dimethyl 4-chloropyridine-2,6-dicarboxylate
- Product Name
- dimethyl 4-chloropyridine-2,6-dicarboxylate
- CAS No.
- 5371-70-0
- Chemical Name
- dimethyl 4-chloropyridine-2,6-dicarboxylate
- Synonyms
- NSC 41773;2,6-Bis(carbomethoxy)-4-chloropyridine;Methyl 4-chloropyridine-2,6-dicarboxylate;2,6-diMethyl 4-chloropyridine-2,6-dicarboxylate;Dimethyl 4-Chloropyridine-2,6-Dicarboxylate,>98%;Dimethyl 4-chloropyridine-2,6-dicarboxylate ,97%;4-Chloro-2,6-pyridinedicarboxylic acid dimethyl ester;4-Chloro-2,6-pyridinedicarboxylic acid 2,6-dimethyl ester;2,6-Pyridinedicarboxylic acid, 4-chloro-, 2,6-dimethyl ester;dimethyl 4-chloropyridine-2,6-dicarboxylate ISO 9001：2015 REACH
- CBNumber
- CB41259216
- Molecular Formula
- C9H8ClNO4
- Formula Weight
- 229.62
- MOL File
- 5371-70-0.mol
dimethyl 4-chloropyridine-2,6-dicarboxylate Property
- Melting point:
- 168℃
- Boiling point:
- 355℃
- Density
- 1.347
- Flash point:
- 169℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Solid
- pka
- -2.40±0.10(Predicted)
- color
- Pale yellow
- Water Solubility
- Slightly soluble in water.
Safety
- Risk Statements
- 20/21/22
- Safety Statements
- 24/25-36/37
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D4693
- Product name
- Dimethyl 4-Chloro-2,6-pyridinedicarboxylate
- Purity
- >98.0%(GC)(N)
- Packaging
- 1g
- Price
- $96
- Updated
- 2025/07/31
- Product number
- FD133459
- Product name
- Dimethyl 4-chloropyridine-2,6-dicarboxylate
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 091910
- Product name
- Dimethyl4-chloropyridine-2,6-dicarboxylate
- Purity
- 98%
- Packaging
- 250mg
- Price
- $10
- Updated
- 2021/12/16
- Product number
- FD133459
- Product name
- Dimethyl 4-chloropyridine-2,6-dicarboxylate
- Packaging
- 2g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FD133459
- Product name
- Dimethyl 4-chloropyridine-2,6-dicarboxylate
- Packaging
- 5G
- Price
- $125
- Updated
- 2021/12/16
dimethyl 4-chloropyridine-2,6-dicarboxylate Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field
Synthesis
67-56-1
138-60-3
5371-70-0
The general procedure for the synthesis of methyl 4-chloro-2,6-dipyridinecarboxylate from methanol and 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid was as follows: phosphorus pentachloride (PCl5, 11.8 g, 56.8 mmol) was slowly added to chloroform containing 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid (2.5 g, 13.8 mmol) ( CHCl3, 30 mL) solution. The reaction mixture was refluxed for 3 days. Upon completion of the reaction, it was cooled to 0°C and methanol (MeOH) was added dropwise until gas escape ceased. Subsequently, the solution was stirred at room temperature for 2 hours and then concentrated. To the concentrate, saturated aqueous sodium bicarbonate (NaHCO3) was added and the pH was adjusted to 7. The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and the solvent was evaporated under vacuum. The residue was purified by column chromatography (eluent: cyclohexane/ethyl acetate, 8:2) to afford the target product methyl 4-chloro-2,6-dipyridinecarboxylate (2.57 g, 93% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3).
References
[1] Tetrahedron, 2015, vol. 71, # 33, p. 5321 - 5336
[2] Chemistry - An Asian Journal, 2013, vol. 8, # 11, p. 2685 - 2690
[3] Patent: US2015/361116, 2015, A1. Location in patent: Paragraph 0171
[4] Journal of Organic Chemistry, 2003, vol. 68, # 7, p. 2741 - 2747
[5] Tetrahedron Letters, 1986, vol. 27, # 31, p. 3635 - 3638
dimethyl 4-chloropyridine-2,6-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from dimethyl 4-chloropyridine-2,6-dicarboxylate manufacturers
- Product
- dimethyl 4-chloropyridine-2,6-dicarboxylate 5371-70-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-06
- Product
- dimethyl 4-chloropyridine-2,6-dicarboxylate 5371-70-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 100KG
- Release date
- 2019-08-29