ChemicalBook > CAS DataBase List > METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

Product Name: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
CAS No.: 39977-44-1
Chemical Name: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
Synonyms: Methyl 6-(hydroxymethyl);Methyl 6-(hydroxymethyl)picolinate;Methyl-6-hydroxymethyl-2-carboxylate;6-(hydroxymethyl)-2-pyridinecarboxylate;METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE;METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE;methyl 6-(hydroxymethyl)pyridine-2-carboxylate;Methyl 6-hydroxyMethyl-2-pyridine carboxylic acid;2-hydroxymethylpyridine-6-carboxylic acid methyl ester;6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester
CBNumber: CB4775911
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 39977-44-1.mol

Less

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Property

Melting point:: 178 °C
Boiling point:: 327.3±32.0 °C(Predicted)
Density: 1.244
storage temp.: Inert atmosphere,Room Temperature
pka: 13.03±0.10(Predicted)
form: Solid
color: White
InChI: InChI=1S/C8H9NO3/c1-12-8(11)7-4-2-3-6(5-10)9-7/h2-4,10H,5H2,1H3
InChIKey: DVIUNMLAPDJWHL-UHFFFAOYSA-N
SMILES: C1(C(OC)=O)=NC(CO)=CC=C1

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
HS Code: 2933399990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

TRC

Product number: M312835
Product name: Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate
Packaging: 1g
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: V5735
Product name: Methyl6-(hydroxymethyl)picolinate
Packaging: 5g
Price: $131
Updated: 2021/12/16

Oakwood

Product number: 214916
Product name: Methyl6-(hydroxymethyl)picolinate
Purity: 98%
Packaging: 100g
Price: $540
Updated: 2021/12/16

Matrix Scientific

Product number: 070838
Product name: Methyl 6-(hydroxymethyl)picolinate
Purity: 97%
Packaging: 5g
Price: $699
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0034773
Product name: METHYL-6-HYDROXYMETHYL-2-PYRIDINE CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $1518.83
Updated: 2021/12/16

Less

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

White or off-white solid

Uses

Methyl 6-(Hydroxymethyl)-2-pyridinecarboxylate is a chemical compound used in the synthesis of Losartan (L470500) derivatives as AT1 antagonists in the preparation of antihypertensive agents. Also used to prepare telomerase inhibitors for in vivo inhibitory activity.

Synthesis

Into a 100-mL round-bottom flask, was placed a solution of 2,6-dimethyl pyridine-2,6- dicarboxylate (950 mg, 4.87 mmol, 1.00 equiv) in a solvent mixture of methanol (33.2 mL) and dichloromethane (14.2 mL). NaB (185 mg, 5.02 mmol, 1.00 equiv) was added to the reaction mixture in several batches at 0°C. The resulting solution was stirred overnight at room temperature, and then it was quenched by the addition of 50 mL of NC1 (aq.). The resulting solution was extracted with 2x50 mL of dichloromethane and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 1-2: 1) as eluent to yield 750 mg (92%) of methyl 6-(hydroxymethyl)pyridine-2-carboxylate as a white solid.

References

[1] Patent: WO2013/102145, 2013, A1. Location in patent: Paragraph 0333
[2] Patent: US2015/344483, 2015, A1. Location in patent: Paragraph 0616; 0617
[3] Chemistry - A European Journal, 2017, vol. 23, # 21, p. 5154 - 5170
[4] Chemistry - A European Journal, 2006, vol. 12, # 24, p. 6393 - 6402
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 609 - 612

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Suppliers

China 140 India 2 United Kingdom 1 United States 21 Global 164

Zhenjiang Carbochem Pharmatech Co.,LTD

Tel: 0511-82018158 18136818960
Email: sales4@carbo-chem.com
Country: China
ProdList: 350
Advantage: 58

Tianjin Ji Ping Jia Chemical Co., Ltd.

Tel: 18622448868
Fax: 022-58620773
Email: jpjchem@163.com
Country: China
ProdList: 490
Advantage: 62

Suzhou Victorypharm Co.,Ltd.

Tel: 512-68242903 13916956214
Email: sales@victory-pharm.com
Country: China
ProdList: 1551
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Enantiotech Corporation Ltd

Tel: 760-85282375 13212762451
Email: marketing@enantiotech.net
Country: China
ProdList: 139
Advantage: 55

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Tetranov Biopharm

Tel: 13526569071
Email: sales@leadmedpharm.com
Country: China
ProdList: 7892
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

Record Tech (Shanghai) Co., LTD

Tel: 13761627472
Fax: 86-21-64965863
Email: 183009664@qq.com
Country: China
ProdList: 649
Advantage: 62

ChangZhou SIDU chemical Co., Ltd.

Tel: 0519-81291281 18015082300
Fax: 0519-81291281
Email: siduchem@hotmail.com
Country: China
ProdList: 274
Advantage: 62

Shanghai Litong Chemical Technology Co.,Ltd.

Tel: 13598610367 0373-7129549
Fax: 0373-8369699
Email: 2468833170@qq.com
Country: China
ProdList: 932
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Hubei XinyuanShun Chemical Co., Ltd.

