ChemicalBook > CAS DataBase List > CLOZAPINE N-OXIDE

CLOZAPINE N-OXIDE

Product Name
CLOZAPINE N-OXIDE
CAS No.
34233-69-7
Chemical Name
CLOZAPINE N-OXIDE
Synonyms
CLOZAPINE N-OXIDE;Clozapine Impurity 16;Clozapine N-Oxide imp;Clozapine N-oxide (CNO);Clozapine N-oxide solution;Clozapine N-oxide Methanol Adduct;Clozapine N-oxide dihydrochloride NEW;Clozapine N-oxide (4-oxido-piprazinyl);Clozapine N-Oxide (1.0 mg/mL in Methanol);Clozapine N-oxide (4-oxido-piprazinyl) in methanol
CBNumber
CB4759216
Molecular Formula
C18H19ClN4O
Formula Weight
342.82
MOL File
34233-69-7.mol
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CLOZAPINE N-OXIDE Property

Melting point:
190-248°C
Flash point:
9℃
storage temp. 
-20°C Freezer, Under Inert Atmosphere
solubility 
Soluble in DMSO.
form 
powder
pka
6.86±0.20(Predicted)
color 
Yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey
OGUCZBIQSYYWEF-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn,T,F
Risk Statements 
22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements 
26-36-45-36/37-16-7
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
HP1760000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H336May cause drowsiness or dizziness

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C0832
Product name
Clozapine N-oxide
Packaging
5mg
Price
$232
Updated
2024/03/01
Alfa Aesar
Product number
J67235
Product name
Clozapine N-oxide, 99%
Packaging
5mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
16882
Product name
Clozapine N-oxide
Purity
≥98%
Packaging
1mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
16882
Product name
Clozapine N-oxide
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2304
Product name
Clozapine N-oxide hydrochloride
Purity
≥98% (HPLC), Water soluble Clozapine N-oxide
Packaging
5mg
Price
$225
Updated
2024/03/01
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CLOZAPINE N-OXIDE Chemical Properties,Usage,Production

Description

Clozapine-N-oxide (34233-69-7) is a clozapine?metabolite1?which is pharmacologically inert2. Agonist at human muscarinic designer receptors known as DREADDs, (designer receptors exclusively activated by designer drug).2?May be used to control grafted human pluripotent stem cell-derived neurons engineered to express DREADDs.3,4??Numerous other applications.5,6

Chemical Properties

Yellow Solid

Uses

Clozapine N-oxide has been used:

  • for the activation of human M4 muscarinic (hM4Di) in primary motor cortex
  • for inducing in vivo chemogenetic manipulation and impairing locomotor activity in Th-cre transgenic mice
  • in behavioral testing in mice and for stimulating (HEK293) cells

Uses

A 5-HT2 antagonist. A major metabolite of clozapine that can be monitored by HPLC. Possesses little or no activity towards serotonin receptors

Definition

ChEBI: Clozapine N-oxide is a dibenzodiazepine.

General Description

Clozapine N-oxide (CNO), inactive from of clozapine drug, activates G-protein-coupled receptors (GPCRs). CNO serves as a synthetic ligand for engineered human muscarinic receptor. It elicits clozapine-like effects upon metabolic conversion. Clozapine conversion to CNO favors its passage through blood-brain barrier.

Biochem/physiol Actions

5-HT2 serotonin receptor antagonist; major metabolite of clopazine that can be monitored by HPLC.

storage

Room temperature (desiccate)

References

1) Eiermann?et al.?(1997),?The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine; Br. J. Clin. Pharmacol.,?44?439 2) Armbruster?et al.?(2007),?Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand; Proc. Natl. Acad. Sci. USA,?104?5163 3) Chen?et al.?(2016),?Chemical Control of Grafted Human PSC-Derived Neurons in a Mouse Model of Parkinson’s Disease; Cell Stem Cell,?18?817 4) Vazey and Aston-Jones (2014),?Designer receptors: therapeutic adjuncts to cell replacement therapy in Parkinson’s disease: J. Clin. Invest.,?124?2858 5) Gomez?et al.?(2017)?Chemogenetics revealed: DREADD occupancy and activation via converted clozapine; Science?357?503 6) Marcinkiewcz?et al. (2016)?Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala; Nature?537?97

CLOZAPINE N-OXIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLOZAPINE N-OXIDE Suppliers

Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1637
Advantage
59
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
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View Lastest Price from CLOZAPINE N-OXIDE manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Clozapine Noxide 34233-69-7
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-07
Zhuozhou Wenxi import and Export Co., Ltd
Product
Clozapine N-oxide 34233-69-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Clozapine N-oxide 34233-69-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

34233-69-7, CLOZAPINE N-OXIDERelated Search:


  • e)(1,4)diazepine,8-chloro-11-(4-methyl-1-piperazinyl)-5h-dibenzo(n-oxide
  • CLOZAPINE N-OXIDE
  • 8-CHLORO-11-[4-METHYL-1-PIPERAZINYL]-5H-DIBENZO[B,E][1,4]DIAZEPINE N-OXIDE
  • MAJORMETABOLITEOFCLOZAPINE.POSSESSESLITTLEORNOACTIVITYAT5-HTRECEPTORS
  • Clozapine N-oxide Methanol Adduct
  • Clozapine N-oxide solution
  • Clozapine N-oxide (CNO)
  • 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine
  • Clozapine impurity 5/Clozapine N-Oxide/4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
  • Clozapine N-oxide dihydrochloride NEW
  • Clozapine N-Oxide (1.0 mg/mL in Methanol)
  • Clozapine N-oxide (4-oxido-piprazinyl)
  • 5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-
  • Clozapine N-OxideQ: What is Clozapine N-Oxide Q: What is the CAS Number of Clozapine N-Oxide Q: What is the storage condition of Clozapine N-Oxide Q: What are the applications of Clozapine N-Oxide
  • Clozapine Impurity 16
  • 3-Chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
  • Clozapine N-Oxide imp
  • 4-(8-Chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-methylpiperazine 1-oxide
  • Clozapine N-oxide (4-oxido-piprazinyl) in methanol
  • 34233-69-7
  • C18H19ClN4O2HCl
  • C18H19ClN4O
  • Various Metabolites and Impurities
  • Metabolites