ChemicalBook > CAS DataBase List > N-(tert-Butoxycarbonyl)-L-phenylalanine

N-(tert-Butoxycarbonyl)-L-phenylalanine

Product Name
N-(tert-Butoxycarbonyl)-L-phenylalanine
CAS No.
13734-34-4
Chemical Name
N-(tert-Butoxycarbonyl)-L-phenylalanine
Synonyms
BOC-PHE-OH;BOC-PHE;BOC-L-PHE-OH;BOC-L-PHE;BOC-L-PHENYLALANINE;N-BOC-L-PHENYLALANINE;BOC-PHENYLALANINE;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-;BOC-ph-OH;BOC Phenly Alanine
CBNumber
CB4781305
Molecular Formula
C14H19NO4
Formula Weight
265.3
MOL File
13734-34-4.mol
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N-(tert-Butoxycarbonyl)-L-phenylalanine Property

Melting point:
85-87 °C(lit.)
Boiling point:
408.52°C (rough estimate)
Density 
1.1356 (rough estimate)
refractive index 
24.5 ° (C=1, EtOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Soluble in methanol, dichloromethane, dimethylformamide and N-methyl-2-pyrrolidone.
pka
3.88±0.10(Predicted)
form 
Fine Crystalline Powder
color 
White
optical activity
[α]20/D +25±1°, c = 1% in ethanol
BRN 
2219729
InChI
InChI=1S/C14H19NO4/c1-14(2,3)19-13(18)15-11(12(16)17)9-10-7-5-4-6-8-10/h4-8,11H,9H2,1-3H3,(H,15,18)(H,16,17)/t11-/m0/s1
InChIKey
ZYJPUMXJBDHSIF-NSHDSACASA-N
SMILES
C(O)(=O)[C@H](CC1=CC=CC=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference
13734-34-4(CAS DataBase Reference)
EPA Substance Registry System
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- (13734-34-4)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36-22-36/37/38-20/21/22
Safety Statements 
39-26-36-24/25
WGK Germany 
3
TSCA 
Yes
HS Code 
29242990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53006
Product name
Boc-Phe-OH
Purity
Novabiochem?
Packaging
25g
Price
$57.6
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53006
Product name
Boc-Phe-OH
Purity
Novabiochem?
Packaging
100g
Price
$66
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53006
Product name
Boc-Phe-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$1290
Updated
2025/07/31
Sigma-Aldrich
Product number
8.53006
Product name
Boc-Phe-OH
Purity
Novabiochem<SUP>&#174;</SUP>
Packaging
1 kg
Price
$1290
Updated
2025/07/31
Sigma-Aldrich
Product number
15480
Product name
Boc-Phe-OH
Purity
≥99.0% (T)
Packaging
5g
Price
$40.4
Updated
2025/07/31
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N-(tert-Butoxycarbonyl)-L-phenylalanine Chemical Properties,Usage,Production

Chemical Properties

N-(tert-Butoxycarbonyl)-L-phenylalanine is white fine crystalline powder

Uses

N-Boc-L-phenylalanine is a derivative of Phenylalanine used in enantioselective hydrolysis of amino acid esters.

Uses

N-(tert-Butoxycarbonyl)-L-phenylalanine is used in enantioselective hydrolysis of amino acid esters. Acts as an inhibitor of gastric acid secretion.

Preparation

Sodium hydroxide (4.4 g, 0.11 mol) was placed in a flask, and dissolved in water (110 mL). Phenylalanine (16.5 g, 0.1 mol) was added, the suspension was stirred until a solution was obtained, and then tert-butanol (75 mL) was added. Boc2O (22.3 g, 0.12 mol) was then added with stirring over a period of 1 h, keeping the mixture near 0 ℃. A white precipitate was produced, and at the end of the addition the pH had dropped to 7.5–8.5. The mixture was then carefully acidified by the slow, continuous addition of saturated citric acid to give the product N-tert-butoxycarbonyl-L-phenylalanine (21.5 g, 81%); mp 85℃; [a]21D = t25:5 (c = 1, ethanol).

