ChemicalBook > CAS DataBase List > 4-Chloropyridine-2-carboxylic acid

4-Chloropyridine-2-carboxylic acid

Product Name
4-Chloropyridine-2-carboxylic acid
CAS No.
5470-22-4
Chemical Name
4-Chloropyridine-2-carboxylic acid
Synonyms
4-CHLOROPICOLINIC ACID;4-chloropicolinic;Chloropicolinicacid;IFLAB-BB F1926-0017;4-ChloropicolinicAci;Sorafenib Impurity 03;4-chloro-2-picolinic acid;4-CHLOROPICOLINIC ACID 99%;4-Chloropicolinic acid ,98%;4-Chloropicolinic acid, 97.5%
CBNumber
CB7353077
Molecular Formula
C6H4ClNO2
Formula Weight
157.55
MOL File
5470-22-4.mol
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4-Chloropyridine-2-carboxylic acid Property

Melting point:
181°C
Boiling point:
308.0±22.0 °C(Predicted)
Density 
1.470±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
pka
3.27±0.10(Predicted)
form 
powder to crystal
color 
White to Almost white
InChI
InChI=1S/C6H4ClNO2/c7-4-1-2-8-5(3-4)6(9)10/h1-3H,(H,9,10)
InChIKey
NNMYRMGMVLMQAY-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=NC=CC(Cl)=C1
CAS DataBase Reference
5470-22-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Harmful/Irritant/Keep Cold
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS000043
Product name
4-Chloro-2-pyridinecarboxylic acid
Purity
AldrichCPR
Packaging
100MG
Price
$73.1
Updated
2025/07/31
Sigma-Aldrich
Product number
ADE000290
Product name
4-Chloro-pyridine-2-carboxylic acid
Purity
Aldrich
Packaging
1g
Price
$216
Updated
2025/07/31
TCI Chemical
Product number
C1360
Product name
4-Chloro-2-pyridinecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$69
Updated
2025/07/31
TCI Chemical
Product number
C1360
Product name
4-Chloro-2-pyridinecarboxylic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$225
Updated
2025/07/31
TRC
Product number
C370955
Product name
4-ChloropicolinicAcid
Packaging
5g
Price
$195
Updated
2021/12/16
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4-Chloropyridine-2-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

4-Chloropicolinic Acid is a reactant used in the synthesis of VU0431316, a negative allosteric modulator of mGlu5.

Synthesis

98-98-6

5470-22-4

General procedure for the synthesis of 4-chloropyridine-2-carboxylic acid from 2-pyridinecarboxylic acid: a suspension of 2-pyridinecarboxylic acid (0.79 g, 6.35 mmol) and sodium bromide (1.30 g, 12.7 mmol) in 10 mL of thionyl chloride was heated for 20 hr under mild reflux conditions. During the reaction, the initial dark green color of the mixture gradually changed to a deep red color. Upon completion of the reaction, the excess thionyl chloride was removed by rotary evaporation, and the resulting orange residue was dissolved in about 15 mL of dichloromethane and filtered through diatomaceous earth to remove insoluble impurities. The orange filtrate was cooled to -2°C and 20 mL of double-distilled water was slowly added under vigorous stirring while maintaining the reaction temperature between -2 and 2°C. At this point, the color of the solution changed to light orange and a white precipitate was produced. Subsequently, the mixture was continued to be stirred at room temperature for 20 hours. Afterwards, dichloromethane and water were removed by rotary evaporation. Finally, the solid product was recrystallized from a minimal amount of ethanol to give 0.28 g (28% yield) of 4-chloropyridine-2-carboxylic acid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ= 8.72 (1H, d, J = 4.9 Hz), 8.09 (1H, d, J = 1.6 Hz), 7.84 (1H, dd, J = 4.9, 1.6 Hz).

References

[1] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 48-49
[2] Patent: WO2008/17855, 2008, A1. Location in patent: Page/Page column 48-49
[3] Synthetic Communications, 1996, vol. 26, # 10, p. 2017 - 2025
[4] Patent: US2006/160803, 2006, A1. Location in patent: Page/Page column 136
[5] Patent: EP1650194, 2006, A1. Location in patent: Page/Page column 37

4-Chloropyridine-2-carboxylic acid Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 2-Picoline 2-Methyl-4-nitropyridine Hydrogen peroxide Hydrochloric acid Nitric acid Potassium permanganate Acetic acid Sodium carbonate

Preparation Products

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4-Chloropyridine-2-carboxylic acid Suppliers

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View Lastest Price from 4-Chloropyridine-2-carboxylic acid manufacturers

Dideu Industries Group Limited
Product
4-Chloropyridine-2-carboxylic acid 5470-22-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-22
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Chloropyridine-2-carboxylic acid 5470-22-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4-Chloropyridine-2-carboxylic acid 5470-22-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customized
Release date
2019-06-21

5470-22-4, 4-Chloropyridine-2-carboxylic acidRelated Search:

Zinc picolinate 3-Chloroperoxybenzoic acid Chromium picolinate 2-Picolinic acid 2-Chloro-3-cyanopyridine Benzyl chloroformate 4-Methoxy-1H-indole-2-carboxylic acid 4-Methoxyphenylboronic acid 4-(METHOXYCARBONYL)PHENYLBORONIC ACID (4-CHLORO-PYRIDIN-2-YL)-METHANOL Methyl 4-chloro-2-pyridinecarboxylate hydrochloride Methyl chloroformate Ethyl chloroformate Methyl 4-chloropicolinate 3,4,5-Trichloropyridine-2-carboxylic acid Tetrachloropyridine-2-carboxylic acid 6-CHLOROPYRIDINE-3-CARBOXYLIC ACID,6-Chloronicotinic acid, 6-Chloropyridine-3-carboxylic acid dimethyl 4-chloropyridine-2,6-dicarboxylate

  • IFLAB-BB F1926-0017
  • 4-CHLOROPICOLINIC ACID
  • 4-CHLOROPYRIDINE-2-CARBOXYLIC ACID
  • 4-CHLORO-2-PYRIDINECARBOXYLIC ACID
  • 4-Chloropyridine-2-carboxylic
  • Chloropicolinicacid
  • 4-CHLOROPICOLINIC ACID 99%
  • 4-Chloropicolinic acid ,98%
  • 4-chloropicolinic
  • 4-Chloropicolinic acid, 2-Carboxy-4-chloropyridine
  • 4-Chloropicolinic acid, 97.5%
  • 4-chloro-2-picolinic acid
  • 4-Chloropyridine-2-carboxylicacid,94%
  • 2-Pyridinecarboxylicacid, 4-chloro-
  • 4-Chloro-2-pyridinecarboxylic Acid &gt
  • 4-Chloropyridine-2-carboxylic acid ISO 9001：2015 REACH
  • Sorafenib tosylate Impurity U
  • -Chloropyridine-2-carboxylic acid
  • 4-ChloropicolinicAci
  • Sorafenib Impurity 03
  • 4-Chloropyridin-2-carboxylic acid
  • 5470-22-4
  • 5770-22-4
  • 25470-22-4
  • Chloropyridines
  • Halopyridines
  • Chloropyridines
  • Halopyridines
  • Carboxylic Acids
  • Pyridine
  • pharmacetical
  • Carboxylic Acids
  • blocks
  • Carboxes
  • Pyridines
  • Pyridine series
  • Acids and Derivatives
  • Heterocycles