4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE
- Product Name
- 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE
- CAS No.
- 16097-63-5
- Chemical Name
- 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE
- Synonyms
- NSC 64344;BUTTPARK 6\01-56;SPECS AG-996/31082064;4-CHLORO-2-METHYLTHIO-6-(TRIFLUOROMETHYL)PYRIMIDINE;Pyrimidine, 4-chloro-2-(methylthio)-6-(trifluoromethyl)-;4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE;4-Chloro-2-(methylthio)-6-(trifluoromethyl)pyrimidine ,97%;4-Chloro-2-(Methylsulfanyl)-6-(trifluoroMethyl)pyriMidine (en);JR-8836, 4-Chloro-2-methylthio-6-(trifluoromethyl)pyrimidine, 97%;4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB4757186
- Molecular Formula
- C6H4ClF3N2S
- Formula Weight
- 228.62
- MOL File
- 16097-63-5.mol
4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE Property
- Melting point:
- 38-39℃ (ethyl acetate ligroine )
- Boiling point:
- 83.5℃ (9.3 Torr)
- Density
- 1.52±0.1 g/cm3(Predicted)
- refractive index
- 1.5050 (25℃)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -5.28±0.32(Predicted)
- form
- Liquid
- color
- Colorless
- Sensitive
- Stench
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 26-36/37/39-45
- Hazard Note
- Irritant/Stench
- HazardClass
- IRRITANT
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C381615
- Product name
- 4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- C11424
- Product name
- 4-Chloro-2-(methylthio)-6-(trifluoromethyl)pyrimidine
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 045340
- Product name
- 4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)-pyrimidine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 045340
- Product name
- 4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)-pyrimidine
- Purity
- >95%
- Packaging
- 1g
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 7H66-7-01
- Product name
- 4-Chloro-2-(methylthio)-6-(trifluoromethyl)pyrimidine
- Packaging
- 500mg
- Price
- $84
- Updated
- 2021/12/16
4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
4-Chloro-2-(methylsulfanyl)-6-(trifluoromethyl)pyrimidine can be used as potent antiviral agents.
Synthesis
16097-62-4
16097-63-5
General procedure for the synthesis of 4-chloro-2-methylthio-6-trifluoromethylpyrimidines from 6-trifluoromethyl-4-hydroxy-2-methylthiopyrimidines: 2-(methylthio)-6-(trifluoromethyl)pyrimidin-4-ol (43-01) (1.4 g, 6.67 mmol) was dissolved in phosphorus oxychloride (POCl3, 15 mL) and the reaction was carried out under reflux for 3 h at 120 °C. The reaction was carried out under vacuum. Upon completion of the reaction, the mixture was cooled to room temperature and the excess POCl3 was subsequently removed under vacuum.The residue was extracted three times with dichloromethane (DCM) and ice water. The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to afford 1.38 g of 4-chloro-2-(methylthio)-6-(trifluoromethyl)pyrimidine as a light yellow oil in 90% yield. Analyzed by liquid chromatography-mass spectrometry (LC-MS, ESI), the molecular ion peak m/z was measured to be 229.0 [C6H5ClF3N2S+], which was consistent with the theoretically calculated value.
References
[1] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 4, p. 407 - 412
[2] Patent: WO2018/14802, 2018, A1. Location in patent: Paragraph 0232
[3] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 1, p. 219 - 223
[4] Patent: WO2010/134478, 2010, A1. Location in patent: Page/Page column 182
4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE Suppliers
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View Lastest Price from 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE manufacturers
- Product
- 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE 16097-63-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07
- Product
- 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE 16097-63-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24
- Product
- 4-CHLORO-2-(METHYLSULFANYL)-6-(TRIFLUOROMETHYL)PYRIMIDINE 16097-63-5
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-24