ChemicalBook > CAS DataBase List > dimethyl 4-chloropyridine-2,6-dicarboxylate

dimethyl 4-chloropyridine-2,6-dicarboxylate

Product Name: dimethyl 4-chloropyridine-2,6-dicarboxylate
CAS No.: 5371-70-0
Chemical Name: dimethyl 4-chloropyridine-2,6-dicarboxylate
Synonyms: NSC 41773;2,6-Bis(carbomethoxy)-4-chloropyridine;Methyl 4-chloropyridine-2,6-dicarboxylate;2,6-diMethyl 4-chloropyridine-2,6-dicarboxylate;Dimethyl 4-Chloropyridine-2,6-Dicarboxylate,>98%;Dimethyl 4-chloropyridine-2,6-dicarboxylate ,97%;4-Chloro-2,6-pyridinedicarboxylic acid dimethyl ester;4-Chloro-2,6-pyridinedicarboxylic acid 2,6-dimethyl ester;2,6-Pyridinedicarboxylic acid, 4-chloro-, 2,6-dimethyl ester;dimethyl 4-chloropyridine-2,6-dicarboxylate ISO 9001：2015 REACH
CBNumber: CB41259216
Molecular Formula: C9H8ClNO4
Formula Weight: 229.62
MOL File: 5371-70-0.mol

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dimethyl 4-chloropyridine-2,6-dicarboxylate Property

Melting point:: 168℃
Boiling point:: 355℃
Density: 1.347
Flash point:: 169℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Solid
pka: -2.40±0.10(Predicted)
color: Pale yellow
Water Solubility: Slightly soluble in water.

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Safety

Risk Statements: 20/21/22
Safety Statements: 24/25-36/37
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4693
Product name: Dimethyl 4-Chloro-2,6-pyridinedicarboxylate
Purity: >98.0%(GC)(N)
Packaging: 1g
Price: $96
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FD133459
Product name: Dimethyl 4-chloropyridine-2,6-dicarboxylate
Packaging: 1g
Price: $40
Updated: 2021/12/16

Oakwood

Product number: 091910
Product name: Dimethyl4-chloropyridine-2,6-dicarboxylate
Purity: 98%
Packaging: 250mg
Price: $10
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD133459
Product name: Dimethyl 4-chloropyridine-2,6-dicarboxylate
Packaging: 2g
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD133459
Product name: Dimethyl 4-chloropyridine-2,6-dicarboxylate
Packaging: 5G
Price: $125
Updated: 2021/12/16

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dimethyl 4-chloropyridine-2,6-dicarboxylate Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field

Synthesis

67-56-1

138-60-3

5371-70-0

The general procedure for the synthesis of methyl 4-chloro-2,6-dipyridinecarboxylate from methanol and 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid was as follows: phosphorus pentachloride (PCl5, 11.8 g, 56.8 mmol) was slowly added to chloroform containing 4-oxo-1,4-dihydro-2,6-pyridinedicarboxylic acid (2.5 g, 13.8 mmol) ( CHCl3, 30 mL) solution. The reaction mixture was refluxed for 3 days. Upon completion of the reaction, it was cooled to 0°C and methanol (MeOH) was added dropwise until gas escape ceased. Subsequently, the solution was stirred at room temperature for 2 hours and then concentrated. To the concentrate, saturated aqueous sodium bicarbonate (NaHCO3) was added and the pH was adjusted to 7. The organic layer was separated, dried over anhydrous sodium sulfate (Na2SO4), filtered and the solvent was evaporated under vacuum. The residue was purified by column chromatography (eluent: cyclohexane/ethyl acetate, 8:2) to afford the target product methyl 4-chloro-2,6-dipyridinecarboxylate (2.57 g, 93% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (100 MHz, CDCl3).

References

[1] Tetrahedron, 2015, vol. 71, # 33, p. 5321 - 5336
[2] Chemistry - An Asian Journal, 2013, vol. 8, # 11, p. 2685 - 2690
[3] Patent: US2015/361116, 2015, A1. Location in patent: Paragraph 0171
[4] Journal of Organic Chemistry, 2003, vol. 68, # 7, p. 2741 - 2747
[5] Tetrahedron Letters, 1986, vol. 27, # 31, p. 3635 - 3638

dimethyl 4-chloropyridine-2,6-dicarboxylate Preparation Products And Raw materials

Raw materials

Diethyl oxalate Sodium Phosphorus pentachloride Chlorobenzene

Preparation Products

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View Lastest Price from dimethyl 4-chloropyridine-2,6-dicarboxylate manufacturers

Dideu Industries Group Limited

Product: dimethyl 4-chloropyridine-2,6-dicarboxylate 5371-70-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-06

Career Henan Chemical Co

Product: dimethyl 4-chloropyridine-2,6-dicarboxylate 5371-70-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100KG
Release date: 2019-08-29

5371-70-0, dimethyl 4-chloropyridine-2,6-dicarboxylateRelated Search:

6-Methyl-2-pyridinecarboxylic acid 4-Chloropyridine-2-carboxylic acid 2,6-Pyridinedicarboxylic acid monomethyl ester Dimethyl 2,6-Pyridinedicarboxylate (4-CHLORO-PYRIDIN-2-YL)-METHANOL Pyridine-2,6-dicarboxylic acid Methyl 4-chloropicolinate 4-CHLOROPICOLINALDEHYDE dimethyl 4-chloropyridine-2,6-dicarboxylate 4-Chloro-2,6-dimethylpyridine 4-CHLORO-PYRIDINE-2,6-DICARBOXYLIC ACID 4-Chloro-6-methylpyridine-2-carboxylic acid (4-CHLORO-6-METHYL-PYRIDIN-2-YL)-METHANOL Di-tert.-butyl 4-chloro-2,6-pyridinedicarboxylate 6-FORMYL-2-PYRIDINE CARBOXYLIC ACID METHYL ESTER METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE methyl 6-methylpyridine-2-carboxylate METHYL 4-CHLORO-6-(HYDROXYMETHYL)PICOLINATE

Dimethyl 4-chloropyridine-2,6-dicarboxylate ,97%

2,6-diMethyl 4-chloropyridine-2,6-dicarboxylate

2,6-Bis(carbomethoxy)-4-chloropyridine

4-Chloro-2,6-pyridinedicarboxylic acid 2,6-dimethyl ester

4-Chloro-2,6-pyridinedicarboxylic acid dimethyl ester

NSC 41773

Methyl 4-chloropyridine-2,6-dicarboxylate

Dimethyl 4-Chloropyridine-2,6-Dicarboxylate,>98%

2,6-Pyridinedicarboxylic acid, 4-chloro-, 2,6-dimethyl ester

dimethyl 4-chloropyridine-2,6-dicarboxylate ISO 9001：2015 REACH

5371-70-0