3-chloro-4-(pyridin-2-ylmethoxy)aniline
- Product Name
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline
- CAS No.
- 524955-09-7
- Chemical Name
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline
- Synonyms
- 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;AKOS B033273;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;UKRORGSYN-BB BBV-019513;Neratinib Intermediate1;AKOS B033273(524955-09-7)
- CBNumber
- CB4801557
- Molecular Formula
- C12H11ClN2O
- Formula Weight
- 234.68
- MOL File
- 524955-09-7.mol
3-chloro-4-(pyridin-2-ylmethoxy)aniline Property
- Melting point:
- 91.0 to 95.0 °C
- Boiling point:
- 402.5±35.0 °C(Predicted)
- Density
- 1.292±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 3.88±0.10(Predicted)
- color
- White to Light yellow to Light orange
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C3150
- Product name
- 3-Chloro-4-(2-pyridylmethoxy)aniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $152
- Updated
- 2024/03/01
- Product number
- C3150
- Product name
- 3-Chloro-4-(2-pyridylmethoxy)aniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $456
- Updated
- 2024/03/01
- Product number
- C429263
- Product name
- 3-Chloro-4-(2-pyridylmethoxy)aniline
- Packaging
- 5g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- C429263
- Product name
- 3-Chloro-4-(2-pyridylmethoxy)aniline
- Packaging
- 10g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- C429263
- Product name
- 3-Chloro-4-(2-pyridylmethoxy)aniline
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Usage,Production
Uses
3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.
Synthesis
3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL).
The mixture was stirred at 60° C. overnight.
Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate.
The organic phase was separated, washed with saturated brine and dried.
The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained.
1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
3-chloro-4-(pyridin-2-ylmethoxy)aniline Suppliers
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View Lastest Price from 3-chloro-4-(pyridin-2-ylmethoxy)aniline manufacturers
- Product
- 3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
- Price
- US $0.00-0.00/Kg/Bag
- Min. Order
- 100g
- Purity
- 98%min
- Supply Ability
- 100kg
- Release date
- 2021-12-01
- Product
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline 524955-09-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-22
- Product
- 3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30