 mL of dichloromethane, and boron tribromide (13.81 g, 55.14 mmol) was slowly added at 0 °C. The reaction system was then warmed up to 15 °C with continuous stirring for 2 hours. After completion of the reaction, the reaction solution was concentrated and the reaction was quenched with 5 mL of methanol. To the reaction mixture, 20 mL of saturated sodium bicarbonate solution was added and stirred for 30 minutes. The reaction was extracted three times with 20 mL of ethyl acetate, the organic phases were combined and dried with anhydrous sodium sulfate. The organic phase was concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent ratio: petroleum ether/ethyl acetate from 3:1 to 1:1 gradient elution) to finally obtain 6-hydroxy-1,2,3,4-tetrahydroquinoline (1.95 g, yield 71.11%). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.24 (s, 1H), 6.22-6.35 (m, 3H), 4.93 (br.s, 1H), 3.02-3.10 (m, 2H), 2.57 (t, J = 6.4 Hz, 2H), 1.67-1.80 (m, 2H).
References
[1] Patent: EP3293177, 2018, A1. Location in patent: Paragraph 0222; 0224
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 13, p. 3415 - 3418
1,2,3,4-TETRAHYDROQUINOLIN-6-OL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,2,3,4-TETRAHYDROQUINOLIN-6-OL manufacturers
- Product
- 1,2,3,4-TETRAHYDROQUINOLIN-6-OL 3373-00-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-22
- Product
- 1,2,3,4-TETRAHYDROQUINOLIN-6-OL 3373-00-0
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22
- Product
- 1,2,3,4-TETRAHYDROQUINOLIN-6-OL 3373-00-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kgs
- Release date
- 2020-03-05