METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

ChemicalBook > CAS DataBase List > METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

Product Name: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
CAS No.: 39977-44-1
Chemical Name: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
Synonyms: Methyl 6-(hydroxymethyl);Methyl 6-(hydroxymethyl)picolinate;Methyl-6-hydroxymethyl-2-carboxylate;METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE;METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE;methyl 6-(hydroxymethyl)pyridine-2-carboxylate;Methyl 6-hydroxyMethyl-2-pyridine carboxylic acid;2-hydroxymethylpyridine-6-carboxylic acid methyl ester;6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester;6-(hydroxymethyl)-2-pyridinecarboxylic acid methyl ester
CBNumber: CB4775911
Molecular Formula: C8H9NO3
Formula Weight: 167.16
MOL File: 39977-44-1.mol

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METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Property

Melting point:: 178 °C
Boiling point:: 327.3±32.0 °C(Predicted)
Density: 1.244
storage temp.: Inert atmosphere,Room Temperature
form: Solid
pka: 13.03±0.10(Predicted)
color: White

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: H63793
Product name: Methyl 6-(hydroxymethyl)pyridine-2-carboxylate, 95%
Packaging: 1g
Price: $135
Updated: 2024/03/01

Alfa Aesar

Product number: H63793
Product name: Methyl 6-(hydroxymethyl)pyridine-2-carboxylate, 95%
Packaging: 5g
Price: $462
Updated: 2021/12/16

Alfa Aesar

Product number: H63793
Product name: Methyl 6-(hydroxymethyl)pyridine-2-carboxylate, 95%
Packaging: 250mg
Price: $45.2
Updated: 2023/06/20

TRC

Product number: M312835
Product name: Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate
Packaging: 1g
Price: $165
Updated: 2021/12/16

Oakwood

Product number: 214916
Product name: Methyl6-(hydroxymethyl)picolinate
Purity: 98%
Packaging: 100g
Price: $540
Updated: 2021/12/16

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METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

White or off-white solid

Uses

Methyl 6-(Hydroxymethyl)-2-pyridinecarboxylate is a chemical compound used in the synthesis of Losartan (L470500) derivatives as AT1 antagonists in the preparation of antihypertensive agents. Also used to prepare telomerase inhibitors for in vivo inhibitory activity.

Synthesis

Into a 100-mL round-bottom flask, was placed a solution of 2,6-dimethyl pyridine-2,6- dicarboxylate (950 mg, 4.87 mmol, 1.00 equiv) in a solvent mixture of methanol (33.2 mL) and dichloromethane (14.2 mL). NaB (185 mg, 5.02 mmol, 1.00 equiv) was added to the reaction mixture in several batches at 0°C. The resulting solution was stirred overnight at room temperature, and then it was quenched by the addition of 50 mL of NC1 (aq.). The resulting solution was extracted with 2x50 mL of dichloromethane and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 1-2: 1) as eluent to yield 750 mg (92%) of methyl 6-(hydroxymethyl)pyridine-2-carboxylate as a white solid.

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE manufacturers

Dideu Industries Group Limited

Product: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE 39977-44-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-30

Shaanxi Dideu Medichem Co. Ltd

Product: methyl 6-(hydroxymethyl)picolinate 39977-44-1
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 1000 tons
Release date: 2019-12-26

Career Henan Chemical Co

Product: METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE 39977-44-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-11

39977-44-1, METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINERelated Search:

6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER THIOSTREPTON dimethyl 4-chloropyridine-2,6-dicarboxylate Dimethyl 2,6-Pyridinedicarboxylate 2,6-Pyridinedicarboxylic acid monomethyl ester Diethyl 2,6-pyridinedicarboxylate METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE thiopeptin B Ethyl2,6-PyridinedicarboxylateMono siomycin [4,4'-BIPYRIDINE]-2,2',6,6'-TETRACARBOXYLIC ACID TETRAETHYL ESTER Diethyl 4-bromopyridine-2,6-dicarboxylate Dimethyl 2-bromo-2,6-pyridinedicarboxylate DIETHYL 4-CHLORO-2,6-PYRIDINEDICARBOXYLATE 2,2',6,6'-TETRAKIS(METHOXYCARBONYL)-4,4'-BIPYRIDINE METHYL 4-CHLORO-6-(HYDROXYMETHYL)PICOLINATE Dimethyl 4-methoxy-2,6-Pyridinedicarboxylate 6-HYDROXYMETHYL-PYRIDINE-2-CARBOXYLIC ACID

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE

METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE

Methyl 6-(hydroxymethyl)picolinate

6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester

methyl 6-(hydroxymethyl)pyridine-2-carboxylate

Methyl 6-(hydroxymethyl)

Methyl-6-(hydroxymethyl)pyridine-2-carboxylate≥ 97% (GC)

Methyl-6-hydroxymethyl-2-carboxylate

Methyl 6-hydroxyMethyl-2-pyridine carboxylic acid

2-hydroxymethylpyridine-6-carboxylic acid methyl ester

6-(hydroxymethyl)-2-pyridinecarboxylic acid methyl ester

2-Pyridinecarboxylicacid, 6-(hydroxymethyl)-, methyl ester

METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE ISO 9001：2015 REACH

39977-44-1

9977-44-1