6-Aminomethylquinoline
- Product Name
- 6-Aminomethylquinoline
- CAS No.
- 99071-54-2
- Chemical Name
- 6-Aminomethylquinoline
- Synonyms
- AKOS B016095;ART-CHEM-BB B016095;6-quinolylmethylamine;6-quinolylmethanamine;6-Quinolinemethanamine;6-Methylaminoquinoline;6-AMINOMETHYLQUINOLINE;QUINOLIN-6-YLMETHANAMINE;6-Quinoline methaneamine;QUINOLINE-6-YLMETHANAMINE
- CBNumber
- CB4768863
- Molecular Formula
- C10H10N2
- Formula Weight
- 158.2
- MOL File
- 99071-54-2.mol
6-Aminomethylquinoline Property
- Boiling point:
- 159°C/2mmHg(lit.)
- Density
- 1.156±0.06 g/cm3(Predicted)
- refractive index
- 1.6410-1.6450
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- Solid
- pka
- 8.68±0.30(Predicted)
- color
- Colorless to Yellow to Orange
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A2908
- Product name
- 6-(Aminomethyl)quinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $288
- Updated
- 2024/03/01
- Product number
- A2908
- Product name
- 6-(Aminomethyl)quinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 200mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- Q700555
- Product name
- 6-Quinolinemethanamine
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 43910
- Product name
- 6-(Aminomethyl)quinoline,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 200MG
- Price
- $94.75
- Updated
- 2021/12/16
- Product number
- 3H30-1-37
- Product name
- 6-Quinolinemethanamine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $152
- Updated
- 2021/12/16
6-Aminomethylquinoline Chemical Properties,Usage,Production
Uses
6-Quinolinemethanamine is a reagent in the synthesis of some novel 7-[(quinolin-6-yl)methyl] purines as potential c-Met inhibitors.
Synthesis
23395-72-4
99071-54-2
Step 5: Synthesis of quinolin-6-ylmethylamine To a saturated ammonia methanol solution (1 L) of quinoline-6-carbonitrile (96 g, 0.62 mol) was added Raney-Ni catalyst (10 g) and the reaction mixture was stirred at room temperature. The reaction was carried out for 16 hours at room temperature and 1 atmosphere of hydrogen at 1 atm. After completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 6-aminomethylquinoline as a brown oil (80 g, 82% yield). 1H-NMR (δ ppm, DMSO-d6, 400 MHz): δ 8.83 (dd, J = 4.2, 1.7 Hz, 1H), 8.29 (d, J = 8.3 Hz, 1H), 7.95 (d, J = 8.6 Hz, 1H), 7.85 (s, 1H), 7.75 (dd, J = 8.7, 1.8 Hz, 1H), 7.49 (dd, J = 8.2, 4.2 Hz, 1H), 3.90 (s, 2H).
References
[1] ChemSusChem, 2017, vol. 10, # 5, p. 842 - 846
[2] Patent: US2011/281865, 2011, A1. Location in patent: Page/Page column 83
[3] Patent: WO2011/145035, 2011, A1. Location in patent: Page/Page column 108
[4] Patent: WO2013/144737, 2013, A2. Location in patent: Paragraph 252
[5] Patent: US2015/57309, 2015, A1. Location in patent: Paragraph 0508
6-Aminomethylquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Aminomethylquinoline manufacturers
- Product
- 6-Aminomethylquinoline 99071-54-2
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22