4-CHLOROPICOLINALDEHYDE
- Product Name
- 4-CHLOROPICOLINALDEHYDE
- CAS No.
- 63071-13-6
- Chemical Name
- 4-CHLOROPICOLINALDEHYDE
- Synonyms
- oropyridine-2-carbaL;4-Chloropicolaldehyde;4-CHLOROPICOLINALDEHYDE;Picolinaldehyde, 4-chloro-;4-Chloro-2-aldehyde pyridine;4-chloropyridine-2-carbaldehyde;4-chloro-2-pyridinecarbaldehyde;4-CHLOROPYRIDINE-2-CARBOXALDEHYDE;4-Chloro-2-pyridinecarboxaldehyde;2-Pyridinecarboxaldehyde,4-chloro-
- CBNumber
- CB6782472
- Molecular Formula
- C6H4ClNO
- Formula Weight
- 141.56
- MOL File
- 63071-13-6.mol
4-CHLOROPICOLINALDEHYDE Property
- Melting point:
- 32-34°
- Boiling point:
- 206℃
- Density
- 1.332
- Flash point:
- 79℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 1.78±0.10(Predicted)
- color
- Off-White to Pale Yellow
- Stability:
- Air Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C380345
- Product name
- 4-Chloro-2-pyridinecarboxaldehyde
- Packaging
- 5g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- OR303780
- Product name
- 4-Chloro-2-pyridinecarbaldehyde
- Purity
- 97%
- Packaging
- 25g
- Price
- $290
- Updated
- 2021/12/16
- Product number
- 048191
- Product name
- 4-Chloro-2-pyridinecarbaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $298
- Updated
- 2021/12/16
- Product number
- FC32275
- Product name
- 4-Chloro-2-pyridinecarbaldehyde
- Packaging
- 25g
- Price
- $390
- Updated
- 2021/12/16
- Product number
- 4H56-5-0A
- Product name
- 4-Chloro-2-pyridinecarbaldehyde
- Packaging
- 25g
- Price
- $600
- Updated
- 2021/12/16
4-CHLOROPICOLINALDEHYDE Chemical Properties,Usage,Production
Uses
4-Chloro-2-pyridinecarboxaldehyde is a useful synthetic intermediate. It is used in the synthesis of 2,2''-bipyridines, (chloropyridyl)(pyridyl)ethylamine and aryl and heteroaryl fluoromethyl ketones.
Synthesis
24484-93-3
63071-13-6
General procedure for the synthesis of 4-chloro-2-pyridinecarboxaldehyde from methyl 4-chloropyridinecarboxylate: to a solution of methyl 4-chloropyridinecarboxylate (2.5 g, 14.6 mmol) in anhydrous THF (100 mL) was added slowly and dropwise diisobutylaluminum hydride (1.0 M solution in THF, 29.1 mmol) at -78 °C and the reaction was stirred in an argon atmosphere at that temperature mixture for 2 hours. Upon completion of the reaction, the reaction was quenched with methanol (MeOH) at -78 °C, followed by the addition of potassium sodium tartrate solution (1.0 M, 180 mL), and the mixture was stirred and gradually warmed to room temperature over a period of 1 hour. The reaction mixture was diluted with ethyl acetate (EtOAc, 60 mL) and the organic layer was separated, washed with saturated saline and dried with anhydrous sodium sulfate. The solvent was removed by mild decompression distillation at room temperature to afford the target product 4-chloro-2-pyridinecarboxaldehyde (1.87 g, 91% yield), which solidified to light yellow crystals after standing at room temperature.
References
[1] Patent: US2004/186114, 2004, A1. Location in patent: Page/Page column 69; 70
[2] Patent: EP1897880, 2008, A1. Location in patent: Page/Page column 16
[3] Inorganic Chemistry, 2013, vol. 52, # 11, p. 6481 - 6501
[4] Bulletin of the Chemical Society of Japan, 2015, vol. 88, # 6, p. 784 - 791
4-CHLOROPICOLINALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-CHLOROPICOLINALDEHYDE Suppliers
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 0519-89803565 13776850645
- Fax
- 0519-89803575
- info4@huanlingchem.com
- Country
- China
- ProdList
- 891
- Advantage
- 68
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 28-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 510
- Advantage
- 57
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 510-83782303 13771177691
- Fax
- 0510- 8378-9906
- sales@itppharm.com
- Country
- China
- ProdList
- 110
- Advantage
- 62
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
View Lastest Price from 4-CHLOROPICOLINALDEHYDE manufacturers
- Product
- 4-CHLOROPICOLINALDEHYDE 63071-13-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98% Min
- Supply Ability
- 1000kg
- Release date
- 2023-03-18
- Product
- 4-CHLOROPICOLINALDEHYDE 63071-13-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-28
- Product
- 4-CHLOROPICOLINALDEHYDE 63071-13-6
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-01-08