4-Chloropyridine-2-carboxylic acid

Product Name: 4-Chloropyridine-2-carboxylic acid
CAS No.: 5470-22-4
Chemical Name: 4-Chloropyridine-2-carboxylic acid
Synonyms: 4-CHLOROPICOLINIC ACID;4-chloropicolinic;Chloropicolinicacid;IFLAB-BB F1926-0017;4-ChloropicolinicAci;Sorafenib Impurity 03;4-chloro-2-picolinic acid;4-CHLOROPICOLINIC ACID 99%;4-Chloropicolinic acid ,98%;4-Chloropicolinic acid, 97.5%
CBNumber: CB7353077
Molecular Formula: C6H4ClNO2
Formula Weight: 157.55
MOL File: 5470-22-4.mol

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4-Chloropyridine-2-carboxylic acid Property

Melting point:: 181°C
Boiling point:: 308.0±22.0 °C(Predicted)
Density: 1.470±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.27±0.10(Predicted)
form: powder to crystal
color: White to Almost white
InChI: InChI=1S/C6H4ClNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10)
InChIKey: NNMYRMGMVLMQAY-UHFFFAOYSA-N
SMILES: C1(C(O)=O)=NC=CC(Cl)=C1
CAS DataBase Reference: 5470-22-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
Hazard Note: Harmful/Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS000043
Product name: 4-Chloro-2-pyridinecarboxylic acid
Purity: AldrichCPR
Packaging: 100MG
Price: $73.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: ADE000290
Product name: 4-Chloro-pyridine-2-carboxylic acid
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TCI Chemical

Product number: C1360
Product name: 4-Chloro-2-pyridinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: C1360
Product name: 4-Chloro-2-pyridinecarboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $225
Updated: 2025/07/31

TRC

Product number: C370955
Product name: 4-ChloropicolinicAcid
Packaging: 5g
Price: $195
Updated: 2021/12/16

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4-Chloropyridine-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-Chloropicolinic Acid is a reactant used in the synthesis of VU0431316, a negative allosteric modulator of mGlu5.

Synthesis

98-98-6

5470-22-4

General procedure for the synthesis of 4-chloropyridine-2-carboxylic acid from 2-pyridinecarboxylic acid: a suspension of 2-pyridinecarboxylic acid (0.79 g, 6.35 mmol) and sodium bromide (1.30 g, 12.7 mmol) in 10 mL of thionyl chloride was heated for 20 hr under mild reflux conditions. During the reaction, the initial dark green color of the mixture gradually changed to a deep red color. Upon completion of the reaction, the excess thionyl chloride was removed by rotary evaporation, and the resulting orange residue was dissolved in about 15 mL of dichloromethane and filtered through diatomaceous earth to remove insoluble impurities. The orange filtrate was cooled to -2°C and 20 mL of double-distilled water was slowly added under vigorous stirring while maintaining the reaction temperature between -2 and 2°C. At this point, the color of the solution changed to light orange and a white precipitate was produced. Subsequently, the mixture was continued to be stirred at room temperature for 20 hours. Afterwards, dichloromethane and water were removed by rotary evaporation. Finally, the solid product was recrystallized from a minimal amount of ethanol to give 0.28 g (28% yield) of 4-chloropyridine-2-carboxylic acid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ= 8.72 (1H, d, J = 4.9 Hz), 8.09 (1H, d, J = 1.6 Hz), 7.84 (1H, dd, J = 4.9, 1.6 Hz).

References

[1] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 48-49
[2] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 48-49
[3] Synthetic Communications, 1996, vol. 26, # 10, p. 2017 - 2025
[4] Patent: US2006/160803, 2006, A1. Location in patent: Page/Page column 136
[5] Patent: EP1650194, 2006, A1. Location in patent: Page/Page column 37

4-Chloropyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 2-Picoline 2-Methyl-4-nitropyridine Hydrogen peroxide Hydrochloric acid Nitric acid Potassium permanganate Acetic acid Sodium carbonate

Preparation Products

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4-Chloropyridine-2-carboxylic acid Suppliers

Americas 1 Australia 1 Belgium 2 Canada 2 China 284 Europe 1 France 3 Germany 7 India 20 Japan 2 Switzerland 3 The Netherlands 2 Ukraine 2 United Kingdom 13 United States 46 Global 389

NanJing Xienuo bio Co.,Ltd.

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View Lastest Price from 4-Chloropyridine-2-carboxylic acid manufacturers

Dideu Industries Group Limited

Product: 4-Chloropyridine-2-carboxylic acid 5470-22-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-22

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Chloropyridine-2-carboxylic acid 5470-22-4
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 4-Chloropyridine-2-carboxylic acid 5470-22-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-21

5470-22-4, 4-Chloropyridine-2-carboxylic acidRelated Search:

Zinc picolinate 3-Chloroperoxybenzoic acid Chromium picolinate 2-Picolinic acid 2-Chloro-3-cyanopyridine Benzyl chloroformate 4-Methoxy-1H-indole-2-carboxylic acid 4-Methoxyphenylboronic acid 4-(METHOXYCARBONYL)PHENYLBORONIC ACID (4-CHLORO-PYRIDIN-2-YL)-METHANOL Methyl 4-chloro-2-pyridinecarboxylate hydrochloride Methyl chloroformate Ethyl chloroformate Methyl 4-chloropicolinate 3,4,5-Trichloropyridine-2-carboxylic acid Tetrachloropyridine-2-carboxylic acid 6-CHLOROPYRIDINE-3-CARBOXYLIC ACID,6-Chloronicotinic acid, 6-Chloropyridine-3-carboxylic acid dimethyl 4-chloropyridine-2,6-dicarboxylate

IFLAB-BB F1926-0017

4-CHLOROPICOLINIC ACID

4-CHLOROPYRIDINE-2-CARBOXYLIC ACID

4-CHLORO-2-PYRIDINECARBOXYLIC ACID

4-Chloropyridine-2-carboxylic

Chloropicolinicacid

4-CHLOROPICOLINIC ACID 99%

4-Chloropicolinic acid ,98%

4-chloropicolinic

4-Chloropicolinic acid, 2-Carboxy-4-chloropyridine

4-Chloropicolinic acid, 97.5%

4-chloro-2-picolinic acid

4-Chloropyridine-2-carboxylicacid,94%

2-Pyridinecarboxylicacid, 4-chloro-

4-Chloro-2-pyridinecarboxylic Acid &gt

4-Chloropyridine-2-carboxylic acid ISO 9001：2015 REACH

Sorafenib tosylate Impurity U

-Chloropyridine-2-carboxylic acid

4-ChloropicolinicAci

Sorafenib Impurity 03

4-Chloropyridin-2-carboxylic acid

5470-22-4

5770-22-4

25470-22-4

Chloropyridines

Halopyridines

Chloropyridines

Halopyridines

Carboxylic Acids

Pyridine

pharmacetical

Carboxylic Acids

blocks

Carboxes

Pyridines

Pyridine series

Acids and Derivatives

Heterocycles