ChemicalBook > CAS DataBase List > 3-chloro-4-(pyridin-2-ylmethoxy)aniline

3-chloro-4-(pyridin-2-ylmethoxy)aniline

Product Name
3-chloro-4-(pyridin-2-ylmethoxy)aniline
CAS No.
524955-09-7
Chemical Name
3-chloro-4-(pyridin-2-ylmethoxy)aniline
Synonyms
3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;AKOS B033273;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;UKRORGSYN-BB BBV-019513;Neratinib Intermediate1;AKOS B033273(524955-09-7)
CBNumber
CB4801557
Molecular Formula
C12H11ClN2O
Formula Weight
234.68
MOL File
524955-09-7.mol
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3-chloro-4-(pyridin-2-ylmethoxy)aniline Property

Melting point:
91.0 to 95.0 °C
Boiling point:
402.5±35.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
3.88±0.10(Predicted)
color 
White to Light yellow to Light orange
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3150
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$152
Updated
2024/03/01
TCI Chemical
Product number
C3150
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$456
Updated
2024/03/01
TRC
Product number
C429263
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging
5g
Price
$70
Updated
2021/12/16
TRC
Product number
C429263
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging
10g
Price
$110
Updated
2021/12/16
TRC
Product number
C429263
Product name
3-Chloro-4-(2-pyridylmethoxy)aniline
Packaging
1g
Price
$45
Updated
2021/12/16
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3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Usage,Production

Uses

3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.

Synthesis

3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL). The mixture was stirred at 60° C. overnight. Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried. The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained. 1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).

3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

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3-chloro-4-(pyridin-2-ylmethoxy)aniline Suppliers

Jinan XuanDe Chemical Co., Ltd.
Tel
0531-88803958; 18866891188
Fax
0531-82777287
Email
zhaojiangxia@shiningpharm.com
Country
China
ProdList
276
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TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.
Tel
022-60182192,1339732154 18722583064
Fax
86-22-60979672
Email
marketing@pharmacn.com
Country
China
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Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
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JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
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9513
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Shanghai Boc Chemical Co.,Ltd
Tel
021-34975603-808 18721111801
Fax
+86-21-34975602-805
Email
sales@bocpharma.com
Country
China
ProdList
997
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64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
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64
Shanghai Kuanghao Chemistry Technology Co., Ltd.
Tel
13130049594 13130049594
Fax
021-37285512
Email
83219210@qq.com
Country
China
ProdList
95
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57
SpringPharma Tech Co.,Ltd
Tel
+86-25-68710855, +86-25-68710897
Fax
025-68710856
Email
sales@springpharma.net
Country
China
ProdList
1261
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View Lastest Price from 3-chloro-4-(pyridin-2-ylmethoxy)aniline manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
Price
US $0.00-0.00/Kg/Bag
Min. Order
100g
Purity
98%min
Supply Ability
100kg
Release date
2021-12-01
Nanjing Fred Technology Co., Ltd
Product
3-chloro-4-(pyridin-2-ylmethoxy)aniline 524955-09-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-22
Henan Aochuang Chemical Co.,Ltd.
Product
3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

524955-09-7, 3-chloro-4-(pyridin-2-ylmethoxy)anilineRelated Search:


  • AKOS B033273
  • 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE
  • 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-PHENYLAMINE
  • ART-CHEM-BB B033273
  • UKRORGSYN-BB BBV-019513
  • 3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine
  • 3-Chloro-4-[(pyridin-2-yl)Methoxy]benzenaMine [3-Chloro-4-(pyridin-2-ylMethoxy)phenyl]aMine
  • BenzenaMine, 3-chloro-4-(2-pyridinylMethoxy)-
  • 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline
  • Neratinib Intermediate1
  • 3-Chloro-4-(pyridin-2-ylmethoxy)
  • 3-Chloro-4-(2-pyridylmethoxy)aniline
  • 3-Chloro-4-(pyridine-2-ylmethoxy)aniline
  • AKOS B033273(524955-09-7)
  • 4-((pyridin-2-yl)methoxy)-3-chlorobenzenamine
  • methoxy)aniL
  • oro-4-(2-pyridyL
  • AKOS B033273 ISO 9001:2015 REACH
  • Neratinib Impurity 41
  • 524955-09-7 AKOS B033273
  • 3-Chloro-4-(pyridin-2-ylmethoxy)aniline (Neratinib Impurity)
  • 3-chloro-4-(pyridin-2-ylmethoxy)aniline
  • 3-chloro-4-(2-pyridinylmethoxy) benzeneamine
  • 524955-09-7
  • 524955-09-7