ChemicalBook > CAS DataBase List > CLOZAPINE N-OXIDE

CLOZAPINE N-OXIDE

Product Name: CLOZAPINE N-OXIDE
CAS No.: 34233-69-7
Chemical Name: CLOZAPINE N-OXIDE
Synonyms: CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);CNO (Clozapine N-oxide);Clozapine N-oxide[C0832];Clozapine N-oxide solution;CLOZAPINE N-OXIDE, 10 mM in DMSO;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW
CBNumber: CB4759216
Molecular Formula: C18H19ClN4O
Formula Weight: 342.82
MOL File: 34233-69-7.mol

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CLOZAPINE N-OXIDE Property

Melting point:: 190-248°C
Flash point:: 9℃
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: Soluble in DMSO.
form: powder
pka: 6.86±0.20(Predicted)
color: Yellow
biological source: synthetic
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChIKey: OGUCZBIQSYYWEF-UHFFFAOYSA-N
SMILES: N1=C(N2CC[N+]([O-])(C)CC2)C2=CC=CC=C2NC2=CC=C(Cl)C=C12

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Safety

Hazard Codes: Xn,T,F
Risk Statements: 22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements: 26-36-45-36/37-16-7
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: HP1760000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C0832
Product name: Clozapine N-oxide
Packaging: 5mg
Price: $239
Updated: 2025/07/31

TCI Chemical

Product number: C3891
Product name: Clozapine N-Oxide
Packaging: 25MG
Price: $426
Updated: 2025/07/31

Cayman Chemical

Product number: 16882
Product name: Clozapine N-oxide
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 16882
Product name: Clozapine N-oxide
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2304
Product name: Clozapine N-oxide hydrochloride
Purity: ≥98% (HPLC), Water soluble Clozapine N-oxide
Packaging: 5mg
Price: $231
Updated: 2025/07/31

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CLOZAPINE N-OXIDE Chemical Properties,Usage,Production

Description

Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6

Chemical Properties

Yellow Solid

Uses

Clozapine N-oxide has been used:

for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
in behavioral testing in mice and for stimulating (HEK293) cells

Uses

A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors

Definition

ChEBI: Clozapine N-oxide is a dibenzodiazepine.

General Description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

storage

Room temperature (desiccate)

References

[1] BIRGIT EIERMANN. The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine[J]. British journal of clinical pharmacology, 2003, 44 5: 439-446. DOI:10.1046/j.1365-2125.1997.t01-1-00605.x
[2] BLAINE N ARMBRUSTER. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007: 5163-5168. DOI:10.1073/pnas.0700293104
[3] YUEJUN CHEN. Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease.[J]. Cell stem cell, 2016, 18 6: 817-826. DOI:10.1016/j.stem.2016.03.014
[4] ELENA M VAZEY Gary A J. Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease.[J]. Journal of Clinical Investigation, 2014, 124 7: 2858-2860. DOI:10.1172/jci76833
[5] JUAN L. GOMEZ. Chemogenetics revealed: DREADD occupancy and activation via converted clozapine[J]. Science, 2017, 357 6350. DOI:10.1126/science.aan2475
[6] CATHERINE A. MARCINKIEWCZ. Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala[J]. Nature, 2016, 537 7618: 97-101. DOI:10.1038/nature19318

CLOZAPINE N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLOZAPINE N-OXIDE Suppliers

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View Lastest Price from CLOZAPINE N-OXIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Clozapine N-oxide 34233-69-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Clozapine N-oxide 34233-69-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Career Henan Chemical Co

Product: CLOZAPINE N-OXIDE 34233-69-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10t
Release date: 2019-12-20

34233-69-7, CLOZAPINE N-OXIDERelated Search:

2-CHLOROMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDINE pidotiMod iMpurity E Acarbose 4-Chloro-2-propylsulfanyl-pyrimidine (2R,3R)-2-[(1R)-1-[3,5-Bis(trifluoroMethyl)phenyl]ethoxy]-3-(4-fluorophenyl)Morpholine 2-[2-(2-Methyl-5-nitroiMidazol-1-yl)ethoxy]ethanol 5-Nitro-1H-iMidazole-1-ethanol (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Pyridine-N-oxide Pyridine-4-carboxylic acid N-oxide Clozapine EP IMpurity D Trimethylamine N-oxide CLOZAPINE N-OXIDE Clozapine 2-AMINO-4-CHLORODIPHENYLAMINE 2-[(4-METHYLPIPERAZIN-1-YL)METHYL]ANILINE 4-CHLORODIPHENYLAMINE N-DESMETHYLCLOZAPINE

e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide

CLOZAPINE N-OXIDE

8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE

MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS

Clozapine N-oxide Methanol Adduct

Clozapine N-oxide solution

Clozapine N-oxide (CNO)

8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine

Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide

Clozapine N-oxide dihydrochloride NEW

Clozapine N-Oxide (1.0 mg/mL in Methanol)

Clozapine N-oxide (4-oxido-piprazinyl)

5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-

Clozapine N-OxideQ: What is Clozapine N-Oxide Q: What is the CAS Number of Clozapine N-Oxide Q: What is the storage condition of Clozapine N-Oxide Q: What are the applications of Clozapine N-Oxide

Clozapine Impurity 16

3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine

Clozapine N-Oxide imp

4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide

Clozapine N-oxide (4-oxido-piprazinyl) in methanol

Clozapine N-oxide, Metabolite of Clozapine (aqueous solution)

Clozapine N-oxide, Metabolite of Clozapine

CLOZAPINE N-OXIDE, 10 mM in DMSO

CNO (Clozapine N-oxide)

Clozapine N-oxide[C0832]

34233-69-7

C18H19ClN4O2HCl

C18H19ClN4O

Various Metabolites and Impurities

Metabolites