ChemicalBook > CAS DataBase List > CLOZAPINE N-OXIDE

CLOZAPINE N-OXIDE

Product Name
CLOZAPINE N-OXIDE
CAS No.
34233-69-7
Chemical Name
CLOZAPINE N-OXIDE
Synonyms
CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);Clozapine N-oxide solution;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW;Clozapine N-oxide (4-oxido-piprazinyl);Clozapine N-Oxide (1.0 mg/mL in Methanol);Clozapine N-oxide (4-oxido-piprazinyl) in methanol
CBNumber
CB4759216
Molecular Formula
C18H19ClN4O
Formula Weight
342.82
MOL File
34233-69-7.mol
More
Less

CLOZAPINE N-OXIDE Property

Melting point:
190-248°C
Flash point:
9℃
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
Soluble in DMSO.
form 
powder
pka
6.86±0.20(Predicted)
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey
OGUCZBIQSYYWEF-UHFFFAOYSA-N
More
Less

Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-45-36/37-16-7
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
HP1760000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0832
Product name
Clozapine N-oxide
Packaging
5mg
Price
$232
Updated
2024/03/01
Alfa Aesar
Product number
J67235
Product name
Clozapine N-oxide, 99%
Packaging
5mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
16882
Product name
Clozapine N-oxide
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
16882
Product name
Clozapine N-oxide
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2304
Product name
Clozapine N-oxide hydrochloride
Purity
≥98% (HPLC), Water soluble Clozapine N-oxide
Packaging
5mg
Price
$225
Updated
2024/03/01
More
Less

CLOZAPINE N-OXIDE Chemical Properties,Usage,Production

Description

Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6

Chemical Properties

Yellow Solid

Uses

Clozapine N-oxide has been used:

  • for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
  • for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
  • in behavioral testing in mice and for stimulating (HEK293) cells

Uses

A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors

Definition

ChEBI: Clozapine N-oxide is a dibenzodiazepine.

General Description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

storage

Room temperature (desiccate)

References

1) Eiermann?et al.?(1997),?The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine; Br. J. Clin. Pharmacol.,?44?439 2) Armbruster?et al.?(2007),?Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand; Proc. Natl. Acad. Sci. USA,?104?5163 3) Chen?et al.?(2016),?Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease; Cell Stem Cell,?18?817 4) Vazey and Aston-Jones (2014),?Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease: J. Clin. Invest.,?124?2858 5) Gomez?et al.?(2017)?Chemogenetics revealed: DREADD occupancy and activation via converted clozapine; Science?357?503 6) Marcinkiewcz?et al. (2016)?Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala; Nature?537?97

CLOZAPINE N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CLOZAPINE N-OXIDE Suppliers

Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1637
Advantage
59
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5873
Advantage
58
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4566
Advantage
55
Nanjing XiZe Biotechnology CO., Ltd.
Tel
025-66023220 0086-15250997978
Fax
025-58362220
Email
1511893459@qq.com
Country
China
ProdList
7850
Advantage
55
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
9248
Advantage
55
Artis Biotech Co. Ltd.
Tel
0575-18780151478 18582380095
Fax
0575-89298961
Email
sales@artisbio.com
Country
China
ProdList
2966
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ:65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7296
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9952
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Chemleader Biomedical Co., Limited.
Tel
021-58180488
Fax
021-58180499
Email
sales@Medchemleader.com
Country
China
ProdList
1005
Advantage
58
Shanghai CR Corporation Limited
Tel
021-80270511; 4006653949
Fax
QQ: 2136646215
Email
fred.wen@crcorporation.cn
Country
China
ProdList
10044
Advantage
58
Shenzhen SUNGENING Bio-Medical Co., Ltd.
Tel
0755-28967200 13631290199
Fax
0755-28967200
Email
wxf@sungening.com
Country
China
ProdList
9578
Advantage
60
Chengdu Novel Biomedical Co., Ltd.
Tel
028-85255396 18302801538
Fax
028-85255396
Email
cdnovell@163.com
Country
China
ProdList
2314
Advantage
58
XinYao(Shenzhen) Biological Technology Co., Ltd.
Tel
0755-89880280
Fax
0755-89880280
Email
3004662104@qq.com
Country
China
ProdList
1829
Advantage
58
Shanghai Tube Pharmaceutical Co., Ltd.
Tel
021-54338626 18017892860
Fax
021-54338626
Email
sales@tubepharm.com
Country
China
ProdList
2416
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-010-010-62971590 18548936886
Fax
010-62340519
Email
jack@oka-vip.com
Country
China
ProdList
6897
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Anhui Feixiang Pharmaceutical Technology Co., Ltd.
Tel
13349001619
Email
sales@feixiangpharm.com
Country
China
ProdList
1008
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Shenzhen Botel Biotechnology Co. Ltd.
Tel
0755-22202135 13316968096
Email
1979313431@qq.com
Country
China
ProdList
9020
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Hebei Mojin Biotechnology Co., Ltd
Tel
+86 13288715578 +8613288715578
Email
sales@hbmojin.com
Country
China
ProdList
12834
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
sgtlifesciences pvt ltd
Tel
+8617013299288
Email
dj@sgtlifesciences.com
Country
China
ProdList
12373
Advantage
58
Baoji Guokang Bio-Technology Co., Ltd.
Tel
0917-3909592 13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9312
Advantage
58
Guangzhou Dreampharm Biotechnology Co., Ltd.
Tel
020-36607679 17825480238
Fax
QQ 3008233717
Email
3008233746@qq.com
Country
China
ProdList
9919
Advantage
12
Hangzhou Molot Chemical Technology Co., Ltd.
Tel
+86-(0571)5690 6266 +86-17706505167
Email
sales@morotchem.com
Country
China
ProdList
500
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
More
Less

View Lastest Price from CLOZAPINE N-OXIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Clozapine Noxide 34233-69-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Clozapine N-oxide 34233-69-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Clozapine N-oxide 34233-69-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

34233-69-7, CLOZAPINE N-OXIDERelated Search:


  • e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide
  • CLOZAPINE N-OXIDE
  • 8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE
  • MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
  • Clozapine N-oxide Methanol Adduct
  • Clozapine N-oxide solution
  • Clozapine N-oxide (CNO)
  • 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
  • Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
  • Clozapine N-oxide dihydrochloride NEW
  • Clozapine N-Oxide (1.0 mg/mL in Methanol)
  • Clozapine N-oxide (4-oxido-piprazinyl)
  • 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
  • Clozapine N-OxideQ: What is Clozapine N-Oxide Q: What is the CAS Number of Clozapine N-Oxide Q: What is the storage condition of Clozapine N-Oxide Q: What are the applications of Clozapine N-Oxide
  • Clozapine Impurity 16
  • 3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
  • Clozapine N-Oxide imp
  • 4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
  • Clozapine N-oxide (4-oxido-piprazinyl) in methanol
  • 34233-69-7
  • C18H19ClN4O2HCl
  • C18H19ClN4O
  • Various Metabolites and Impurities
  • Metabolites