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

N-(tert-Butoxycarbonyl)-L-phenylalanine Preparation Products And Raw materials

Raw materials

L-Phenylalanine 1,4-Dioxane

Preparation Products

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N-(tert-Butoxycarbonyl)-L-phenylalanine Suppliers

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View Lastest Price from N-(tert-Butoxycarbonyl)-L-phenylalanine manufacturers

Shaanxi Xianhe Biotech Co., Ltd
Product
N-(tert-Butoxycarbonyl)-L-phenylalanine 13734-34-4
Price
US $0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
1000KG
Release date
2025-04-24
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-Phe-OH 13734-34-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
1000kgs
Release date
2021-09-23
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-Phe-OH 13734-34-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-21

13734-34-4, N-(tert-Butoxycarbonyl)-L-phenylalanineRelated Search:

L-Alanine BOC-Glycine Boc-D-Glutamine BOC-MET-ONP BOC-GLU(OME)-OH Boc-L-Pyroglutamic acid methyl ester Boc-L-glutamic acid γ-allyl ester BOC-TYR(ET)-OH BOC-PHE-OSU 4-Amino-N-(tert-butoxycarbonyl)-L-phenylalanine BOC-4-NITRO-L-PHENYLALANINE BOC-L-4-Chlorophe Boc-N-methyl-L-phenylalanine N-tert-Butoxycarbonyl-L-phenylalanine amide BOC-D-Phenylalanine N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE ACID HYDRAZIDE N-tert-Butoxycarbonyl-DL-phenylalanine BOC-4-IODO-L-PHENYLALANINE

  • n-[(1,1-dimethylethoxy)carbonyl]-l-phenylalanin
  • L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-
  • N-(tert-Butoxycarbonyl)-L-phenylalanine ,98.5%
  • Boc-L-phenylalanine ,98%
  • (2S)-2-(tert-Butoxycarbonylamino)-3-phenylpropionic acid
  • (S)-2-(tert-Butoxycarbonylamino)-3-phenylpropanoic acid
  • N-(tert-Butyloxycarbonyl)-L-phenylalanine
  • N-(tert-butoxycarbonyl)-L-phenylalaninal
  • Boc-L-phenylalanine ,98.5%
  • 2-BOC-AMINO-3-PHENYL-PROPIONIC ACID
  • Boc-L-phenylalanine,N-(tert-Butoxycarbonyl)-L-phenylalanine
  • L-PHENYLALANINE-N-T-BOC
  • (S)-N-(tert-Butoxycarbonyl)phenylalanine
  • tert-Butoxycarbonyl-L-phenylalanine
  • N-Boc-L-phenylalanine Boc-Phe-OH
  • (2S)-2-{[(tert-butoxy)carbonyl]aMino}-3-phenylpropanoic acid
  • Boc-Phe-OH >=99.0% (T)
  • N-(tert-Butoxycarbonyl)-L-phenylalanine SynonyMs N-[(1,1-DiMethylethoxy)carbonyl]-L-phenylalanine
  • Boc-L-phenylalanine≥ 99% (HPLC)
  • Tert-Butoxycarbonyl L-Phenylalanine (BOC-L Phenylalanine)
  • BOC-L-Phenylalanine, 99+%
  • BOC-L-Phenylalanine(Boc-Phe-OH)
  • N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE(BOC-L-PHE-OH)
  • 2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONIC ACID
  • N-Butoxycarbonyl-L-phenylalanine
  • N-T-BOC-L-PHENYLALANINE FREE ACID
  • N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE, 99+%
  • BOC-PHE-OH
  • BOC-PHENYLALANINE
  • BOC-PHE
  • BOC-L-PHE
  • BOC-L-PHENYLALANINE
  • BOC-L-PHENYLALANINE-OH
  • BOC-L-PHE-OH
  • Boc-Phe-OH (Boc-L-Phenylalanine)
  • N-ALPHA-T-BUTYLOXYCARBONYL-L-PHENYLALANINE
  • (2R)-3-phenyl-2-(tert-butoxycarbonylamino)propanoic acid
  • BOC Phenly Alanine
  • BOC-L-PHENYLALANINE extrapure
  • N-(tert-Butoxycarbonyl)-L-phenylalanine, Boc-L-phenylalanine
  • N-TERT-BUTYLOXYCARBONYL-DL-PHENYLALANINE
  • N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE
  • N-T-BOC-L-PHENYLALANINE
  • N-T-BUTOXYCARBONYL-L-PHENYLALANINE
  • N-[(1,1-Dimethylethoxy)carbonyl]-L-phenylalanine
  • N-BOC-L-PHENYLALANINE
  • N-ALPHA-TERT-BUTYLOXYCARBONYL-L-PHENYLALANINE
  • N-ALPHA-T-BUTOXYCARBONYL-L-PHENYLALANINE
  • N-ALPHA-T-BOC-L-PHENYLALANINE
  • T-BUTYLOXYCARBONYL-L-PHENYLALANINE
  • TBOC-L-PHENYLALANINE
  • (S)-2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONIC ACID
  • RARECHEM AL BE 0755
  • N-Boc-L-phenylalanine,99%e.e.
  • (Tert-Butoxy)Carbonyl Phe-OH
  • (2S-2-[(2-MethylpropaN-2-Yloxycarbonylamino]-3-Phenylpropanoic Acid
  • N-(tert-Butoxycarbonyl)-L-phenylalanine &gt
  • BOC-ph-OH