Tel: 13971561712, 13995564702, 027-50664929
Fax: 027-50664927
Email: hbeixys2001@163.com
Country: China
ProdList: 3120
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9476
Advantage: 58

Suzhou Laing Biological Technology Co., LTD

Tel: 0512-62968256 18550502935
Fax: 0512-62968256
Email: export@laingbiotec.com
Country: China
ProdList: 976
Advantage: 58

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9979
Advantage: 58

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Shanghai KunRaise Chemical Technology Co., Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 716
Advantage: 55

Quzhou Rundong Chemical (Technology) Co.

Tel: 0570-8789886 18892685668
Fax: 0570-8789985
Email: info@rundongchemical.com
Country: China
ProdList: 4053
Advantage: 60

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Nanjing Huang Tai Pharmaceutical Technology Co. Ltd.

Tel: 025-58803135 18551845925
Fax: 025-58803650
Email: 3569572487@qq.com
Country: China
ProdList: 337
Advantage: 58

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Wuhan Chemwish Technology Co.， Ltd

Tel: 027-67849912
Fax: 027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 9148
Advantage: 60

Tianjin Wizard Science and Technology Co., Ltd.

Tel: 22-22-58620773 18102163693
Fax: 86-22-58620773
Email: tjchemwizard@163.com
Country: China
ProdList: 94
Advantage: 55

Chengdu DingDang Pharmaceutical Co., Ltd.

Tel: 028-86040038 13980902949;
Fax: 028-85149890
Email: market@dingdangchem.com
Country: China
ProdList: 1853
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai JingSi Biological Technology Co., Ltd

Tel: 18221840760
Fax: QQ:2990760589
Email: 2990760589@qq.com
Country: China
ProdList: 241
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 0-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 12475
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

JiangYin Ruisheng Chemical Co., Ltd.

Tel: 13003356808
Fax: QQ:1485751188
Email: 1485751188@qq.com
Country: China
ProdList: 403
Advantage: 55

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 9975
Advantage: 55

Adobe Chem Co., Ltd.

Tel: 2332782371
Fax: QQ: 2332782371
Email: adobechem@qq.com
Country: China
ProdList: 7980
Advantage: 58

LinkChem Technology Co., Ltd.

Tel: 021-58950110 13124863828
Fax: 021-20922272
Email: sales@linkchem.cn
Country: China
ProdList: 2998
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15394
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Shanghai ZiHao Pharmaceutical Co., Ltd.

Tel: 021-13482410-12 13482410112
Fax: -
Email: 362383684@qq.com
Country: China
ProdList: 737
Advantage: 58

Shanghai Time Chemicals CO., Ltd.

Tel: 021-57951555
Fax: 021-57951555
Email: tianshihuagong1111@163.com
Country: CHINA
ProdList: 1356
Advantage: 58

Suzhou Devi Pharma Technology Co., Ltd.

Tel: 0512-66565816 18651107528
Fax: 0512-66565816
Country: China
ProdList: 1040
Advantage: 58

Shanghai HongMin Pharmaceutical Co., Ltd.

Tel: 13651987816
Fax: -
Email: hongminpharm@163.com
Country: China
ProdList: 2326
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

3A Chemicals

Tel: 400-668-9898
Fax: 010-51582189
Email: service@3achem.com
Country: China
ProdList: 20557
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Less

View Lastest Price from METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Methyl 6-(hydroxymethyl)picolinate 39977-44-1
Price: US $1.10-9.90/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-08-14

Dideu Industries Group Limited

Product: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE 39977-44-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-30

Career Henan Chemical Co

Product: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE 39977-44-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

39977-44-1, METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINERelated Search:

6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER THIOSTREPTON dimethyl 4-chloropyridine-2,6-dicarboxylate Dimethyl 2,6-Pyridinedicarboxylate 2,6-Pyridinedicarboxylic acid monomethyl ester Diethyl 2,6-pyridinedicarboxylate METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE thiopeptin B Ethyl2,6-PyridinedicarboxylateMono siomycin [4,4'-BIPYRIDINE]-2,2',6,6'-TETRACARBOXYLIC ACID TETRAETHYL ESTER Diethyl 4-bromopyridine-2,6-dicarboxylate Dimethyl 2-bromo-2,6-pyridinedicarboxylate DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE 2,2',6,6'-TETRAKIS(METHOXYCARBONYL)-4,4'-BIPYRIDINE METHYL 4-CHLORO-6-(HYDROXYMETHYL)PICOLINATE Dimethyl 4-methoxy-2,6-Pyridinedicarboxylate 6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE

Methyl 6-(hydroxymethyl)picolinate

6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester

methyl 6-(hydroxymethyl)pyridine-2-carboxylate

Methyl 6-(hydroxymethyl)

Methyl-6-(hydroxymethyl)pyridine-2-carboxylate≥ 97% (GC)

Methyl-6-hydroxymethyl-2-carboxylate

Methyl 6-hydroxyMethyl-2-pyridine carboxylic acid

2-hydroxymethylpyridine-6-carboxylic acid methyl ester

6-(hydroxymethyl)-2-pyridinecarboxylic acid methyl ester

2-Pyridinecarboxylicacid, 6-(hydroxymethyl)-, methyl ester

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE ISO 9001：2015 REACH

6-(hydroxymethyl)-2-pyridinecarboxylate

39977-44-1

9977-44-1